http://mayoresearch.mayo.edu/center-for-individualized-medicine/pharmacogenomics.asp

@dawn_giacabazi

http://mayoresearch.mayo.edu/center-for-individualized-medicine/pharmacogenomics.asp

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Thanks for the reminder, @dawn_giacabazi. I want to finish preparing a request to my cardiologist, nephrologist, and urologist for approval of some pharmacogenomics (PGx) tests to see whether any of them — or my HMO — is prepared to add them to their protocols for a range of diseases. I’ll submit the first such request in about 2 weeks.

Martin

@predictable

I owe everybody on this thread — especially @hopeful33250, @dawn_giacabazi, and @cynaburst — an update on my Diastolic Dysfunction after visiting with my cardiologist a few days ago. He told me A-fib is the very definition of DD, which is now a condition I probably can’t avoid, and after 2 years of it, I have learned to manage it. Since I have no tangible symptoms (other than a tendency to bleed from wounds, thanks to Coumadin therapy) he saw no reason for surgery and believes no medication would “cure” me. So management is the challenge, and he flatly stated that I need not fear trying a beta blocker in that effort. So my nephrologist prescribed carvedilol to bring my blood pressure down, starting with a minimal dose, possibly raising it over the next six weeks in hope of reaching a maximum positive (balanced) result.

Does this make sense to you? Do you have any suggestions for me based on your experience?

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Teresa, I pursued the DD and A-fib link after seeing some research from Mayo suggesting that beta blockers could produce adverse effects in some more serious DD cases. It turns out that the threat of this is rare — not for those of us who have DD as a result of A-fib, according to my cardiologist, but in cases where there is moderate to serious DD but no A-fib. So he gave the green light for me to take Carvedilol.

Martin

You are welcome. Remember these particular test is not for diseases. This is to help determine the exact medications to treat you at the right drug, at the right dose & the right time to prevent over dose and drug interactions. To also help prevent diseases like liver & kidndy failure from taking wrong medications. 🙂

@dawn_giacabazi

You are welcome. Remember these particular test is not for diseases. This is to help determine the exact medications to treat you at the right drug, at the right dose & the right time to prevent over dose and drug interactions. To also help prevent diseases like liver & kidndy failure from taking wrong medications. 🙂

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Yes, I should have said “for a range of therapies” rather than diseases, right?

I am sorry. I didn’t mean to correct you just want to make sure you knew it was more specific than testing diseases. That would be a whole different testing and a whole different set of guidelines and coverage by insurance.

No sweat! You’re right! Bad use of the word “diseases” by me.

Not good about your arrhythmia. But it is what it is. Fortunately, one of my early cardiologists suggested that beta blockers might not be good for my issues. Therefore, I have resisted them for years, along with CCBs and ACEs. Now the research seems to have caught up with this, according to the crews at Mayo-MI. You might catch some of their videos on cardiac, amyloidosis, etc. They are very, very good. Morie Gertz and Martha Grogan deal with this stuff often in videos and writings.