Experience trying over the counter lithium oronate 5mg daily?

Sorry...it's orotate!

Just an FYI that the corrcct name of the lithium being considered by some is lithium orotate. It's my understanding there are various forms of lithium. Also, 5 mg is the recommended starting dosage. Have you checked with her doctor to see what dosage he recommends?

Mea culpa for my misspelling of lithium oronate...and me with a degree in chemistry! Many of the more common lithium compounds, some of which have been used to treat bipolar and other mental conditions, can be toxic and must be monitored. I found a number of studies over the past 50 years where Li orotate was evaluated for its effects for various mental conditions including alz. 5 or 10 mg is far below toxic levels. There are a number of other medications that should be avoided. Carol takes none of those. The thread that runs through much of what I've found is that it may reverse alz! Everything being done for her is meant to slow it down! The words of the neurologist. There isn't time to find another chemical that does. Lithium orotate may be that one. And no, I've not talked to her neurologist. She stays in her lane with diagnosis and treatment.

My understanding is that there may be a relationship between low lithium levels in the brain and Alzheimer’s dementia, thus supplementation makes theoretical sense. Human studies, as I’m sure you r aware, are lacking. If u choose to take, keep in mind symptom awareness: Users should watch for signs of toxicity—tremor, confusion (difficult to assess in a person with Alzheimer’s), arrhythmia (abnormal heart rhythm), excessive thirst/urination—and discontinue use at any concerning symptom, followed by medical consultation. Keep your doctor in the loop, there may be drug interactions. Kidney and liver function should be monitored periodically. Lithium (any form) has a low therapeutic window (there is not much room between a beneficial dose and a potentially toxic dose), especially as one ages. There are many case reports of people with the symptoms listed above m even at the low dose of 5 mg/day. No reports of death that I found.

My husband, age 79, was diagnosed with Alzheimers two years ago after having an MRI as well as a lumbar puncture that revealed amyloid matter in his spinal fluid. He has been taking the same medications that your significant other is taking. He began Leqembi treatment shortly thereafter but stopped after six sessions because he felt the risk of brain bleeds wasn't worth the slight slowing of progression of the disease. This past June, he also had a blood test that confirmed he had one copy of the APOE4 gene variant, which does raise the risk for Alzheimers somewhat. However, a subsequent PET amyloid scan didn't show amyloid matter and didn't confirm the Alzheimers diagnosis! So when we met with his neurologist two weeks ago, he changed his diagnosis to "mixed dementia of frontaltemporal dimension with some Alzheimers characteristics." (As my son, who is in the medical field, said, these diagnoses from doctors about dementia tend to be rather "squishy.") Anyway, it was at that meeting that I brought up the possibility of my husband starting on the 5 mg of lithium orotate, based on an article my son had forwarded to me and subsequent comments on the Mayo website. The neurologist agreed he should go ahead and try it. Let's hope that the dementia progression in both my husband and in your loved one is reversed. One can only hope!

A recent article in the scientific journal Nature reports on the authors' success with slowing, and in some instances reversing, Alzheimer's in mice by administering small doses of lithium orotate. I'm not aware of any studies in humans (could be wrong) but this is unlikely to be fast-tracked since there's no real profit incentive for pharma (it's already available OTC). Is anyone else giving it to their loved one? Is anyone aware of research in humans? I've started my husband (diagnosed in 2017) 5 mg a day on the advice of his internist son. After 2 weeks, no side effects or changes.

There is a conversation on this site, under Aging Well, discussing the use of Lithium Oranate by individuals themselves.

My significant other, 82 yo female was diagnosed with Alz last Nov. She's been on memantine since then and donepezil since May. She has the Apoe4 gene which indicates the highest probability of Alz. We just received results of her amyloid PETscan. Her score was 146 which is exceedingly high. Her short term memory is very poor but aside from that she's pretty normal. Yesterday her neurologist said because of that result she should start Leqembi infusions. The local clinic that does them is booked until next March. It's an epidemic! We're concerned about the limited benefit and side effects of Leqembi, particularly brain bleeds, so we will probably decline the infusions.

I decided to start her on 10 mg lithium orotate capsules on Aug 23. We don't have time to wait for Big Pharma to invent the next wonder drug that actually treats Alz. There is no evidence that Leqembi infusions improve memory by removing amyloid deposits.

Recent lab studies with lithium orotate at Harvard look promising and data from areas where lithium content in water is high have lower levels of Alz. Li compounds at very high levels have been used to treat bipolar disorders in the past. The compound/supplement lithium orotate is available otc at levels much lower than the near-toxic levels of lithium carbonate used to treat bipolar. There is no way to determine if it is going to help but we have no other choice.

@longboat1
Our situation is very similar. My husband (88) is on memantine and donepezil, is pretty normal except for memory loss, and has one copy of the Apoe4 gene. He was in a trial of what ended up being named Leqembi, but he was dismissed from the trial after developing a number of small brain bleeds. The trial experienced at least one fatality attributed to brain bleeds. So you probably chose wisely. If lithium orotate actually helps, it will be a miracle!

One concern I didn't mention that favors not doing Leqembi is that when Carol had her initial mri last year it revealed a "mini-stroke" of unknown origin. She had no head injuries in the past and no stroke that left disabilities. With this history we'll discuss the wisdom of doing Leqembi infusions with her neurologist on Nov 24