@mcoplien My wife Trudi receives treatments at Mass General Hospital. She has been through both main chemo lines that now are no longer effective. She has been accepted for early access to daraxonrasib, but the start date to receive the pill is not secure. It depends on Rev Med delivering them to the queue of Mass General patients waiting for the pills to arrive. She has received from her oncologist the various medications to deal with the most common side effects, particularly rash and diarreah. (sp?). Meanwhile, her cancer marker continues to rise. It certainly is a waiting game. Thanks for getting back to me, and good luck with Mike's treatment.