Hyperhomocysteinemia with MTHFR C677T mutations. Does anyone have this

Posted by ronniekep @ronniekep, Nov 8, 2018

Hi, I took a DNA test to see what medications I could not take and while finding out, I would out I carry this gene. Does anyone else have this? I know I am not alone! I have raised my folate and B12 and B6 but I delay the response to antidepressants.

@diannelk

I will start out with the fact that I am not a doctor or a pharmacist or a geneticist and am not offering advice. I am a person with almost identical methylation SNPs, each of which reduce the body‘s ability to utilize folic acid. Mine were shown to be in the yellow zone on testing, not red. The data I provide comes from a paper written by PureGenomics in Ontario Canada. My diagnosis eventually came through a most knowledgable ND, just 4 years ago. At the same time, I am all for doctors and have been a patient of Mayo for 60 years. I wonder if Mayo has NDs on staff who could guide you moving forward, I’m sure there are geneticists available to answer your questions? Wishing the best to you and your wife!

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Can you share the name of the ND that you saw and eventually helped you? Did you have highly elevated b6 related to the mthfr gene mutation? I’m a pharmacist by training & im suspect that my wife is actually low in p-5-p active form of bit b6 as synthetic form is not being converted over to usable form of p_5_p. Mainstream medicine is lost in this type of problem & trying to find knowledgeable & reliable ND that knows what we are dealing with. Thanks for sharing ND contact & possible that we could arrange a telemedicine call. Best regards. Allen

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Thank you Allen. Any chance you would feel comfortable sharing your email with me, or your wife’s email perhaps, so we can discuss offsite? I feel this is getting more personal than some others would require, if you wouldn’t mind? Thank you, Dianne

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@diannelk

Thank you Allen. Any chance you would feel comfortable sharing your email with me, or your wife’s email perhaps, so we can discuss offsite? I feel this is getting more personal than some others would require, if you wouldn’t mind? Thank you, Dianne

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@diannelk and @monk1015, should you wish to exchange personal contact information, I recommend that you use the private message function. This is a more secure way to share email addresses.

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@bet

Thank you so much for your reply. Which vaccine did you receive?

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Hmm, not sure why my previous answer didn’t post? Both were Pfizer, in Canada I waited 10 weeks for second dose

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@msfxit

He put us both on Folinic Acid 500 per day. We both have migraines with aura anemia lethargic and I have narcolepsy also. We took our first dose yesterday I was fine but I ended up taking my daughter to hospital she had an allergic reaction. Her throat closed up and she got an itchy rash

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Your daughters reaction, that is exactly what happens to me when I tried to take B12, has she been patch tested for Metals?

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