Uterine clear-cell carcinoma, chemo treatment unknowns

Posted by vika @vika, Mar 20 8:01am

Hi there! My mum has been diagnosed with Carcinoma of uterine body pT3bN1aM1 (Metastases of clear cell carcinoma in one of the ovaries, uterine tube, the greater omentum, lymph nodes). On 1st of March she had surgery: radical hysterectomy, lymph node dissection along the iliac blood vessels, omentectomy (Kyiv, Ukraine). She was discharged from the hospital and recommended chemotherapy. In different clinics in Kyiv we were offered 4 or 6 rounds of Carboplatin + Paclitaxel. Is it a right (internationally proved) schema?

One complication for choosing treatment is deep vein thrombosis (DVT) in her legs. In one clinic we were told to wait 2 weeks taking Rivaroxaban 20 mg until starting the chemo. In another clinic, we were told to start chemo next week because it’s dangerous to wait in the long term. I’m very concerned about different suggestions, considering and thinking about the long term and short term risks…
I’ll really appreciate it if you could share any useful info/share your experience… Thanks!!

@vika Welcome to Mayo Clinic Connect, a place to give and get support.

I'm sorry to hear about your mother. It's obviously important that you gather as much information as possible, so that you and your mother can make the best informed decision. You will notice that I added your question to a discussion that was already established. You may wish to scroll through the posts and look for information and member connections. You will also notice before that the director has instructions on how to join a support group. You may find this helpful and it may be a way for you to connect and gather more information.

May I ask, is your mother planning to have treatment at the same place of the surgery or are you also looking into facility options?

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How nice to hear from Lviv. My father is from there and my cousin is head of cardiology at a local hospital in Kviv, Dr, Yuri Starko.

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@ejohn

Hello, I am looking to hear more about Uterine Clear Cell cancer. I had a radical hysterctomy last fall with clear cell in 1 lymph node, making it stage III for me. I am about to have my last chemo and then consult with the radiologist. Interested to learn more about the radiation treatments others had, where, the side effects and results. How long to feel you were recovered from chemo and radiation. Thank you

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Hi @ejohn, how are you? May I ask you what exact drugs for chemo did you get? How was it? I'm asking for my mum, she has a similar diagnosis and has radical hysterctomy as well. Also how long after surgery did you start the first chemo round? Did you have any issues with deep vein thrombosis? Sorry for the very specific questions, feel free to ignore it If I asked too much. Thanks

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@erikas

@vika Welcome to Mayo Clinic Connect, a place to give and get support.

I'm sorry to hear about your mother. It's obviously important that you gather as much information as possible, so that you and your mother can make the best informed decision. You will notice that I added your question to a discussion that was already established. You may wish to scroll through the posts and look for information and member connections. You will also notice before that the director has instructions on how to join a support group. You may find this helpful and it may be a way for you to connect and gather more information.

May I ask, is your mother planning to have treatment at the same place of the surgery or are you also looking into facility options?

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@erikas Thanks for adding the relevant information for me! Unfortunately, she can't get chemo treatment at the same place so we are looking for facility options. And it's a bit hard because different places offer different options for treatment.

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@vika

Hi @ejohn, how are you? May I ask you what exact drugs for chemo did you get? How was it? I'm asking for my mum, she has a similar diagnosis and has radical hysterctomy as well. Also how long after surgery did you start the first chemo round? Did you have any issues with deep vein thrombosis? Sorry for the very specific questions, feel free to ignore it If I asked too much. Thanks

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Hello @vika, I am sorry I didn't reply sooner. I had 6 rounds of carboplatin and taxol. It was just not too bad for me. I had bone pain that was the worst with the first treatment. I had fatigue that progressively increased with treatment but wasn't too bad. there were days I couldn't stand for more than 10 minutes, but it was all okay, I just got prepared it would get worse. i had very little nausea, mostly after the last treatment. That is usually a big side effect. I still have numbness and tingling in my fingers and toes but am hopeful for continued improvement. I didn't start chemo for about 5 weeks. I have to look. i was in a hurry but you also want to make sure the wound is healed, and that is mainly the internal vaginal cuff. I did not have deep vein thrombosis. Please feel free to ask, I would be glad to help in anyway I can. Eileen

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@colleenyoung

Hi @ejohn and @cichocki06, I'm wondering if you decided to have radiation and have you started?

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I had my practice radiation today and start tomorrow. Planned for 25 tx plus 2 brachy to the vaginal cuff. Ready for the next step and closer to being healed.

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Hello @vika, I am sorry I missed your posts and did not reply sooner. I am wondering if your mother did start chemo already? I had 4-5 weeks in between but maybe with hers they are pushing on since it sounds like it was outside the lymph nodes. My previous reply to your post to me explained why they had me wait a few weeks. I had one positive lymph node but everything else was clear. I hope it is going well and decisions are clear. Eileen

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@ejohn

Hello @vika, I am sorry I didn't reply sooner. I had 6 rounds of carboplatin and taxol. It was just not too bad for me. I had bone pain that was the worst with the first treatment. I had fatigue that progressively increased with treatment but wasn't too bad. there were days I couldn't stand for more than 10 minutes, but it was all okay, I just got prepared it would get worse. i had very little nausea, mostly after the last treatment. That is usually a big side effect. I still have numbness and tingling in my fingers and toes but am hopeful for continued improvement. I didn't start chemo for about 5 weeks. I have to look. i was in a hurry but you also want to make sure the wound is healed, and that is mainly the internal vaginal cuff. I did not have deep vein thrombosis. Please feel free to ask, I would be glad to help in anyway I can. Eileen

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Thanks for sharing this. I just had my fourth round o carboplatin and taxol. More tired and sores in mouth started. I was wondering what to expect

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@ejohn

I had my practice radiation today and start tomorrow. Planned for 25 tx plus 2 brachy to the vaginal cuff. Ready for the next step and closer to being healed.

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@ejohn, just a quick note to say I'm thinking about you today as you start radiation for real. When do you get the brachy treatment?

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@ejohn thanks a lot for sharing this! My mum started her chemo this week, after 4w after the surgery.
I also together with @colleenyoung thinking about you and wish you the very best with further treatment! 🙏

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@miriam57

Thanks for sharing this. I just had my fourth round o carboplatin and taxol. More tired and sores in mouth started. I was wondering what to expect

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How is it going Miriam? Sorry to hear about the sores. I did not have that. But I did rinse with salt water and baking soda daily. I just had a few rough days, with fatigue and joint pain. My 6th treatment I had some nausea along with the fatigue. How many rounds are you having? Eileen

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@vika

@ejohn thanks a lot for sharing this! My mum started her chemo this week, after 4w after the surgery.
I also together with @colleenyoung thinking about you and wish you the very best with further treatment! 🙏

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How is your mum doing Vika? Thank you for the encouragement! Eileen

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