Anyone partaking in this clinical trial for low dose Tam?

Posted by whitehairwisdom @whitehairwisdom, Jan 13 12:24pm

https://www.clinicaltrials.gov/study/NCT06671912
Is anyone part of this clinical trial which began in Feb 2025? Curious to know if you've had any side effects and what are they?

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Determining how well one’s body metabolizes Tamoxifen is crucial data for determining dosage.

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Is low-dose Tamoxifen considered to be 10 mg or 5 mg? Just curious. I currently take 10 mg. Started Jan 1st & doing ok but I feel a little tired & have some mild headaches. Hoping the side effects go away as my body adjusts.

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I started the discussion because my onco doc suggested that I would be a good candidate for the low Tam trial due to my type of BC cancer and I wanted to know how someone on this drug at the lower dose was tolerating it however, after signing up for the trial, I was not chosen for the group to take 5mg of Tamoxifen but chosen for the other group which is a normal dose of an AI. After reading through a lot of the comments here on this forum, I opted not to participate and dropped out of the trial. I was willing to try the 5mg of Tam but not a higher dose of another drug. I even asked my doc do I have to participate in the clinical trial to get 5mg of Tam and the answer was "YES", which I found concerning. What drove home my decision not to take any drugs at this time were 2 comments the doc said to me and those were "well, you also have to consider your quality of life in making a decision" and "the drugs are to reduce distant recurrence". "Distant" recurrence I wondered? I'm 68 years old. So if taking an AI is only reducing recurrence later in my life and at a very small percentage, I'd rather enjoy the time I have left and not have to constantly battle with side effects of the drug, even if they are mild. What is most frustrating to me about BC treatment is after all these years and tons of money thrown at research, this is the best you got for us??? I am on the prowl now to seek out a 2nd opinion for my treatment, if any, however, I am not holding my breath that much will change. I will continue to maintain a healthy diet, stay active and get plenty of sleep in hopes that my cancer doesn't return. That's the best choice I think I have made for myself right now going forward.

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@whitehairwisdom because the 5 mg is not available here in the US, many women take the 10 mg Tamixifen every other day. With or without telling their doctors, it seems. I see their comments online!

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