I did a quick inquiry via the internet to see how many patients have been prescribed Brinsupri and here are the results:

"As of the end of Q1 2026 (March 31, 2026), roughly 19,000–20,000 patients had started Brinsupri (brensocatib) treatment in the US since its commercial launch.

Brinsupri (brensocatib), from Insmed, is the first FDA-approved treatment (August 2025) for non-cystic fibrosis bronchiectasis (NCFB) in patients 12 years and older. It launched commercially in the US shortly after approval.

Key real-world prescription/uptake data from Insmed’s reports:By end of 2025 (primarily Q4 launch period): ~11,550 cumulative patients started on therapy (with ~9,000 new starts in Q4 alone). About 4,000 prescribers by year-end.

Q1 2026: ~7,800 new patient starts (some from a backlog of “ready and waiting” patients). Cumulative prescribers exceeded 5,000 (over 25% of US pulmonologists).

This brings the cumulative total to roughly 19,350+ patients who have been prescribed and started treatment by the end of Q1 2026. Insmed has not publicly released a more precise or updated cumulative figure beyond these launch metrics (they shift focus to revenue guidance once the launch matures).

investor.insmed.com"

That is a lot of patients! I am hoping most are getting benefits and if not the great thing about Brinsupri is the results are reversible once you stop taking it. No one should be taking it if they feel it isn't helping their symptoms or they are experiencing side effects. The whole point of the medication is to help Bronchiectasis patients with symptom management by decreasing lung inflammation that sets us up for those exacerbations. You still have to do airway clearance and take all our other medications to keep safe. It is a tool in the pulmonologist's toolbox.

So for those that are scared about the side effects or are experiencing side effects just like @sueinnm is saying we still have all our tried and true bronchiectasis management tools. Communication with our pulmonologists is key here.

In my case I was struggling every day with volumes of sputum, poor sleep, unexpected coughing jags and isolating myself from my normal activities over fear of either getting sick or public coughing spells. I attended webinars and read all I could on ways to help myself and made the changes when new ideas came to light. For me Brinsupri has been life changing and I hope this stays this way for a long time. I don't really know why I have responded and others have not. I told the Insmed support staff I am very willing to be a part of further studies to help others. I have a CT Scan coming up that will be very telling in turns of mucous load in my lungs.

Just like with so much of this disease there are gray areas and it can be so frustrating when things are not going well. I get it and I feel for every one of you as I read your situations. I just wanted to share my little ray of hope.