Elevated Lp(a) levels - does Repatha help?

Posted by klaudiaarnold @klaudiaarnold, Jul 16, 2025

Hi everyone,
After reading up on it myself, I found out there are hardly any medications available to lower highly elevated Lp(a)= levels. However, I came across Repatha and read that it might also help reduce Lp(a) levels. Is there any chance in significantly lowering an elevated Lp(a) level (above 50mg/dl) with Repatha?

• Has anyone had personal experience with Repatha to lower Lp(a)?
• And does anyone know a doctor who prescribes Repatha for lowering Lp(a)?

Thanks in advance for sharing your knowledge or experiences!

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ginabratt | @ginabratt | 5 days ago

I have been on Repatha for several years, and it has reduced my numbers significantly. However, my triglycerides are still a little elevated. I would recommend Repatha over any other type of statin. I do not have a side effects from Repatha.

mariereine | @mariereine | 2 days ago

I have extremely elevated Lp(a) at 589nmol/L. With Repatha onboard, it went down to 369nmol/L-not normal, but better than being in the 99th percentile. of course, I am also on a statin and ezetimibe! No side effects from repatha-some myalgia with statin if I have a glass or two of wine, substantiated by above normal CK

paxmundi | @paxmundi | 1 day ago

In reply to @mariereine "I have extremely elevated Lp(a) at 589nmol/L. With Repatha onboard, it went down to 369nmol/L-not normal,..." + (show)

@mariereine Glad to hear it went down significantly, and didn’t give you side effects. Praying for the appproval of the meds in third phase trials that can lower lp(a) so much more. Hopefully we will have something by 2027!

paxmundi | @paxmundi | 1 day ago

In reply to @ginabratt "I have been on Repatha for several years, and it has reduced my numbers significantly. However,..." + (show)

@ginabratt Happy that you have no side effects. My value is 379.7 nmol/L and I had a low moderate stroke in January that luckily did not leave me with permanent motor impairment. They put me on the highest dose of Atorvastatin-80 mg. Now they want to put me on Repatha. Praying for those new drugs as I am also facing Bronchiectasis and NTM disease that require heavy-duty antibiotics for a very long period. Trying to keep my head up!

mariereine | @mariereine | 1 day ago

In reply to @paxmundi "@mariereine Glad to hear it went down significantly, and didn’t give you side effects. Praying for..." + (show)

@paxmundi
I think we are all waiting but it may be more in 2028-Pelacarsen will likely be the first one to go to market if approved by the FDA

paxmundi | @paxmundi | 1 day ago

In reply to @mariereine "@paxmundi I think we are all waiting but it may be more in 2028-Pelacarsen will likely..." + (show)

@mariereine I don't know if I will make it, but glad to know it's on its way for whoever needs it!

mariereine | @mariereine | 18 hours ago

In reply to @paxmundi "@mariereine I don't know if I will make it, but glad to know it's on its..." + (show)

@paxmundi I hope you do- mitigating all the other risk factors (Mediterranean diet, regular and daily exercise, statin, Zedia, and Repatha) will give you all the chances. Although elevated Lp(a) is not a welcome gift, I have read of people with less than half my level who have had a major cardiac event so there is more to this. Now measuring Apo B has been recently added. There is much that is not known and I include the role of genetics in there.

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