1. < Depression & Anxiety

Hyperhomocysteinemia with MTHFR C677T mutations. Does anyone have this

Posted by ronniekep @ronniekep, Nov 8, 2018

Hi, I took a DNA test to see what medications I could not take and while finding out, I would out I carry this gene. Does anyone else have this? I know I am not alone! I have raised my folate and B12 and B6 but I delay the response to antidepressants.

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Merry, Alumni Mentor | @merpreb | Jul 9, 2021
In reply to @bet "The doctor is attempting to find more information and is reluctant to recommend the vaccine without..." + (show)
@bet

The doctor is attempting to find more information and is reluctant to recommend the vaccine without more information. It appears there is limited information. The teaching university where records were sent has yet to respond after several phone calls. It appears there is limited and confusing research on this gene.
Other types of vaccinations have not caused major problems. Sensitivity to metals, medications, and foods have been issues.

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I'm very glad that he is being cautious. Keep being very protective of your own safety and health

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1 reply
bet | @bet | Jul 9, 2021
In reply to @merpreb "I'm very glad that he is being cautious. Keep being very protective of your own safety..." + (show)
@merpreb

I'm very glad that he is being cautious. Keep being very protective of your own safety and health

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Would Mayo have any helpful information on MTHFR variant and the vaccine?It is extremely frustrating not being able to find information.

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diannelk | @diannelk | Jul 12, 2021
In reply to @bet "Has anyone with the double mthfr variant received the COVID 19 vaccine?" + (show)
@bet

Has anyone with the double mthfr variant received the COVID 19 vaccine?

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Yes, I have. For me personally there were no issues with it at all, except for the fact that I had a bit of a tender arm the first couple of days with the first dose. Didn’t notice anything with the second dose. However that’s just my own experience and I am not a doctor, pharmacist or geneticist, and can’t give advice

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1 reply
diannelk | @diannelk | Jul 12, 2021
In reply to @monk1015 "My wife has experienced neuropathic pain in her legs and feet for years. Our primary care..." + (show)
@monk1015

My wife has experienced neuropathic pain in her legs and feet for years. Our primary care md at UAB’s Kirklin Clinic in Birmingham tested her vitamin B6 level and it’s extremely high at 174. She takes no supplements and as a pharmacist I started researching this and found that the C677T & A12980 mutations of the MTHFR gene could be the source of this elevated B6 as these mutations of these genes prevent the conversion of the synthetic b6 to p-5-p form of b6 that is used by our cells. In fact I find literature indicating that she could literally be low in the needed b6form used by her cells and could need supplements of p-5-p form of B6. In summary these mutations and B6 issues could be source of her peripheral neurophy pain in her lowe legs and feet. We cannot find Any md’s at UAB that know how to treat this condition and I’m reaching out to see if anyone else has dealt with this issue and if help is available at Mayo ofr John’s Hopkins to help us deal with this problem with clinical treatment.

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I will start out with the fact that I am not a doctor or a pharmacist or a geneticist and am not offering advice. I am a person with almost identical methylation SNPs, each of which reduce the body‘s ability to utilize folic acid. Mine were shown to be in the yellow zone on testing, not red. The data I provide comes from a paper written by PureGenomics in Ontario Canada. My diagnosis eventually came through a most knowledgable ND, just 4 years ago. At the same time, I am all for doctors and have been a patient of Mayo for 60 years. I wonder if Mayo has NDs on staff who could guide you moving forward, I’m sure there are geneticists available to answer your questions? Wishing the best to you and your wife!

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1 reply
bet | @bet | Jul 12, 2021
In reply to @diannelk "Yes, I have. For me personally there were no issues with it at all, except for..." + (show)
@diannelk

Yes, I have. For me personally there were no issues with it at all, except for the fact that I had a bit of a tender arm the first couple of days with the first dose. Didn’t notice anything with the second dose. However that’s just my own experience and I am not a doctor, pharmacist or geneticist, and can’t give advice

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Thank you so much for your reply. Which vaccine did you receive?

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1 reply
diannelk | @diannelk | Jul 12, 2021

You are very welcome! Both were Pfizer, they were 10 weeks apart. I am in Canada. Very best wishes to you

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monk1015 | @monk1015 | Jul 12, 2021
In reply to @diannelk "I will start out with the fact that I am not a doctor or a pharmacist..." + (show)
@diannelk

I will start out with the fact that I am not a doctor or a pharmacist or a geneticist and am not offering advice. I am a person with almost identical methylation SNPs, each of which reduce the body‘s ability to utilize folic acid. Mine were shown to be in the yellow zone on testing, not red. The data I provide comes from a paper written by PureGenomics in Ontario Canada. My diagnosis eventually came through a most knowledgable ND, just 4 years ago. At the same time, I am all for doctors and have been a patient of Mayo for 60 years. I wonder if Mayo has NDs on staff who could guide you moving forward, I’m sure there are geneticists available to answer your questions? Wishing the best to you and your wife!

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Can you share the name of the ND that you saw and eventually helped you? Did you have highly elevated b6 related to the mthfr gene mutation? I’m a pharmacist by training & im suspect that my wife is actually low in p-5-p active form of bit b6 as synthetic form is not being converted over to usable form of p_5_p. Mainstream medicine is lost in this type of problem & trying to find knowledgeable & reliable ND that knows what we are dealing with. Thanks for sharing ND contact & possible that we could arrange a telemedicine call. Best regards. Allen

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diannelk | @diannelk | Jul 12, 2021

Thank you Allen. Any chance you would feel comfortable sharing your email with me, or your wife’s email perhaps, so we can discuss offsite? I feel this is getting more personal than some others would require, if you wouldn’t mind? Thank you, Dianne

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1 reply
Moderator
Colleen Young, Connect Director | @colleenyoung | Jul 12, 2021
In reply to @diannelk "Thank you Allen. Any chance you would feel comfortable sharing your email with me, or your..." + (show)
@diannelk

Thank you Allen. Any chance you would feel comfortable sharing your email with me, or your wife’s email perhaps, so we can discuss offsite? I feel this is getting more personal than some others would require, if you wouldn’t mind? Thank you, Dianne

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@diannelk and @monk1015, should you wish to exchange personal contact information, I recommend that you use the private message function. This is a more secure way to share email addresses.

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diannelk | @diannelk | Jul 19, 2021
In reply to @bet "Thank you so much for your reply. Which vaccine did you receive?" + (show)
@bet

Thank you so much for your reply. Which vaccine did you receive?

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Hmm, not sure why my previous answer didn’t post? Both were Pfizer, in Canada I waited 10 weeks for second dose

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