@faymk Wheezing sounds like asthma, though I have asthma, I rarely wheeze but asthma can get me coughing ALL day long and for months. I take both Brinsupri and recently restarted Montelukast-though it doesn't work for many. For me leukotrienes were always an issue, particularly in the spring and fall. I started Brinsupri 3 months ago and I started noticing an improvement at about 4 weeks. That's not really that unusual and I believe it has to do with the extent that neutrophil enzymes impact one or another. Unfortunately, I'm now getting skin issues. Panther RX pharmacists are hearing that many are seeing effects within the 1-2 month timeframe, but not everyone. I think it's worth a call to INSMED, who continue to collect data from many of us (and their pharmacy partner, Panther RX). I would think by now they would have a good handle on how many start feeling improvement within 1.2, or 3 months and up through 6 months.