Delayed pain after bone marrow biopsy??

Posted by dazlin @dazlin, Jul 4, 2019

I had a bone marrow biopsy in back hip on June 14th. By the 2nd week I felt almost completely better. Then for some unexplainable reason on the 17th day after, I had very uncomfortable pain around the area of biopsy and up towards my back left side waist. It seems to let up, and actually feels better walking, but sitting and during night I can’t find a comfortable position. Cant sleep.
I’m trying advil, or tylenol, and biofreeze. Tomorrow will be 3 weeks since biopsy.
No infection, no fever…could it be nerve pain? I saw my oncologist for follow up on the 27th, and I felt fine, so I never complained. I wonder if its something I did that’s making the area hurt? I did give my Lab dog a bath the day I noticed the pain, and lifted him in the tub, but I was already feeling healed.
Anyone experience delayed onset of pain after a bone marrow biopsy? What to do…I dont want anymore tests…hopefully itll pass??

Interested in more discussions like this? Go to the Blood Cancers & Disorders group.

@snacker1206

I have not contacted the dr who did the BMB, because so many months have gone by and I kept thinking the next thing I try will take care of it, but nothing has. I am afraid he will ask why I waited 5 months. I have been using ice packs and tried gabapentin but it gave me migraines so I stopped. I have been taking muscle relaxers at bedtime with no relief. Thank you for responding so quickly. I am feeling pretty hopeless. You think I should reach out to the radiologist who performed it even tho so many months have gone by? I feel it would be a lost cause as all he would prob do is deny it is related.

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@snacker1206 Don't be intimidated by your dr or the radiologist. Explain what you have done to relieve the pain. If your area is anything like mine, it is difficult to get through to drs, and get help. Your team should be kept informed of your situation.

Please don't feel hopeless! Go back to the dr who ordered it, first. These biopsies are not done on a whim, so all this may be tied in with what they were looking for.
Ginger

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Hi @snacker1206 Welcome to Mayo Clinic Connect! In this community based forum, we’re not medical professionals so we can’t diagnose health problems or prescribe treatments. We’re members just like you who share personal experiences and insights to help find answers, give suggestions and offer encouragement.

What an awful experience! So basically you had the biopsy and were fine for a couple of weeks and then started having the nerve pain? Does the nerve pain radiate down your legs?
I’m so sorry you’re having to deal with this level of discomfort. With over 12 BMBs in the past 2 years, I’ve had one that was tender for months but it wasn’t nerve pain. My heart goes out to you!

You’ve been through so much with this already. I really hope the pain management injection helps you. Will this be a steroid? The area of the spinal column, L4/L5 does directly correlate to the nerve roots for the sciatic nerve. But for your comfort and peace of mind, it is certainly permissible before the injection to speak with the technician/clinician. Just so they are clear about where you are feeling the pain and where the intended target will be for the injection.

Will you please let us know how you feel after the appointment and you progress? Your experience will be valuable to other members on this forum.

I do have to ask…were the results of the biopsy good news for you?
Wishing you al the best, Lori.

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Oh my – 12 BMB in 2 years! Wow. I am happy that you're experience with the procedure has been pretty smooth. I will add you to my prayers.

Yes – radiates down my leg. That's good to know L4/5 associates with sciatic. I will make sure to have a convo with the dr before the injections. I am praying that I will get relief.

The BMB was due to high platelets, and turned into some mutation tests which dx as I have essential thrombocythemia with a CALR type 1 mutation.

Thank you. Your responses make me feel not so alone. I was worried that bc this thread is old I wouldn't hear from anyone. I will keep posting here after my injections next week. thank you again!!!

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@snacker1206 It’s my pleasure to be of help to you. This is the beauty of our Connect forum. You are never alone! We all have life journeys and stories to share. If we can help other along the way, it is a reward. ☺️

Thank you for you prayers. So far, my story has a happy middle…no ending in sight yet, thank God! ☺️ I do have another BMB coming up in July so finger’s crossed it is clean and well, no other complications. Honestly, I just feel gutted for you with the sciatic nerve pain you’re experiencing from your test on top of everything else. You are very strong…

With your diagnosis of essential thrombocythemia what is your treatment plan? Are there medications you need to take? We have a number of community members in Connect who also have ET and I’d like to introduce you to a few of them.
@dwlowrance @shenriq @candicemitchell320 @stevehurlburt @arianna
And a little information from Mayo Clinic’s site
https://www.mayoclinic.org/diseases-conditions/essential-thrombocythemia/diagnosis-treatment/drc-20361131
Take care and looking forward to hearing from you again. Stay strong and positive! Lori

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@loribmt

@snacker1206 It’s my pleasure to be of help to you. This is the beauty of our Connect forum. You are never alone! We all have life journeys and stories to share. If we can help other along the way, it is a reward. ☺️

Thank you for you prayers. So far, my story has a happy middle…no ending in sight yet, thank God! ☺️ I do have another BMB coming up in July so finger’s crossed it is clean and well, no other complications. Honestly, I just feel gutted for you with the sciatic nerve pain you’re experiencing from your test on top of everything else. You are very strong…

With your diagnosis of essential thrombocythemia what is your treatment plan? Are there medications you need to take? We have a number of community members in Connect who also have ET and I’d like to introduce you to a few of them.
@dwlowrance @shenriq @candicemitchell320 @stevehurlburt @arianna
And a little information from Mayo Clinic’s site
https://www.mayoclinic.org/diseases-conditions/essential-thrombocythemia/diagnosis-treatment/drc-20361131
Take care and looking forward to hearing from you again. Stay strong and positive! Lori

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Just finding this site. I have similar issues. Diagnosed with ET in Nov., had BMB mid nov. and started having burning calf and foot. I think it may be the sciatic nerve. Seeing my back orthopedist next week, hoping some PT will help. Not really sure if the burning is related or if Hydroxyurea could cause that but since I started having back sciatic pain I think that may be it. I have had lower back issues in the past on the same side though over the past year or two I had not had any issues until after the biopsy and medication start – 500 mg a day.

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@lea123

Just finding this site. I have similar issues. Diagnosed with ET in Nov., had BMB mid nov. and started having burning calf and foot. I think it may be the sciatic nerve. Seeing my back orthopedist next week, hoping some PT will help. Not really sure if the burning is related or if Hydroxyurea could cause that but since I started having back sciatic pain I think that may be it. I have had lower back issues in the past on the same side though over the past year or two I had not had any issues until after the biopsy and medication start – 500 mg a day.

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Hi, @lea123. Welcome to Mayo Connect. I’m happy you found our great community forum. I wish it was for a more pleasant reason than in search for relief of your burning calf and foot from sciatic pain. You’re right, this is a tough one to figure out if it’s from the BMB or the meds, since both happened at the same time. From reading the side effects of Hydroxyurea, I don’t see those mentioned on the list. But your symptoms are similar to some of the other discussions from people experiencing sciatic symptoms after a biopsy. It seems to be fairly rare though. I’ve had 13 BMBs and knock on wood, no issues.

Have you discussed this with your medical provider or whomever did the biopsy procedure? I hope you do get some relief after a visit with the physical therapist. Will you let me know?

You’re very newly diagnosed with Essential Thrombocythemia, having high platelets. There are several discussions in Connect in the Blood Cancers & Disorders group. I found a few links you might find useful.
https://connect.mayoclinic.org/discussion/calr-mutation-et-and-constitutional-symptoms/?pg=1#comment-276869
https://connect.mayoclinic.org/comment/276869/
https://www.mayoclinic.org/diseases-conditions/essential-thrombocythemia/symptoms-causes/syc-20361064

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@dazlin

I had it done at Mayo Clinic. I guess I can contact my care group, but I know its gonna be, you have to come in, maybe xray, maybe MRI doubt a simple diagnosis…So, I'm trying to give it time in case its something I did, and needs to heal. I know they said 1st week not to do anything strenuous, but this came on after 2nd week. Im kinda fed up with myself because its always something to bug me. It was just about completely all better, I wasn't feeling any discomfort…then BOOM!!
Thanks everyone…I'll post back in case I have to call. Was wondering if anything experienced this.

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I have been having burning pain in calf and foot when walking, on the side with the biopsy since bone marrow biopsy. Had some tests to rule out minor things, started having lower back pain and orthopedicst sent me to PT and they say it's the hip.. whole leg is hurting now, muscles. The burning, I keep thinking sciatic nerve pain from some kind of inflammation. Orthopedist says sciatic nerve not near there but I read about some rare things. It is leaving me unable to walk much and I am young and active, had hiked 4 miles right before the biopsy. I am going to press orthopedist to look further and be serious about injury from biopsy. It has been 3 months since the biopsy.

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@lea123

I have been having burning pain in calf and foot when walking, on the side with the biopsy since bone marrow biopsy. Had some tests to rule out minor things, started having lower back pain and orthopedicst sent me to PT and they say it's the hip.. whole leg is hurting now, muscles. The burning, I keep thinking sciatic nerve pain from some kind of inflammation. Orthopedist says sciatic nerve not near there but I read about some rare things. It is leaving me unable to walk much and I am young and active, had hiked 4 miles right before the biopsy. I am going to press orthopedist to look further and be serious about injury from biopsy. It has been 3 months since the biopsy.

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I'm sorry to hear that you continue to have pain. Did PT give you exercises to help alleviate the pain?

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I haven't heard many follow-up up stories from people. I had my BMB on 4/1 of this year and have been in constant pain, weakness, and numbness since. The lump in my bone seems to have gotten smaller though. My stories are similar to some of the others. CT scan and x-ray showed nothing, given inflammatories and muscle relaxers, icing, PT ect. Oddly enough I was able to get the pain to shift almost fully to my back for a week before it returned to my leg/glute. Several have told me it's just siatica, but I feel it should have subsided in 6 weeks. Trying to have hope it will. I was a very active person before this and can barely walk a quarter mile without limping.

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Hi all,
Just wanted to share my story and see if anyone else has any success stories if they've experienced what is happening with me, chronic pain and numbness after a Bone Marrow Biopsy.

On 4/1/22 I had a bone marrow biopsy on my right iliac crest due to chronic low white blood cells over the past 4 years. Thankfully they were able to rule out blood cancers, however I’ve now been left with severe pain starting from the middle of my glute down my leg. The pain sometimes turns to numbness and weakness, causing me to walk with a limp. It’s been a difficult adjustment as before this I was a very active person, working out 4-5x a week.
After the surgery I was told they had to try 3 times for marrow, which would increase recovery time. I’ve heard multiple attempts aren’t that abnormal though. I was not given much instruction on how long recovery would be, the Dr doing the attempt said it would be 1-2 days recovery and I could workout.

A week and a half later: I was still in pain but since I waited more than the recommended time, I tried a light run and some rowing. I had to stop due to the pain. Soon after (or maybe I missed it), a lump developed right above the biopsy incision site. It looked like bone sticking out. I called the onocologists office who performed the biopsy and was told to get imaging due.
2 and a half weeks since biopsy- ER Visit: I went to the ER and had an x-ray done, no bone fracture. A bedside ultrasound was done and I was told it was a hematoma with sciatica and sent home with stretches to do and Flexeril. The stretches make things worse and cause my leg to go even more numb.
4 weeks after biopsy- Followup to PCP: I was given a 5 day supply of presnidone and some more Flexeril since I told the dr that motrin seems to help a little. I tried this with not much relief. I had a CT scan done with and without contrast- nothing abnormal found.
5 weeks after biopsy- Oncologist followup: Oncologist reviewed the CT scan, xrays, looked at the lump which is actually a little bit smaller now. In his experience he said he’s never seen long lasting nerve pain but didn’t want to rule it out. He told me to try physical therapy.
6 weeks after- PT: Did some basic stretches and exercises, they seemed stumped but said I could try any exercise as long as it didn’t hurt.
At home I tried some light biking on my spin bike and a few hours later 95% of the pain moved to my lower back.. my leg felt better! I told this to PT and they said the pain is localizing. A week later they had me try squats and the pain returned to my leg, and my back is still in pain.
I’m stumped. I got a prescription for Celebrex now in hopes something can tame the inflammation. I know its only been 7 weeks, but the pain and loss of function is really impacting things and the lack of clarity from my drs has me feel a bit hopeless. I see a chiropractor tomorrow and get the prescription filled in.
Even thought it feels like sciatica sounds, it doesn’t seem to add up. I’ve been icing, using heat compresses, lots of anti inflammatories, stretches, limiting walking, increasing walking, etc (all with regular intervals, not all at once).
Sorry for the lengthiness, I hope someone is able to get something from this, or if you have and advice please let me know.

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@gonlee1

Hi all,
Just wanted to share my story and see if anyone else has any success stories if they've experienced what is happening with me, chronic pain and numbness after a Bone Marrow Biopsy.

On 4/1/22 I had a bone marrow biopsy on my right iliac crest due to chronic low white blood cells over the past 4 years. Thankfully they were able to rule out blood cancers, however I’ve now been left with severe pain starting from the middle of my glute down my leg. The pain sometimes turns to numbness and weakness, causing me to walk with a limp. It’s been a difficult adjustment as before this I was a very active person, working out 4-5x a week.
After the surgery I was told they had to try 3 times for marrow, which would increase recovery time. I’ve heard multiple attempts aren’t that abnormal though. I was not given much instruction on how long recovery would be, the Dr doing the attempt said it would be 1-2 days recovery and I could workout.

A week and a half later: I was still in pain but since I waited more than the recommended time, I tried a light run and some rowing. I had to stop due to the pain. Soon after (or maybe I missed it), a lump developed right above the biopsy incision site. It looked like bone sticking out. I called the onocologists office who performed the biopsy and was told to get imaging due.
2 and a half weeks since biopsy- ER Visit: I went to the ER and had an x-ray done, no bone fracture. A bedside ultrasound was done and I was told it was a hematoma with sciatica and sent home with stretches to do and Flexeril. The stretches make things worse and cause my leg to go even more numb.
4 weeks after biopsy- Followup to PCP: I was given a 5 day supply of presnidone and some more Flexeril since I told the dr that motrin seems to help a little. I tried this with not much relief. I had a CT scan done with and without contrast- nothing abnormal found.
5 weeks after biopsy- Oncologist followup: Oncologist reviewed the CT scan, xrays, looked at the lump which is actually a little bit smaller now. In his experience he said he’s never seen long lasting nerve pain but didn’t want to rule it out. He told me to try physical therapy.
6 weeks after- PT: Did some basic stretches and exercises, they seemed stumped but said I could try any exercise as long as it didn’t hurt.
At home I tried some light biking on my spin bike and a few hours later 95% of the pain moved to my lower back.. my leg felt better! I told this to PT and they said the pain is localizing. A week later they had me try squats and the pain returned to my leg, and my back is still in pain.
I’m stumped. I got a prescription for Celebrex now in hopes something can tame the inflammation. I know its only been 7 weeks, but the pain and loss of function is really impacting things and the lack of clarity from my drs has me feel a bit hopeless. I see a chiropractor tomorrow and get the prescription filled in.
Even thought it feels like sciatica sounds, it doesn’t seem to add up. I’ve been icing, using heat compresses, lots of anti inflammatories, stretches, limiting walking, increasing walking, etc (all with regular intervals, not all at once).
Sorry for the lengthiness, I hope someone is able to get something from this, or if you have and advice please let me know.

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@gonlee1, I appreciate all the details of your post. It sure sounds like you've pursued all avenues to get to the bottom of what is going on and to get back to your normal level of activity. I moved your message to this existed discussion:

– Delayed pain after bone marrow biopsy?? https://connect.mayoclinic.org/discussion/delayed-pain-after-bone-marrow-biopsy/

I did this so you can connect with @dazlin @snacker1206 and @lea123 who have had similar issues and hopefully will have updates about their experiences.

It sounds like you've got a good physical therapist and that you are dedicated to consistently doing the exercises prescribed. I know it's frustrating, but PT can take a long time to resolve issues. Dedication and consistency along with determination are your best tools. I hope others have more suggestions. I really hope continued PT, Celebrex and the chiropractor help.

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@gonlee1, I'm sorry your experiencing so much discomfort. I had my bone marrow biopsy 2 years ago. I had some soreness on the area for the 1st week. On the 7th day, I decided to bathe my 70 lb dog, lifting him in the tub…I believe that was a set back for me. I then had more pain for at least 2 weeks, if I remember correctly. Nothing down the leg. Just tender to sit or lay on the side of that hip area, and driving was uncomfortable. It slowly let up. It's my understanding there's a risk of slight fracture when they enter into the bone. I would insist on an MRI if I were you…sounds a bit long your not recovering.

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