Collagen for bone loss? Effective?

Posted by mschlink @mschlink, Mar 11 4:48pm

Has anyone tried collagen for bone loss?

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Profile picture for mpc1 @mpc1

The company is Gelita. Dexa 6/25, stable since 2023.
My Dexa results are:
Bone Mineral Density (BMD) analysis performed on GE Lunar iDXA with serial number ME+212650.

FINDINGS:
Left Hip:

Femur Neck: BMD = 0.842 g/cm2
T-score = -1.4 Z-score = 0.3

Total Hip: BMD = 0.927 g/cm2
T-score = -0.6 Z-score = 0.8

Right Hip:

Femur Neck: BMD = 0.831 g/cm2
T-score = -1.5 Z-score = 0.2

Total Hip: BMD = 0.929 g/cm2
T-score = -0.6 Z-score = 0.9

Lumbar Spine:

L1: BMD = 0.768 g/cm2
L2: BMD = 0.798 g/cm2
L3: BMD = 0.884 g/cm2
L4: BMD = 0.732 g/cm2

Total Lumbar Spine (L1-L4 (L3)): BMD = 0.763 g/cm2
T-score = -3.4 Z-score = -1.6

Trabecular Bone Score:
L1-L4 (L3): TBS = 1.225

< 1.23: low
1.23 -1.31: borderline
> 1.31: normal

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That is good news that you're BMD has remained stable for 2 years. Your Dexa spine T score is similar to mine which was -3.5 almost 2 years ago, but my hip was -2.8. My REMS Echolight spine was slightly better 6 months later at -3 and hip -2, then spine increased to -2.6 and hip to -2.3 10 months later. I see you had a TBS done which I requested and am anxiously awaiting along with a follow-up DEXA. I am also 68.

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Profile picture for debbie1956 @debbie1956

That is good news that you're BMD has remained stable for 2 years. Your Dexa spine T score is similar to mine which was -3.5 almost 2 years ago, but my hip was -2.8. My REMS Echolight spine was slightly better 6 months later at -3 and hip -2, then spine increased to -2.6 and hip to -2.3 10 months later. I see you had a TBS done which I requested and am anxiously awaiting along with a follow-up DEXA. I am also 68.

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I am not going get a REMS until doctors begin to accept or prescribe based on REMS. I am not saying I do not trust the REMS, just that it is not accepted in the US medical establishment. I also do not see a physician for my OP, because I am confident right now that what I am doing is positive. No fracture history and no cancer history. My younger sister started on meds years ago and never had any solid response until a year of evenity. She was advised to go on prolia as a follow up and chose not to. Her lumbar spine is 5.1 now and her doc is advising reclast. She is undecided. She is in a tough spot because she has taken all these meds, and yet never fractured. It is a lot of years to be on these meds. Good luck

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Profile picture for mpc1 @mpc1

I am not going get a REMS until doctors begin to accept or prescribe based on REMS. I am not saying I do not trust the REMS, just that it is not accepted in the US medical establishment. I also do not see a physician for my OP, because I am confident right now that what I am doing is positive. No fracture history and no cancer history. My younger sister started on meds years ago and never had any solid response until a year of evenity. She was advised to go on prolia as a follow up and chose not to. Her lumbar spine is 5.1 now and her doc is advising reclast. She is undecided. She is in a tough spot because she has taken all these meds, and yet never fractured. It is a lot of years to be on these meds. Good luck

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My functional medicine doctor, certified by N. A. Menopause Society,
recognizes REMS, but I had it done for my own interest before I consulted
her as it provides a bone quality score as well, is well accepted in Europe
and relatively low cost in Canada. Fortunately I have so far not fractured
either and hope to continue to avoid medication. As I mentioned, the BHRT,
prescribed by the functional medicine physician, reduced my CTX bone
turnover score by 80 percent which makes me confident I've stopped the
rapid bone loss.That is unfortunate your sister didn't benefit initially
from the medication. Do you mean that her current spine level is -5.1 after
Evenity? I wish you continuing success in your journey.

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Two years after Evenity, she had the loss. It is all so confusing, and complicated.
Something’s it seems like throwing darts at a wall.
Best to you!

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Profile picture for mpc1 @mpc1

The company is Gelita. Dexa 6/25, stable since 2023.
My Dexa results are:
Bone Mineral Density (BMD) analysis performed on GE Lunar iDXA with serial number ME+212650.

FINDINGS:
Left Hip:

Femur Neck: BMD = 0.842 g/cm2
T-score = -1.4 Z-score = 0.3

Total Hip: BMD = 0.927 g/cm2
T-score = -0.6 Z-score = 0.8

Right Hip:

Femur Neck: BMD = 0.831 g/cm2
T-score = -1.5 Z-score = 0.2

Total Hip: BMD = 0.929 g/cm2
T-score = -0.6 Z-score = 0.9

Lumbar Spine:

L1: BMD = 0.768 g/cm2
L2: BMD = 0.798 g/cm2
L3: BMD = 0.884 g/cm2
L4: BMD = 0.732 g/cm2

Total Lumbar Spine (L1-L4 (L3)): BMD = 0.763 g/cm2
T-score = -3.4 Z-score = -1.6

Trabecular Bone Score:
L1-L4 (L3): TBS = 1.225

< 1.23: low
1.23 -1.31: borderline
> 1.31: normal

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To @mpc1 @debbie1956 I was just diagnosed this year at 63 YO. My spine and hip DeXa score are similar to yours (spine -3.2, hip -2-2). I have also opted not to go on medications. Can you tell me what actions you are taking to slow down/reverse your bone loss?

I had to ask my endocrinologist to do the tests to rule out any underlying causes. Vitamin D deficiency and low intake of calcium were the only items of concern.

I just started collagen this month. I use OsteoNaturals sold by Dr McCormick. I also eat a balanced diet, trying to get more than the minimum amount recommended by the RDA of calcium and proteins. I make sure I include prunes (everyday), kale, salmon, apple cider vinegar, broccoli, lean proteins, yogurt, cheeses, fermented foods etc. into my diet. I take a Vitamin D supplement (it has Vitamin D3, K1,K2). I average 8,000 steps a day. I do Dr Loren Fishman’s 12 yoga poses every other day. I lift weights 2-3 times a week, although I haven’t gone past 10 pounds yet. I do balancing exercises. I also play golf 2-3 times a week!!

I only weigh 100 pounds, and have read that thin and fine boned women’s DEXA scores can be skewed to be worse than they actually are because of the small size of their bones. I wish there was a definitive way to find out!! My CTX score is not crazy (479) so I am not rapidly destroying bone; I am trying to work on this by looking for foods that lower osteoclast activity. My P1NP is 63.

Reading @mpc1 story, I feel as if OP has a lot to do with genetics. My grandmother and mother both had OP. They never went on medications; it wasn’t invented yet for my grandma which was probably a good thing! She fractured her wrist in her 80s and she lived until she was 95. My mother refused medication in the 1990s. She fractured just last year at 90 years old when she tripped and fell; she had a hip replacement and she was walking the next day!!. She still drives!! I hope my genes take after them!!

I am going to get a DEXA next year even if I have to pay for it and see if my efforts help. I will also look for a place that can do a TBS score. If I get worse, it will be a difficult decision about medication because I feel strong and am so active now. If I am holding steady, then it will be a win because all the other things I am doing is beneficial for my body. I feel scared about all the side effects people experience with the meds, and it’s not from reading about it!! I have several friends who have taken them (fosamax, reclast, prolia), and they have joint pains, flu like symptoms, and 1 of them has experienced multiple fractures while on Prolia!! My friend who is on Prolia has had skin and eye problems (she never has them before), and this is a person who was very active; she lifted weights, would jog for miles!!

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Profile picture for shelldct1 @shelldct1

To @mpc1 @debbie1956 I was just diagnosed this year at 63 YO. My spine and hip DeXa score are similar to yours (spine -3.2, hip -2-2). I have also opted not to go on medications. Can you tell me what actions you are taking to slow down/reverse your bone loss?

I had to ask my endocrinologist to do the tests to rule out any underlying causes. Vitamin D deficiency and low intake of calcium were the only items of concern.

I just started collagen this month. I use OsteoNaturals sold by Dr McCormick. I also eat a balanced diet, trying to get more than the minimum amount recommended by the RDA of calcium and proteins. I make sure I include prunes (everyday), kale, salmon, apple cider vinegar, broccoli, lean proteins, yogurt, cheeses, fermented foods etc. into my diet. I take a Vitamin D supplement (it has Vitamin D3, K1,K2). I average 8,000 steps a day. I do Dr Loren Fishman’s 12 yoga poses every other day. I lift weights 2-3 times a week, although I haven’t gone past 10 pounds yet. I do balancing exercises. I also play golf 2-3 times a week!!

I only weigh 100 pounds, and have read that thin and fine boned women’s DEXA scores can be skewed to be worse than they actually are because of the small size of their bones. I wish there was a definitive way to find out!! My CTX score is not crazy (479) so I am not rapidly destroying bone; I am trying to work on this by looking for foods that lower osteoclast activity. My P1NP is 63.

Reading @mpc1 story, I feel as if OP has a lot to do with genetics. My grandmother and mother both had OP. They never went on medications; it wasn’t invented yet for my grandma which was probably a good thing! She fractured her wrist in her 80s and she lived until she was 95. My mother refused medication in the 1990s. She fractured just last year at 90 years old when she tripped and fell; she had a hip replacement and she was walking the next day!!. She still drives!! I hope my genes take after them!!

I am going to get a DEXA next year even if I have to pay for it and see if my efforts help. I will also look for a place that can do a TBS score. If I get worse, it will be a difficult decision about medication because I feel strong and am so active now. If I am holding steady, then it will be a win because all the other things I am doing is beneficial for my body. I feel scared about all the side effects people experience with the meds, and it’s not from reading about it!! I have several friends who have taken them (fosamax, reclast, prolia), and they have joint pains, flu like symptoms, and 1 of them has experienced multiple fractures while on Prolia!! My friend who is on Prolia has had skin and eye problems (she never has them before), and this is a person who was very active; she lifted weights, would jog for miles!!

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I just started BHRT about a month ago and am hoping doc will increase estradiol when I see her in 3 months. Dose I am on now is not bone protective. I also use Osteonaturals collagen. I get most of my calcium from my diet, stay active, take a Vit D supplement and a low dose of K2. I have lifted weights on and off but am currently beta testing an app for building bone strength. Nothing else.

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Profile picture for drsuefowler @drsuefowler

Did this study use a specific collagen eg Fortibone?

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Yes. Here is a quote from the study: "2.7. Protein Supplementation
For this study, a mixture of specific bioactive collagen peptides (SCP) with a mean molecular weight of approx. 5 kDa, derived from a complex multi-step hydrolysis of collagen, was used (FORTIBONE®, GELITA AG, Eberbach, Germany). The sachets containing 5 g SCP or placebo (maltodextrin, CARGILL, Paris, France) were identical in appearance and the products were equal in flavor and texture."

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Profile picture for mpc1 @mpc1

This is a very small study, and funded partly by Gelita, the Fortibone company.
I use a product with Fortibone, but I also do a lot of other things to remain strong and avoid fracture.

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I just wanted to express my disagreement about a conflict of interest with Gelida.
https://www.academia.edu/69834267/Specific_Bioactive_Collagen_Peptides_in_Osteopenia_and_Osteoporosis_Long_Term_Observation_in_Postmenopausal_Women?auto=download
At the end of the article published in the prestigious BJM journal authors state: No potential conflict of interest relevant to this article
was reported. SO has given scientific lectures that were in
parts supported by the GELITA AG. He is also co-inventor
of patents concerning the use of collagen peptides. All
procedures performed in studies involving human partici-
pants were in accordance with the ethical standards of the
institutional and/or national research committee, and with
the 1964 Helsinki declaration and its later amendments or
comparable ethical standards. The funders had no role in
the design of the study; in the collection, analyses, or inter-
pretation of data; in the writing of the manuscript, or in
the decision to publish the results.
Look, to make a wrong statement can ruin the researcher´s carrier, and it is not worth it.

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Profile picture for melia7 @melia7

I just wanted to express my disagreement about a conflict of interest with Gelida.
https://www.academia.edu/69834267/Specific_Bioactive_Collagen_Peptides_in_Osteopenia_and_Osteoporosis_Long_Term_Observation_in_Postmenopausal_Women?auto=download
At the end of the article published in the prestigious BJM journal authors state: No potential conflict of interest relevant to this article
was reported. SO has given scientific lectures that were in
parts supported by the GELITA AG. He is also co-inventor
of patents concerning the use of collagen peptides. All
procedures performed in studies involving human partici-
pants were in accordance with the ethical standards of the
institutional and/or national research committee, and with
the 1964 Helsinki declaration and its later amendments or
comparable ethical standards. The funders had no role in
the design of the study; in the collection, analyses, or inter-
pretation of data; in the writing of the manuscript, or in
the decision to publish the results.
Look, to make a wrong statement can ruin the researcher´s carrier, and it is not worth it.

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It remains a very small study, but thank you for pointing that out. 31 people in a study is very small.

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Profile picture for daisy17 @daisy17

Yes. Here is a quote from the study: "2.7. Protein Supplementation
For this study, a mixture of specific bioactive collagen peptides (SCP) with a mean molecular weight of approx. 5 kDa, derived from a complex multi-step hydrolysis of collagen, was used (FORTIBONE®, GELITA AG, Eberbach, Germany). The sachets containing 5 g SCP or placebo (maltodextrin, CARGILL, Paris, France) were identical in appearance and the products were equal in flavor and texture."

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@daisy17, Thanks so much for your comprehensive reply. I use Great Lakes Collagen which I assume hasn't been studied. I'm trying to decide if I should switch to Fortibone.

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