Just approved: Evusheld for the pre-exposure prevention of COVID-19

Posted by lizzy102 @lizzy102, Dec 10, 2021

Does anyone have any more information on this just-approved by the FDA treatment for immunocompromised people? From what I am reading, it seems very exciting. Boy, what I wouldn’t give for a bit of protection from the scourge virus!

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In reply to @marilynredder2367 "Maybe." + (show)
@marilynredder2367

Did you have adverse reactions to the COVID vaccines?

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Hi @beegie 😊
I am a kidney transplant patient on immune suppression. I had all the covid vaccines and boosters and received ZERO antibodies from all the vaccine shots. Then, I received Evusheld and tested >2500 antibodies (of course Evusheld is two shots filled with antibodies so that makes sense!).
I had no adverse reactions and I was very happy to receive a shot of insurance against covid.
Evusheld has a 77% effectiveness so remember to continue to mask indoors, social distancing, avoid crowds, wash hands, even after Evusheld. But I am hopeful that it gives us some protection against a bad result from covid.
That said, everyone should discuss this with their doctors since questions about possible rejection, neuropathy flare up, etc have been discussed in this thread as possible outcomes. Like every medical decision, we have to look at the percentage chance of a bad outcome to us against the possible benefits. It's difficult when a new infection and new treatments are introduced to the market because there is limited data to review about each possible circumstance.

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@beegie

Did you have adverse reactions to the COVID vaccines?

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No not the vaccines or boosters.

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@pacer3702

I haven't gotten Evusheld. My autoimmune issue coincided with my neurological damage and symptoms after the Pfizer vaccine. When my symptoms peaked, my ANA titer peaked. I also have Sjögren’s B autoantibody, but don't have Sjögren’s. Like most vaccine-injured people, my autoimmune profile doesn't fit into the available autoimmune diagnoses. That's likely because a toxic autoimmune reaction to the spike protein encoded by the vaccines has not happened before; this is new technology. The patients with neurological injuries in the Neuro V Long-Haulers Facebook group don't know what to do about Evusheld. I searched the posts last night and there were no reports of harm, but only two reports of using Evusheld, and those were initially positive experiences. I'm being cautious because Evusheld is another emergency use authorization. As another Mayo Connect patient indicated, you can read the Fact Sheet here. I'm concerned about the repeated emphasis in the document that Evusheld is unapproved by the FDA. https://www.fda.gov/drugs/drug-safety-and-availability/fda-authorizes-revisions-evusheld-dosing

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I am in the same position as you with neurological problems as result of Covid vaccine. I am afraid to get Evusheld because I see that it is mostly used on people who don’t make antibodies. Are u continuing to say no to Evusheld injection ?

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@beegie

I am in the same position as you with neurological problems as result of Covid vaccine. I am afraid to get Evusheld because I see that it is mostly used on people who don’t make antibodies. Are u continuing to say no to Evusheld injection ?

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I'm continuing to avoid Evusheld until there is more evidence that it's safe for people with neurological adverse effects from the Covid vaccines. One patient in the Neuro V Long-Haulers Facebook group posted that her doctor said no to Evusheld now but yes to Paxlovid in the event she gets Covid. That's my plan for now. Given the evidence that both Covid Long-Haulers and vaccine Long-Haulers are suffering from toxic effects of the spike protein, an antiviral drug seems to make sense (less virus = less spike protein). Despite the rebound effect with Paxlovid, most patients in the Facebook group seem to be helped by Paxlovid when they get Covid. Honestly, however, given my horrible experience with the Pfizer vaccine, I hate that I'm now in position to consider another of their Emergency Use Authorization products (Paxlovid).

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@missmissyb

Thank you for responding. Yes the neurologist thought it might be a better option than more mrna doses and ordered it (up to me).. I would also want to get the antiviral.. I am glad for you and anyone that could tolerate and then benefit. You dont have autoimmune neuro disease right? Ive only see a few people on here with autoimmune neuro disease, people like me who have severe “take downs” to vaccine and virus on here. Looking to discuss that specifically. Concerned that I could potentially flare worse and linger to Evusheld. Found case study of person who previously had Guianne-Barre response to mrna (simmilar to my responses) but this person did ok with the Evusheld so that was reassuring along with me having done mostly ok with ivig for some years.

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I have the same fear of taking evusheld. My reactions start a few days to a week after I get the COVID vaccine. They are neurological and can last a month or more. I am fearful that my body will flare with neuropathy and muscle weakness from the Evusheld antibodies….I am still on the fence about taking it. I hope to hear from people that have had reactions to Covid Vaccines and are taking Evusheld.

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I have a friend who has had two doses and no side effects beyond a little injection site soreness. My husband is a two time stem cell transplant recipient. He is getting his first in the next week or so since he is going back on dual chemo again.
Anybody else take this without incident?

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@athenalee

@pacer3702, I have autoimmune disease caused peripheral neuropathy, which increased after receiving the Pfizer vaccinations. Unfortunately, I caught Covid last month. I’m a liver transplant recipient, as such I was becoming quite ill. I was fortunate to receive monoclonal antibody treatment. I had a more severe reaction to the treatment however, including increased numbness and pain in my feet and legs, and new numbness in my face.

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Your reaction was to the Evusheld injections? Would u recommend the Evusheld?

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@auntieoakley

I have a friend who has had two doses and no side effects beyond a little injection site soreness. My husband is a two time stem cell transplant recipient. He is getting his first in the next week or so since he is going back on dual chemo again.
Anybody else take this without incident?

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@auntieoakley I had my first dose in February, but it was a half dose. They hadn't yet given the amount to be used, and I was the first one at the cancer center to get a dose. On 1 Sept I will get my second dose, and it will be the full dose. I had no reaction from the first one, just a bit of a sore butt cheek on one side!
Ginger

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@gingerw

@auntieoakley I had my first dose in February, but it was a half dose. They hadn't yet given the amount to be used, and I was the first one at the cancer center to get a dose. On 1 Sept I will get my second dose, and it will be the full dose. I had no reaction from the first one, just a bit of a sore butt cheek on one side!
Ginger

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Our most amazing doctor wants to give it to My Mister. In addition to every available dose of vaccine. Yep, we are in.

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