Do Prolia injections affect the kidneys?

Thank you. I see nephrology next week and endocrinology next month. I will run this by both of them. Could you keep me posted on how this works out for you?

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I have been on Prolia for about 8 years. About a year ago I developed kidney disease picked up on routine visit and blood work done at the hematology/ oncology office I have been going to and where I received Prolia. My creatinine was 3, BUN was 50 and GFR 17. I was sent to a nephrologist and no one could tell me what caused the dramatic increase in my numbers. Prior my creatinine had been 1.4-1.6 labeled as insufficient kidney function minor now I am told I have stage 3-4 kidney disease. I have done a lot of research as I am someone who needs answers and yes kidney disease is not listed as a side effect of Prolia HOWEVER there are studies that show Prolia can cause a SIGNIFICANT increase in PTH levels ,,,, and high PTH over time can cause kidney disease !, PTH is not commonly tested nor was it at my hematologist, The kidney doctor does it as part of his standard panel and when it was over 900 thought that it was lab error but it came back high on the repeated test as well . My own research led me to Prolia as a reason for the PTH and in the 6 months it decreased to 190 I did not take one again until I have more information. If this has been happening every 6 mos for 8 years I have to wonder if this was the cause of my sudden decline in kidney function .............

If anyone has had any similar issue please respond,! It is not a link easily made took a lot of looking at different research and articles I do believe this is something that should be mentioned in the Prolia literature but is not !!!!

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Same here. After last Prolia shot within six months my GFR went from 59 to 43. I was taking Prolia for six years twice a year. Also ibuprofen had an effect. When I stopped ibuprofen for one month my kidney function went back to 58. But my pain management doctor told me Prolia interferes with kidney function. Something to do with phosphates. I’m going to stop Prolia. They say stop gradually but how does one do that when taking it every six months? I still have questions.

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Same here. After last Prolia shot within six months my GFR went from 59 to 43. I was taking Prolia for six years twice a year. Also ibuprofen had an effect. When I stopped ibuprofen for one month my kidney function went back to 58. But my pain management doctor told me Prolia interferes with kidney function. Something to do with phosphates. I’m going to stop Prolia. They say stop gradually but how does one do that when taking it every six months? I still have questions.

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