Getting off of Seroquel

Posted by anniegk @anniegk, Jun 8, 2018

I have been on 300 mgs. Seroquel ER for over a year for augmenting my antidepressant which is 45 mgs. Of Mirtazapine. I decided to try and get off of the Seroquel. I was on 300mgs ER (extended release). I titrated down to 250 mg ER for 2 months without too many problems.than i titrated down to 200mgs ER just 5 days ago. My plan is to try to titrate off using ER tablets. My thinking is that perhaps the drug will remove its self from my system more gradually. I have had some nausea and a couple of episodes of diarrhea. I also have a very irregular heart beat and was started on 60 mgs of Propranolol ER (extended release) 4 weeks ago. It seems to be helping my heartbeat. I have wondered if the nausea and light headness is from the Propranolol, a Beta Blocker, or the dose reduction of the Seroquel. I also wonder if the way iam titrating the Seroquel is safe. My doctor says it will only take a couple of weeks…I think that is too fast of a taper after being on a drug for over a year. What do you think?

@azgilger4

Prazosin? What is that?

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Hi, @azgilger4 – welcome to Mayo Clinic Connect.

Here is some Mayo Clinic information on prazosin that may be useful https://www.mayoclinic.org/drugs-supplements/prazosin-oral-route/description/drg-20065617

Have you also taken quetiapine (Seroquel)? Did you or are you in the process of tapering off of it?

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@hopeful123

I have gotten off 600mg Seroquel but not the XR. It was being used to help me sleep probably anti anxiety as well. It was tough and took about 6 months but I have been off it about 6 months now. Tons of nausea when I went off it but my doctor explained it absolutely is normal because it does work on some sort of anti nausea brain receptors. I got down to 25mg then stopped. I’m still completing a benzodiazepine taper but I am glad I got off the Seroquel as it fogged my thinking.

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Hi Hopeful123
I'm very pleased to have read this message you posted. I can relate. I am currently on 600 mg of Seriqual and with my doctor we are going to decrese it. I am also staying on abilify.
How are things with you now?
How slow should I taper? (I've been on quitipine for approx 15 years).
What should I know and expect?
-it would be great to hear from you or anyone else related. Thank you.

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@lifeshope

Hi Hopeful123
I'm very pleased to have read this message you posted. I can relate. I am currently on 600 mg of Seriqual and with my doctor we are going to decrese it. I am also staying on abilify.
How are things with you now?
How slow should I taper? (I've been on quitipine for approx 15 years).
What should I know and expect?
-it would be great to hear from you or anyone else related. Thank you.

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@lifeshope
It’s hard to say since people are different, some people can easily get off medication while others have a lot of problems. Chances are your doctor will have you cut back to quickly and you may get side effects, if you do you’re obviously reducing it to fast a pace. You’re either reducing buy two large a percentage or not staying on your titrated dose for a long enough period of time. It’s usually thought you should stay on each taper dose for 3 to 6 weeks before reducing again. Another concern is the fact that you’ve been on this medication for a long period of time, because of that you’ll probably want to taper even slower. One thing to be cautious about is to not reduce your dose by the same milligram each month or whatever period of time you choose. For instance don’t reduce 50 or 100 mg every month because the percentage the percentage you’re decreasing your medication actually goes up. It’s much better to reduce by a certain percentage. Consistency will help you to not have side effects. In some medications they use the 5 to 10% rule, although few doctors use it, I believe you’ll find virtually everybody on this forum who has tried to get off of different drugs and use the doctors titration advice is complaining of side effects. Most people who get off the drug Klonopin a seizure medication have a lot of side effects. I got off of it without any side effects but I did it extremely slowly. So I guess it really depends on how quickly you want off your medicine and whether or not you’re willing to deal with the side effects. Stopping the medication quickly will cause will cause more withdrawal effects. Just remember you don’t have to suffer these horrendous side effects so many people complain about. Speed is your enemy. You’ve already taken this drug for 15 years that’s a long time, what’s another year or two. What’s important is to decrease your dose every month without having side effects. Seroquel has an approximate half-life of only six hours so I would take it slow. I hope you let us know the rate that your doctor want you to decrease. Remember that if you take a larger cut in the beginning, although I wouldn’t recommend it, you might not notice the side effects as much as you will when you get down to a lower dose.
I wish you the very best of luck,
Jake

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How did it go? Are you ok?

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@ginak523

I just stopped it cold turkey and feel much better ! Thank you for responding .

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How much were you taking? And for how long

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@lisalucier

Hi, @azgilger4 – welcome to Mayo Clinic Connect.

Here is some Mayo Clinic information on prazosin that may be useful https://www.mayoclinic.org/drugs-supplements/prazosin-oral-route/description/drg-20065617

Have you also taken quetiapine (Seroquel)? Did you or are you in the process of tapering off of it?

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Hello I am on 400mg of seroquel and 1/2 mg of klonopin. No I haven't started tapering yet. Looking to learn how though. 3 months for them both. I can't stand how the seroquel has ruined my life. I am afraid I will never sleep properly now on my own- which I desperately want again.

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@jh1

I’m beginning to sleep better after two weeks off 740 mgs and 16 years on Seroquel. I think that the Geodon is actually not helping me sleep that much so it looks like I might be through it. I think it’s possible with persistence and belief. Let’s keep each other updated

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Hi, I am interested on how your sleep is going. I am on 400mg of seroquel. Only 3months. Would love to get off this horrible med.

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@lisalucier

Hi, @anniegk — I apologize for not responding earlier, but somehow I missed getting a notification about your post! I'm wondering about how your taper off of Quetiapine (Seroquel) has been going.

I'd like to invite @derryman @IndianaScott @loveallmyboys @whereveryougothereyouare @tib85 @giacamosgirl58 @majic @hwilson7 @resolve @ronlin1948 @ginak523 and @cathy615 into this discussion to share their thoughts and experiences with Quetiapine (Seroquel)and tapering, if that applies. @gailb and @gman007 may also have some thoughts about the journey going off this medication and the side effects you've experienced.

You mentioned taking Quetiapine (Seroquel) in addition to Remeron (Mirtazapine) and then deciding to try and get off the Seroquel. Curious about what made you want to discontinue the medication? Were you having unpleasant side effects?

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Hi there, I really would love some insight on tapering of 400mg 450mg of seroquel

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@yangedd

Hi @anniegk

I reduced from 400mg Seroquel (Slow release one) not so long ago. I was on 300mg in the morning and 100mg at night. My actual plan was to be off all medication by Christmas, but unfortunately there have been a few bends on the road. My GP and Psychiatrist weren't that happy with the idea, but I convinced them that I was able to do it. To make a long story short, I went from the 300mg in the morning right down to 100mg and 100mg at night. Yes, there are withdrawal symptoms as I was apprehensive, had a little agitation and some sweating during the day. I'm also on Mirtazapine (30mg at night) and wanted that reduced too but to no avail. They simply wouldn't allow me to stop it because of my suicidal ideation in the past and my long history of severe depression.

I'm so glad you mentioned Propranolol because I am on 40mg morning and night. The only thing I can say is that it can cause a very dry mouth, but I'm willing to put up with that because my palpatations, sweating and shaking in stressful situations ease off after I take it.

As for your Doctor, he can tell you this and that, but it's you going through the tapering so you and your body will know best. I really hope you manage to taper off without all the unpleasant symptoms that some people experience. As a person who's been on Seroquel for seven years I do know a little about it and everyone reacts differently to reducing medication doses,

Ed

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How are you!!How is the tapering going? How is your sleep?- christina

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@highserotonin30

I'm seeing him later on this month. I think I might need to get off the lexapro as well because when we first discussed the weight gain he took me off the seroquel and I barely lost any weight. I maintained almost all of the weight I have gained by being on the Lexapro by itself. So it's time for a change. This lexapro experiment has been going on for a year now. It's certainly helped with the depression but I'm still largely depressed. The same could be said about the seroquel.

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Go online and read " mad in america" There is some info on seroquel and other meds how dangerous they really are. And really don't help people. A lot of them actually cause the symptoms we get prescribed for. Especially in withdrawal.

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@hopeful123

I have gotten off 600mg Seroquel but not the XR. It was being used to help me sleep probably anti anxiety as well. It was tough and took about 6 months but I have been off it about 6 months now. Tons of nausea when I went off it but my doctor explained it absolutely is normal because it does work on some sort of anti nausea brain receptors. I got down to 25mg then stopped. I’m still completing a benzodiazepine taper but I am glad I got off the Seroquel as it fogged my thinking.

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How did it affect your sleep. Did you have to take anything else?

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@jakedduck1

@mxyzptlk
Good evening,
I’m not a scaremonger and I’m sorry you believe I am.

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Your not a scaremoger. Seroquel is dangerous period! There are so many articles and people's testimonials to prove so. Go online and read "mad in America" there are several articles on seroquel there.Ihave been on it for three months and its making a mess of my life. I hate it.

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