Hi, @lea123. Welcome to Mayo Connect. I’m happy you found our great community forum. I wish it was for a more pleasant reason than in search for relief of your burning calf and foot from sciatic pain. You’re right, this is a tough one to figure out if it’s from the BMB or the meds, since both happened at the same time. From reading the side effects of Hydroxyurea, I don’t see those mentioned on the list. But your symptoms are similar to some of the other discussions from people experiencing sciatic symptoms after a biopsy. It seems to be fairly rare though. I’ve had 13 BMBs and knock on wood, no issues.

Have you discussed this with your medical provider or whomever did the biopsy procedure? I hope you do get some relief after a visit with the physical therapist. Will you let me know?

You’re very newly diagnosed with Essential Thrombocythemia, having high platelets. There are several discussions in Connect in the Blood Cancers & Disorders group. I found a few links you might find useful.