What's your experience wtih Brinsupr (brensocatib)?

I have been on brinsupri for 2 1/2 months. I had such high hopes for this new medicine but unfortunately I think I need to stop taking it. My cough has gotten so much worse and a lot of wheezing going on. A month ago my doctor had me take a round of prednisone because of the wheezing. I’ve been coughing up more phlegm but it’s usually during the night, which is a nuisance. Is there anyone else out there who has had similar results? I also do Ohtuvahre and the levabuteral/ saline with a nebulizer twice a day.

@faymk Wheezing sounds like asthma, though I have asthma, I rarely wheeze but asthma can get me coughing ALL day long and for months. I take both Brinsupri and recently restarted Montelukast-though it doesn't work for many. For me leukotrienes were always an issue, particularly in the spring and fall. I started Brinsupri 3 months ago and I started noticing an improvement at about 4 weeks. That's not really that unusual and I believe it has to do with the extent that neutrophil enzymes impact one or another. Unfortunately, I'm now getting skin issues. Panther RX pharmacists are hearing that many are seeing effects within the 1-2 month timeframe, but not everyone. I think it's worth a call to INSMED, who continue to collect data from many of us (and their pharmacy partner, Panther RX). I would think by now they would have a good handle on how many start feeling improvement within 1.2, or 3 months and up through 6 months.

@kathyjjb What kind of skin issues After 2 months on the medication I have a small but very itchy rash on my forearm.

So I am now into the 2 month of Brinsupri 10mg & I honestly feeling worse then better. The common cold side effect I got, is now into week #2. The amount of cough seems endless & the mucus production is crazy. It seems I begin my day coughing & end it the same way. I have short stints of no coughing, but not enough to feel it am getting prolonged period of relief. Just wondering if others saw things get worse before it got better.

So I am now into the 2 month of Brinsupri 10mg & I honestly feeling worse then better. The common cold side effect I got, is now into week #2. The amount of cough seems endless & the mucus production is crazy. It seems I begin my day coughing & end it the same way. I have short stints of no coughing, but not enough to feel it am getting prolonged period of relief. Just wondering if others saw things get worse before it got better.

So I am now into the 2 month of Brinsupri 10mg & I honestly feeling worse then better. The common cold side effect I got, is now into week #2. The amount of cough seems endless & the mucus production is crazy. It seems I begin my day coughing & end it the same way. I have short stints of no coughing, but not enough to feel it am getting prolonged period of relief. Just wondering if others saw things get worse before it got better.

@faymk
Yes, the Bronchiectasis seemed to get a bit more intense before it got better. 6+ months before full benefits are realized. Sometimes it felt like two steps forward and three steps back. A lot of plateaus. Even on Brinsupri over eight months I often wake up in the morning with a cough feeling the need to clear my lungs. How often are you doing airway clearance? My new record is being able to use the nebulizer and clear my lungs in 20 minutes! Previously unheard of.

@scoop
I use the Levalbuteral solution as well as Ohtuvayre daily with the nebulizer

@faymk
I have wondered about Ohtuvayre. How is it going? Has it helped you? Can you tell a difference? Ohtuvayre is in clinical trials for bronchiectasis but has been approved for COPD. Were you in the trials? I cannot be in the trial because I am on Brinsupri and I would have to be Brinsupri free for 3 months, so I'll guess I'll wait for it to be approved. I'd enjoy hearing from you.