Brinsupri follow-up

I just wanted to share with you that after about 12 days on Brinsupri I have become cautiously optimistic.
I have noticed a surprising increase in my energy, less mucus, particularly green mucus. This was very surprising to me because as mentioned by other members, I didn’t expect any results or improvements until 4 to 6 weeks.’
I have cut back on my air clearance, particularly the best Vest because I fell and injured my back and could not cope with putting it on
Also, I missed one day of evening air clearance… surprisingly, I have Not noticed any difference even with the reduction in air clearance
Nevertheless, I have continued to feel much more energetic and strong. I never had much of a cough, but I do believe this could be a very promising drug for most of you.

I have upped my regimen slowly. I’m really fast walking 30 to 40 minutes and now I am able to do a little bit of a jog
This is truly a hopeful experience
Also, the study concluded that there was only a 20% reduction in flares and exacerbations, etc.
That may be the case, but overall, it has been a very positive experience
Minimal side effects Except for some annoying headaches, which disappeared after the first week
PS I’m on the 10 mg dose
I’ve tried it within without food and it doesn’t seem to make a difference although I do take it in the morning
I hope all of you have the opportunity too. Try this very promising medication.
It’s worth the hassle of getting it.
I’m terrified that this will change because really I haven’t felt this good in two years since I was first diagnosed with chronic pneumonia with abscess, etc.
Best regards to all Jill Crawford

Delighted to know you are experiencing improvements from Brinsupri! My experience has been similar to yours except I have not missed a clearance session (yet). My AC sessions are now around 30 minutes vs 45+ minutes. It's a relief to have less and lighter color mucus. More energy, less coughing, a good thing!

This week I'm paying attention to Dr. Chalmers talk at the annual CHEST meeting. His talk entitled, "Effect of Brensocatib on Computed Tomography Outcomes in Patients with Non-Cystic Fibrosis Bronchiectasis: An Analysis of the ASPEN Trial". That would be quite something if research is seeing [positive] changes in CT scans of those on Brinsupri. We'll have to wait to find out. Fingers crossed.

@scoop With as many people it appears are going on Brinsupri in all the Centers of Excellence, hopefully, good results and information will be flowing to all of us from centers and therefore to Dr. Daily at NJH who from my understanding is coordinating and gathering the information. Have you heard that about Dr. Daily at NJH?
Barbara

I’m on day 15 of starting Brinsupri. Yesterday I thought I might be improving and today I definitely see an improvement! Not coughing nearly as much and I had my first good nights sleep in a while. I was having quite a few excerbations and at the end of one when I started. Even the mucus from Mac has lessened. Had my regular tooth cleaning and dentist went over how to help prevent gingivitis. So we’ll see what happens from here on. Marilyn K

@marilynk what dosage are you on 10mg or 25mg?

Delighted to know you are experiencing improvements from Brinsupri! My experience has been similar to yours except I have not missed a clearance session (yet). My AC sessions are now around 30 minutes vs 45+ minutes. It's a relief to have less and lighter color mucus. More energy, less coughing, a good thing!

This week I'm paying attention to Dr. Chalmers talk at the annual CHEST meeting. His talk entitled, "Effect of Brensocatib on Computed Tomography Outcomes in Patients with Non-Cystic Fibrosis Bronchiectasis: An Analysis of the ASPEN Trial". That would be quite something if research is seeing [positive] changes in CT scans of those on Brinsupri. We'll have to wait to find out. Fingers crossed.

@scoop
What do you mean by clearing (AC) sessions?

Delighted to know you are experiencing improvements from Brinsupri! My experience has been similar to yours except I have not missed a clearance session (yet). My AC sessions are now around 30 minutes vs 45+ minutes. It's a relief to have less and lighter color mucus. More energy, less coughing, a good thing!

This week I'm paying attention to Dr. Chalmers talk at the annual CHEST meeting. His talk entitled, "Effect of Brensocatib on Computed Tomography Outcomes in Patients with Non-Cystic Fibrosis Bronchiectasis: An Analysis of the ASPEN Trial". That would be quite something if research is seeing [positive] changes in CT scans of those on Brinsupri. We'll have to wait to find out. Fingers crossed.

I just wanted to share with you that after about 12 days on Brinsupri I have become cautiously optimistic.
I have noticed a surprising increase in my energy, less mucus, particularly green mucus. This was very surprising to me because as mentioned by other members, I didn’t expect any results or improvements until 4 to 6 weeks.’
I have cut back on my air clearance, particularly the best Vest because I fell and injured my back and could not cope with putting it on
Also, I missed one day of evening air clearance… surprisingly, I have Not noticed any difference even with the reduction in air clearance
Nevertheless, I have continued to feel much more energetic and strong. I never had much of a cough, but I do believe this could be a very promising drug for most of you.

I have upped my regimen slowly. I’m really fast walking 30 to 40 minutes and now I am able to do a little bit of a jog
This is truly a hopeful experience
Also, the study concluded that there was only a 20% reduction in flares and exacerbations, etc.
That may be the case, but overall, it has been a very positive experience
Minimal side effects Except for some annoying headaches, which disappeared after the first week
PS I’m on the 10 mg dose
I’ve tried it within without food and it doesn’t seem to make a difference although I do take it in the morning
I hope all of you have the opportunity too. Try this very promising medication.
It’s worth the hassle of getting it.
I’m terrified that this will change because really I haven’t felt this good in two years since I was first diagnosed with chronic pneumonia with abscess, etc.
Best regards to all Jill Crawford

@scoop
Great! Please report back on the CT results!