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Evusheld Update

Posted by joko @joko, Aug 11, 2022

Thanks everyone on here for info on Evusheld and sharing experiences with the AstraZeneca monoclonal antibodies injections. I was listed on the University of Wisconsin Transplant list lottery, but used the website https://covidsafe.fyi/evusheld/ to check on my county, Door, to see that we didn't have any doses. Contacted them and they ordered some. Yesterday I got the two injections and have had no reactions. Just to share with others who are wondering about Evusheld. About price. My Medicare Advantage insurer checked and it was $0.50 out of pocket. Probably because the Feds bought 1.7 million doses and must be subsidizing. Hope this is helpful.

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mjq | @mjq | Dec 7, 2022
In reply to @lizzy102 "I do not have a reference. I was told by the Evusheld Clinic at OHSU that..." + (show)
@lizzy102

I do not have a reference. I was told by the Evusheld Clinic at OHSU that CDC had just announced that Evusheld did not work against the new variants and so had been discontinued. They are no longer making appointments for Evusheld shots. CDC may not have updated their website yet?

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Nothing on CDC web site indicates Evusheld has been discontinued.

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hello1234 | @hello1234 | Dec 7, 2022

As of the week ending November 5, more than half of new Covid-19 infections were caused by subvariants that Evusheld does not neutralize.
There are also concerns that the bebtelovimab monoclonal antibodies infusion will not work against the new variants. But I saw that the hospitals are being told to keep their unexpired inventory in case a new future variant coming down the road is neutralized by using it.
(It's important to keep options on the shelf when there are no replacement treatments yet.)
I don't know that the FDA will "discontinue" these drugs, but the providers may discontinue using it so patients don't get a false sense of protection.

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1 reply
jackiez | @jackiez | Dec 7, 2022

I have my periodic checkup appt at Mayo next week. I had been scheduled for an Evushield injection - my second round. However it has been removed from my schedule. Seems to confirm what’s being communicated on here too.

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mollyv | @mollyv | Dec 7, 2022
In reply to @lizzy102 "As of Friday, 2 December, Evusheld has been discontinued. CDC says it does not work against..." + (show)
@lizzy102

As of Friday, 2 December, Evusheld has been discontinued. CDC says it does not work against the newer variants. Heard it from the scheduler for Evusheld shots.

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@lizzy102 that would explain why I got Covid one month after my Evusheld treatment!! 😂

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1 reply
Mentor
Ginger, Volunteer Mentor | @gingerw | Dec 7, 2022
In reply to @hello1234 "As of the week ending November 5, more than half of new Covid-19 infections were caused..." + (show)
@hello1234

As of the week ending November 5, more than half of new Covid-19 infections were caused by subvariants that Evusheld does not neutralize.
There are also concerns that the bebtelovimab monoclonal antibodies infusion will not work against the new variants. But I saw that the hospitals are being told to keep their unexpired inventory in case a new future variant coming down the road is neutralized by using it.
(It's important to keep options on the shelf when there are no replacement treatments yet.)
I don't know that the FDA will "discontinue" these drugs, but the providers may discontinue using it so patients don't get a false sense of protection.

Jump to this post

@hello1234 Last week at my monthly oncologist appointment, we talked about Evusheld. Since I had my second dose in August, we will look at what is going on come February. I have had the bivalent shot also, plus a total of 4 Pfizer vaccines.

It certainly appears that protecting ourselves will be a multi-pronged approach, doesn't it? Personal protection in the form of masks, hand washing, social distancing. Careful monitoring of local conditions including flu and RSV. Constant vigilance from each of us in our own particular situations, to keep us as healthy as possible. "sigh" Never a dull moment...
Ginger

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joko | @joko | Dec 7, 2022
In reply to @l0lag0lag0b3 "https://www.fda.gov/drugs/drug-safety-and-availability/fda-releases-important-information-about-risk-covid-19-due-certain-variants-not-neutralized-evusheld" + (show)

"FDA continues to recommend Evusheld as an appropriate option for PrEP to prevent COVID-19, in combination with other preventative measures like getting vaccinated and boosted as recommended, as Evusheld still offers protection against many of the currently circulating variants and may offer protection against future variants."

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1 reply
hello1234 | @hello1234 | Dec 7, 2022
In reply to @joko ""FDA continues to recommend Evusheld as an appropriate option for PrEP to prevent COVID-19, in combination..." + (show)
@joko

"FDA continues to recommend Evusheld as an appropriate option for PrEP to prevent COVID-19, in combination with other preventative measures like getting vaccinated and boosted as recommended, as Evusheld still offers protection against many of the currently circulating variants and may offer protection against future variants."

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Thank you @joko 😊
I am curious what the different providers are going to do with this new FDA information. . I know the usual school of thought is it's better to have some protection than no protection. So even if Evusheld gets down to 25% effective, it's still better than 0% coverage against all the variants out there. Has anyone heard if Mayo is proceeding with Evusheld appointments?

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2 replies
Mentor
Cheryl, Volunteer Mentor | @cehunt57 | Dec 7, 2022

I’m post transplant and immune suppressed. My local provider and the team at Mayo both recommended Evusheld for me. This year I’ve had 2 doses so far (1 every 6 months). After I had my last dose they said “we’ll see you in 6 months”. I was told “it can’t hurt and might help”.

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