Anyone have nausea with Trintellix?

I used to take antidepressants on and off. I’ve just been on Wellbutrin for awhile but it hasn’t been helping me since I’ve had family members pass away.

I just tried taking this one today and pretty quickly started feeling unwell. Within 30 minutes I had vomited several times. I never vomited with any of my pregnancies either.

Going to try half a pill in the morning with breakfast tomorrow, but I’m wary to say the least.

I just started taking trintellix a few days ago (5mg) and I’ve puked and felt the horrible nausea which lasts for hours & hours. But trintellix has helped take the edge off my horrible thoughts and feelings of dread and I haven’t had relief like this in months so the decision for me to stay on it or stop is hard. I wondered if I take it when I go to bed if it will be okay by the time I wake up. So I might try that tonight and see but I also take quite a few other meds, so idk if it will affect them or not?

Yes, it one of the side effects.

Although Trintellix is suppossed to be "tolerated well", I was sick the entire time I was on it. I had bad nausea, vomitting and diarrhea the entire time I was on it. I started with 5 mgs. with the plan to increase it gradually as I developed tolerance to any side effects. I gradually increased the dose from 5mg. to 7.5mg and was so sick that I couldn't go above that dose. I found OTC meds helped decrease the S.E., but I shouldn't have to take more pill inorder to tolerate Trintellix . I was fine with taking another med short term until I develooped tolerance to the side effects, but after 5 mg that didn't happen-no tolerance. It was finally stopped. I hope people on it do better than I did.

I'm really hoping this conversation is still going. I took Trintellix in 2020 and got extremely sick within the first couple of weeks. Vomiting, nausea, stomach pain, stomach bloating, exhaustion, weight loss. They did a battery of tests because no one could explain why I was so sick. I only took this drug for THREE MONTHS and I was diagnosed with a non curable disease called Gastroperesis that feels like I have the flu every day. It's so severe that my life basically stopped in 2020. Has anyone had a slow motility or Gastroperesis diagnosis from this drug??

Good morning. I have been on Trintelix about 5 months. Started with 10mg for about 6 weeks. During the 1st couple of weeks I vomited twice. No nausea, just a feeling in my throat that caused me to vomit, only bile, no stomach contents. We increased to 20mg after about 7 weeks. A couple of months ago the vomiting started again, 2-3 times a week. Again, no associated nausea, just a feeling in my throat that causes me to vomit bile. It's brief, but the feeling in my throat is present most of the time. Of note, I have been under considerable pressure at work for several months so it is possible the vomiting might be a result of stress, although I have never been a stress vomiter.

I am wondering if anyone else has had a similar experience, and if ultimately the vomiting subsided. I have experienced improvement with the use of Trintelix (I had previously been on Viibryd for roughly 10 years but it was no longer doing the job).

Hi there
I’ve just started taking it (2nd day) and on 5mg for first week before increasing to 10mg. I’ve never had nausea from any of my other medications but my Dr did warn me re this one, and sure enough I’m feeling it for last 2 hours since taking my dose. I know everyone is saying it can last for a few days etc but is it constant or just a few hours in the morning after taking it?

Nausea was one of side effects for me which lasted all day.

I just started Trintellix three days ago and each day the nausea has gotten worse. I have IBS and a very sensitive stomach. I asked my doctor to prescribe me an anti nausea medication today because I know if it continues to make me this sick I’ll quit taking it. She didn’t call anything in just said to start taking it at night instead of the morning. Any helpful advice anyone has would be greatly appreciated because being that nauseous is one of my biggest weaknesses. I just can’t tolerate it. Thank you.

I'm also on Trintellix, been on it for over a year now and have had cycilic vomitting with this medication the entire time...its not every day but when it does happen it is horrible nausea and extremely violent stomach convulsions and vomitting. My prescriber doesn't think its Trintellix because I've been on it a year and the vomitting is sporadic. Drug works well but my quality of life I may as well be severely depressed and my depression has worsened because no doctors can help me...I've had every single tes t all bloodwork, hormones, even upper endoscopy are normal...saw a rheumatologist and was tested or all autoimmune disease and absolutely nothing physically wrong with me. I suspect this has something to do with sodium channels and serotonin which I know a lot of serotonin is produced in the stomach. This med is not worth the horrible nausea and in fact I feel worse than when I started Trintellix. I told my doctor that I'm quitting it immediately and won't be taking it again. I feel like I've been ignored and poisoned and spent the last year of my life afraid to leave my home and vomitting everywhere, when I barfed all over myself at the gym last week that was it...done with this and would never recommend Trintellix to anyone that asks my opinion.