Anyone else on Daraxonrasib (RMC-6236)?

I have pancreatic cancer myself, but I have never taken daraxonrasib. My initial treatment was the triplet of gemcitabine, Abraxane and cisplatin for 18 weeks—two weeks on and one week off—followed by 33 days of radiation.

That's why I'm particularly interested in hearing firsthand experiences from people who are actually taking daraxonrasib. These new KRAS-targeted drugs are giving a lot of pancreatic cancer patients hope.

@mcharlesfrancis
Can you give us an update on your actual experience with daraxonrasib? My friend eagerly awaits this medication. Thanks.

My husband d is waiting for this drug too. I was
Blaming g his doctor for him not getti getting it. But I am finding out it takes awhile. The FDA needs to approve this drug if Itnis good. They are Messi g with people lives. Ugh. My prayers for everyone needing this drug.

Daraxonrasib is one of the most exciting new developments in pancreatic cancer, so I can understand why your oncologist is optimistic. If your husband is a good candidate based on his tumor's molecular profile, I hope it works very well for him.

The treatment break can definitely be unsettling, but sometimes it's intentional. Your oncologist may want him to recover from previous therapy before starting the new medication, or it may simply be part of the clinical or prescribing process while insurance approval is being completed. If you're concerned, don't hesitate to ask why the pause is necessary and whether they expect it to affect his treatment.

As for the rash, many patients on KRAS inhibitors develop skin reactions, but there are effective ways to manage them. Many oncologists start moisturizers early and may prescribe topical steroids or oral antibiotics if a rash develops. It's important to report any skin changes early rather than waiting until they become severe.

If he hasn't already had one, you might also ask whether his team plans to follow circulating tumor DNA (ctDNA) with a blood test such as Guardant360 or Signatera, in addition to CT scans and CA 19-9. These tests aren't appropriate for every patient, but they can sometimes provide additional information about how the cancer is responding.

I hope the approval comes through quickly and that daraxonrasib is everything we hope it will be. Please keep us posted—many of us are watching these new KRAS-targeted therapies with great interest.

@ljojimo Unfortunately, a few folks here are waiting on Rev Med to distribute the medication. Please let us know how things progress, so we can all learn from each other's process. Thanks.

@mcoplien My wife Trudi receives treatments at Mass General Hospital. She has been through both main chemo lines that now are no longer effective. She has been accepted for early access to daraxonrasib, but the start date to receive the pill is not secure. It depends on Rev Med delivering them to the queue of Mass General patients waiting for the pills to arrive. She has received from her oncologist the various medications to deal with the most common side effects, particularly rash and diarreah. (sp?). Meanwhile, her cancer marker continues to rise. It certainly is a waiting game. Thanks for getting back to me, and good luck with Mike's treatment.

@ljojimo
We are in Madison WI, Mike is followed by the Carbone Cancer Center. We were only contacted last Friday. They emailed us the informed consent which we went over with them today. They said Daraxonrasib is in the process of being approved by the FDA, this is according to the Gastrointestinal Research Team at the UW Hospital in Madison. Noelle LoConte is the head physician. FYI - Mike still has to be screened (blood tests and medical history review) to make sure he is a candidate for the extended access program. That will probably take a week... then they order the medication which they told us today, this could take 2-3 weeks to get once it is ordered. Quite the waiting game.

@mcoplien Good luck with your consent form and moving the process along. Please let us know how things go next week? Thanks.

@caldy53 Hi and welcome to Mayo Connect. You seem to be following the progress of Daraxonrasib's FDA approval. Are you a candidate for it if it is approved?

@mcoplien Hi there, do you have any more information on the FDA approval coming soon? What was your source? Thanks very much for any additional details.