Hyperhomocysteinemia with MTHFR C677T mutations. Does anyone have this

Posted by ronniekep @ronniekep, Nov 8, 2018

Hi, I took a DNA test to see what medications I could not take and while finding out, I would out I carry this gene. Does anyone else have this? I know I am not alone! I have raised my folate and B12 and B6 but I delay the response to antidepressants.

@gldnrtrvrlvr

@erikas I found a pharmacist at a compounding pharmacy who was my first source of information and was a gem on knowledge. Since then, I've done a lot of research on my own via NIC, John Hopkins, and other well-known institutions, plus some other alternative options. Thanks for your response.

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Hello @gldnrtrvrlvr

As it has been a while since you last posted I was wondering how you are doing. Will you post an update at your convenience?

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Has anyone with the double mthfr variant received the COVID 19 vaccine?

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My wife has experienced neuropathic pain in her legs and feet for years. Our primary care md at UAB’s Kirklin Clinic in Birmingham tested her vitamin B6 level and it’s extremely high at 174. She takes no supplements and as a pharmacist I started researching this and found that the C677T & A12980 mutations of the MTHFR gene could be the source of this elevated B6 as these mutations of these genes prevent the conversion of the synthetic b6 to p-5-p form of b6 that is used by our cells. In fact I find literature indicating that she could literally be low in the needed b6form used by her cells and could need supplements of p-5-p form of B6. In summary these mutations and B6 issues could be source of her peripheral neurophy pain in her lowe legs and feet. We cannot find Any md’s at UAB that know how to treat this condition and I’m reaching out to see if anyone else has dealt with this issue and if help is available at Mayo ofr John’s Hopkins to help us deal with this problem with clinical treatment.

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@monk1015

My wife has experienced neuropathic pain in her legs and feet for years. Our primary care md at UAB’s Kirklin Clinic in Birmingham tested her vitamin B6 level and it’s extremely high at 174. She takes no supplements and as a pharmacist I started researching this and found that the C677T & A12980 mutations of the MTHFR gene could be the source of this elevated B6 as these mutations of these genes prevent the conversion of the synthetic b6 to p-5-p form of b6 that is used by our cells. In fact I find literature indicating that she could literally be low in the needed b6form used by her cells and could need supplements of p-5-p form of B6. In summary these mutations and B6 issues could be source of her peripheral neurophy pain in her lowe legs and feet. We cannot find Any md’s at UAB that know how to treat this condition and I’m reaching out to see if anyone else has dealt with this issue and if help is available at Mayo ofr John’s Hopkins to help us deal with this problem with clinical treatment.

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Welcome, @monk1015. I encourage you to join the well informed members of the Neuropathy group here: https://connect.mayoclinic.org/group/neuropathy/

You'll get support, answers and guidance there.

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@bet

Has anyone with the double mthfr variant received the COVID 19 vaccine?

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@bet– Good morning and welcome to Mayo Clinic Connect. Have you spoken with your doctor about this? Have you had other vaccines?

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@merpreb

@bet– Good morning and welcome to Mayo Clinic Connect. Have you spoken with your doctor about this? Have you had other vaccines?

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The doctor is attempting to find more information and is reluctant to recommend the vaccine without more information. It appears there is limited information. The teaching university where records were sent has yet to respond after several phone calls. It appears there is limited and confusing research on this gene.
Other types of vaccinations have not caused major problems. Sensitivity to metals, medications, and foods have been issues.

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@bet

The doctor is attempting to find more information and is reluctant to recommend the vaccine without more information. It appears there is limited information. The teaching university where records were sent has yet to respond after several phone calls. It appears there is limited and confusing research on this gene.
Other types of vaccinations have not caused major problems. Sensitivity to metals, medications, and foods have been issues.

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I'm very glad that he is being cautious. Keep being very protective of your own safety and health

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@merpreb

I'm very glad that he is being cautious. Keep being very protective of your own safety and health

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Would Mayo have any helpful information on MTHFR variant and the vaccine?It is extremely frustrating not being able to find information.

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@bet

Would Mayo have any helpful information on MTHFR variant and the vaccine?It is extremely frustrating not being able to find information.

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Bet- Pretty frustrating, right. I have forwarded your question to the moderators hoping that someone has answers for you. I'm truly sorry that I can't be of any help.
Merry

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@bet

Has anyone with the double mthfr variant received the COVID 19 vaccine?

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Yes, I have. For me personally there were no issues with it at all, except for the fact that I had a bit of a tender arm the first couple of days with the first dose. Didn’t notice anything with the second dose. However that’s just my own experience and I am not a doctor, pharmacist or geneticist, and can’t give advice

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@monk1015

My wife has experienced neuropathic pain in her legs and feet for years. Our primary care md at UAB’s Kirklin Clinic in Birmingham tested her vitamin B6 level and it’s extremely high at 174. She takes no supplements and as a pharmacist I started researching this and found that the C677T & A12980 mutations of the MTHFR gene could be the source of this elevated B6 as these mutations of these genes prevent the conversion of the synthetic b6 to p-5-p form of b6 that is used by our cells. In fact I find literature indicating that she could literally be low in the needed b6form used by her cells and could need supplements of p-5-p form of B6. In summary these mutations and B6 issues could be source of her peripheral neurophy pain in her lowe legs and feet. We cannot find Any md’s at UAB that know how to treat this condition and I’m reaching out to see if anyone else has dealt with this issue and if help is available at Mayo ofr John’s Hopkins to help us deal with this problem with clinical treatment.

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I will start out with the fact that I am not a doctor or a pharmacist or a geneticist and am not offering advice. I am a person with almost identical methylation SNPs, each of which reduce the body‘s ability to utilize folic acid. Mine were shown to be in the yellow zone on testing, not red. The data I provide comes from a paper written by PureGenomics in Ontario Canada. My diagnosis eventually came through a most knowledgable ND, just 4 years ago. At the same time, I am all for doctors and have been a patient of Mayo for 60 years. I wonder if Mayo has NDs on staff who could guide you moving forward, I’m sure there are geneticists available to answer your questions? Wishing the best to you and your wife!

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@diannelk

Yes, I have. For me personally there were no issues with it at all, except for the fact that I had a bit of a tender arm the first couple of days with the first dose. Didn’t notice anything with the second dose. However that’s just my own experience and I am not a doctor, pharmacist or geneticist, and can’t give advice

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Thank you so much for your reply. Which vaccine did you receive?

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