Has anyone ever been on Duloxetine (Cymbalta) for nerve pain?

This drug has lots of serotonin in it. If you are taking other drugs with serotonin in them, beware.I had an adverse reaction called serotonin syndrome. Too much serotonin in your system can be life threatening. Lots of anxiety, nausea and agitation. Contacted my doctor and then stopped it. Too dangerous for me to take.

The Pain Clinic recommended that my G.P. put me on Duloxetine (Cymbalta) and after titrating down from Amitriptyline and Dihydrocodeine, he gradually titrated me up to 60 mg Duloxatine in the morning and, another 60 mg Duloxetine in the evening. I also now have a weekly Bupronorphine patch, that delivers 10micrograms every hour. Together, the two meds just take the edge off the pain to a point that I can deal with it. The first month was up and down and the Duloxatine played havoc with my stomach but, I stuck with it and, gradually things began settling down. Now I have no meds side effects……😊

I'm glad Duloxetine is working for you. I started it a little over a month ago. I don't think it's helping with my back pain, but it sure helps my anxiety. I have felt nausea since starting it. How long did it take for your stomach issues to go away?

Thanks Dolly 🙂
I haven’t heard of the patch. I’m going to ask my doc about it. You’re dealing with nerve pain and discomfort from neuropathy, right?

Hi Gail, I have fibromyalgia, along with osteoarthritis throughout my body with left and right hip replacements. degenerative disc disease in my lower back, stage 3 CKD plus,
severe late onset asthma, Factor V Leiden (a blood clotting gene) and, left valve hypertrophy - so basically, what my doctor refers to as ‘a lady with a complex medical history’. I have lived with pain since the age of 11, when I had a slipped epiphysis - that wasn’t diagnosed until I was 13. It been pretty much different surgeries up until the age of 28. 🤦‍♀️🤣😂. I’m now rapidly approaching 79, still married to the wonderful man I met a week after my 16th birthday - I’m still livin’ so guess I’m okay.🤭🤣😂

Hello @besmith57 - once I hit the 60mg - both am and pm, my stomach - that had been causing mild to middling issues - seemed to go into overdrive.
However - at that level - and possibly because of the titrating - it thankfully didn't last very long. From the first low level of Duloxatine, to everything settling down took approximately 8 - 10 weeks. With the addition of the Bupronorphine the pain was taken to a level that I could handle….😊

I’m sorry to learn of all your conditions and what you’ve been through. And for mixing up which group I was in. I’m mainly in the neuropathy group here. I’m glad you’ve endured and found some relief! Take good care.

Thanks for replying. I take 60 mg a day. My PCP upped it to 90mg and I was so dizzy the next day I couldn't walk. I went back to 60mg. I also take Lexapro. So are you taking 60mg in the morning and 60mg at night? I was a little confused about your dosage. Since I've only been on it for a month and a half maybe there is hope the nausea will go away. I will google the Buprenorphine because I don't know what that is. I'm doing PT also, but that doesn't seem to be helping either. I am taking it with food now thinking that might help. I'm sorry you've had to deal with pain for so long. What a great love story you have!! Congratulations!

My experience was just negative reactions - Cymbalta caused no energy, then depression, more pain, more in R shoulder (torn rotary) although summer is usually better. My vision started to get worse and also pain in R eye, slight hand shaking which got worse. I got headaches starting day 3. Teeth started to bleed when I brushed. Problems with bladder especially at night.

@1kay2 - I’m so sorry that you appear to have reacted so badly to Duloxetine (Cymbalta). My only short lived problem, was stomach issues (mainly feeling nauseous) but having stuck with it that resolved itself after a couple of months. Guess it proves that medication is definitely NOT a ‘one size fits all’.