Brinsupri (aka Brensocatib)

Singulair worked great for me for about one week until I experienced heaviness in my body, as if it was hard to get out of a chair. Maybe that’s what depression feels like?It’s a rare side effect sadly, anyway, I had to discontinue.

Regarding inhaled steroids, I use Symbicort two puffs twice a day and when I get wheezy, I use an albuterol puffer. I take a lot of steps to avoid environmental triggers for asthma and allergies and NTM. HEPA Air Purifiers run in every room along with air conditioning. And a dehumidifier in the basement. Of course, twice a day airway clearance!

I wonder about the injectable biologics.

Close Follow up with pulmonary as I embark on brinsupri. Based on the webinar, I listened to yesterday if it’s going to work, I should notice symptom reduction within six weeks. I’m willing to take that risk.

I have listened to two webinars on Brinsupri so far. But it is still not clear to me what symptoms we might notice improvement in after some time. Do you know? It does not seem clear what the actual benefits are that we might actually notice or experience. The main thing I heard early on was reduced exacerbations.

My understanding is reduced respiratory symptoms, including cough, sputum and exacerbations.

Keep us posted on how you feel, as I'm sure you will. I was on Symbicort a few years ago and my dr thought I'd do better on Trelegy-then I got MABC. I have an appointment with him this month and revisiting IC's is on the top of the list-but then if I get approval from Dr Haas (NJH dr), I might try the singular again. I'll post the 2025 NJH NTM BE Conference after it gets sent to me-hopefully these Brinsupri questions get answered. I'll try anything to get my inflammation down.

@scoop it is a bit disconcerting to me too that the Brensocatib/Brinsupri studies were not more objective in their data collection. Did they have participants measure sputum, or did participants have cough apps to help quantify coughing episodes? These are our daily trials and tribulations. I was even hoping we would hear more from the early research participants. But so far I am not seeing resounding success stories. And the Q and A with Dr. Metersky even left me with more questions about the roll out of the medication to the community pulmonologists.

Reduced exacerbations is the goal of this drug. Continued airway clearance is crucial to this process though. So as I understand the mechanism of brinsupri, there is a reduction in production of the enzyme DPP1 produced by neutrophils which causes the inflammatory process - thus reduction in exacerbations. Staying well longer between infections is what we should notice.

Has anyone heard that you need a BMI of 18.5 to be prescribed Brinsupri? My pulmonolgist says my BMI is too low for him to prescribe it. (16.8)

I guess if one has chronic infection as opposed to "between infections" then one might expect feeling less exacerbated daily?

It would be very useful to know if this is true and why. Your pulmo is probably much more careful than mine is! Or more thorough. It is the first I have heard of it but maybe we can ask on the next webinar. Can you ask your pulmo where he or she heard that? Mine is 16.5.

Found this online and it makes sense so maybe your pulmo is mistaken?

BMI as a clinical trial criterion
It is common for clinical trials to use BMI to select a specific patient population, which can lead to confusion over whether it applies to a real-world prescription.
For example, one study for Brensocatib required participants to have a BMI between 18 and 35 kg/m².
The phase 3 ASPEN trial required participants to have a BMI of at least 18.5 kg/m².
These criteria are specific to the study and do not mean that a person with a BMI outside of this range cannot be prescribed the medication by their doctor.