Brinsupri experience after 3+ months

@maryjanechilds

Thank you Mary Jane. I really appreciate your information.

Has anyone experienced getting an upper respiratory infection after taking two months of Brinsupri? I just did 3 days ago and it is pretty bad. Doctor prescribed antibiotics and left it up to me if I wanted to continue taking Brinsupri. I'm not sure what to do. Any info would be most helpful.

@irenea8
At the Orlando conference, I spoke with a doctor who has treated more than 400 people with Brinsupri, and he shared something very similar to what you’re saying. At this point, they do not fully understand why. Hopefully, over the next year or so, as more data are collected and analyzed, we’ll have a clearer understanding of what factors influence who benefits most from the medication.

enjoy the day,
Linda Esposito

@sueinmn I have actually have more of a small cough than before I started taking it. I am trying to get my pulmonologist to switch me to the lower dose. I questioned the higher dose in the beginning, but he said this was the first and only treatment for bronchiectasis. I feel I was not having huge issues and should have started with the lower dosage. He is a highly recommended pulmonologist so I shall see if he honors my request.

@kwalkerz I hate to "bang this drum" again, but if your doctor, no matter how highly rated, will not have discussion with you fully explain their reasoning, and honor your reasonable requests, they are not a "Top Doctor" and you may want to consider another. Please tell them what you want and why and don't accept that Brinsupri is "the first and only treatment for bronchiectasis"

Brinsupri is the first (and currently only) PHARMACOLOGIC treatment, but there are MANY other treatments available including daily airway clearance, nebulizing saline solution, exercise, controlling other co-conditions like Asthma and COPD, even antibiotics and steroids as needed.

Do you have an appointment scheduled in the near future?

I did a quick inquiry via the internet to see how many patients have been prescribed Brinsupri and here are the results:

"As of the end of Q1 2026 (March 31, 2026), roughly 19,000–20,000 patients had started Brinsupri (brensocatib) treatment in the US since its commercial launch.

Brinsupri (brensocatib), from Insmed, is the first FDA-approved treatment (August 2025) for non-cystic fibrosis bronchiectasis (NCFB) in patients 12 years and older. It launched commercially in the US shortly after approval.

Key real-world prescription/uptake data from Insmed’s reports:By end of 2025 (primarily Q4 launch period): ~11,550 cumulative patients started on therapy (with ~9,000 new starts in Q4 alone). About 4,000 prescribers by year-end.

Q1 2026: ~7,800 new patient starts (some from a backlog of “ready and waiting” patients). Cumulative prescribers exceeded 5,000 (over 25% of US pulmonologists).

This brings the cumulative total to roughly 19,350+ patients who have been prescribed and started treatment by the end of Q1 2026. Insmed has not publicly released a more precise or updated cumulative figure beyond these launch metrics (they shift focus to revenue guidance once the launch matures).

investor.insmed.com"

That is a lot of patients! I am hoping most are getting benefits and if not the great thing about Brinsupri is the results are reversible once you stop taking it. No one should be taking it if they feel it isn't helping their symptoms or they are experiencing side effects. The whole point of the medication is to help Bronchiectasis patients with symptom management by decreasing lung inflammation that sets us up for those exacerbations. You still have to do airway clearance and take all our other medications to keep safe. It is a tool in the pulmonologist's toolbox.

So for those that are scared about the side effects or are experiencing side effects just like @sueinnm is saying we still have all our tried and true bronchiectasis management tools. Communication with our pulmonologists is key here.

In my case I was struggling every day with volumes of sputum, poor sleep, unexpected coughing jags and isolating myself from my normal activities over fear of either getting sick or public coughing spells. I attended webinars and read all I could on ways to help myself and made the changes when new ideas came to light. For me Brinsupri has been life changing and I hope this stays this way for a long time. I don't really know why I have responded and others have not. I told the Insmed support staff I am very willing to be a part of further studies to help others. I have a CT Scan coming up that will be very telling in turns of mucous load in my lungs.

Just like with so much of this disease there are gray areas and it can be so frustrating when things are not going well. I get it and I feel for every one of you as I read your situations. I just wanted to share my little ray of hope.

@dpaula Thank you for the update. I’ve just recently started with Birnsupri a few days ago.
I’m very excited but nervous also.

@ja24
I’m new to Brinsurpi , just started a few days ago. I’ve had
Bronchiectasis since early childhood. I was formally diagnosed at the age of 30. Was told my whole childhood I had chronic bronchitis. At 31 I had my first CT scan, which was then discovered most of the Bronchiectasis was localized in my lower left lobe. I had surgery that part of my lung was removed. The surgery was successful and helping sputum production. In a nutshell, I still have flareups and sickness is just the way of life so though I am new to this medication and I’m excited about it. I’m also very scared of side effects and cautious.
I am thankful to be able to read everyone’s stories. This is the first time I’ve actually feel like there’s some support with this condition.

@atkins10001 Welcome to Mayo Connect and our MAC & Bronchiectasis Support Group. Many of us suffered for years without an accurate diagnosis, so we get it!
I hope Brinsupri is helpful for you - please share your experience with us in the next few weeks/months.

Are you doing airway clearance as well?

Hi there, yes I definitely do airway clearance. Saline solution, NAC solution and occasionally albuterol as needed. The bronchiectasis has returned in the last few years and I have a lot of mucus plugging.. which now is very hard to get up and out. Now as I am older at 64 I’ve been living with bronchiectasis around 60 years. It’s very promising that there is a medication and a lot more studies going on which is very hopeful. I will definitely post how I’m doing how I’m feeling. I do appreciate this group and I’m glad that we’re all sharing experiences.