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Anyone have nausea or other GI issues with Trintellix?

Posted by nansmith @nansmith, Nov 1, 2017

Anyone have nausea with Trintellix 5mg? How long did it last? Been taking for almost 6 weeks and still have some nausea...will it get worse if I titrate to 10mg? Thanks.

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rightgirl | @rightgirl | May 6, 2021
In reply to @sharielliker "I've been taking trintellex for about 22 days now and all of a sudden have terrible..." + (show)
Profile picture for sharielliker @sharielliker

I've been taking trintellex for about 22 days now and all of a sudden have terrible nausea. Has anyone else experienced this delayed reaction?

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I had severe non stop nausea on Trintellix 10 mg for 2 months. It even caused a trip to the emergency room ( I couldn’t figure out what was causing the nausea since I tolerate most drugs well). When my dr and I finally figured out what was causing it, I switched back to Lexepro and I’ve been fine.

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sunshinestacy | @sunshinestacy | May 14, 2021

I had nausea so bad I had to discontinue after just a few weeks

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marjou | @marjou | May 28, 2021

I too have had nausea with this even at low dosage of 2.5 mg. Had to stop taking it.

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frankiep | @frankiep | Oct 20, 2021

Hi Friends, I’m brand new to this forum and just over two weeks into Trintellix. I was on 5mg for one week and my doctor upped me to 10mg for the second week. Nausea has followed me from the start and constipation/stomach cramps have now been added to the mix. My question is, how long did it take to feel positive effects of the medication and whether those benefits now outweigh the side effects? Also have the negative side effects continued for much longer than 2-3 weeks?
Thank you!
Frankiep

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tink1 | @tink1 | Dec 26, 2021
In reply to @heidi1346 "I am extremely nauscious from trintellix and have an upset stomach. I believe the Nausia goes..." + (show)
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I am extremely nauscious from trintellix and have an upset stomach. I believe the Nausia goes away but does the upset stomach go away

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I have now been on Trintellix for four weeks and the nausea is not going away. I have it every morning and due to working from home and off work for the holidays I can rest it off. However I cannot continue to function like this daily. I am going to discuss alternate choices or go back to Celexa when I see my doctor in New Year

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Colleen Young, Connect Director | @colleenyoung | Dec 27, 2021
In reply to @tink1 "I have now been on Trintellix for four weeks and the nausea is not going away...." + (show)
Profile picture for tink1 @tink1

I have now been on Trintellix for four weeks and the nausea is not going away. I have it every morning and due to working from home and off work for the holidays I can rest it off. However I cannot continue to function like this daily. I am going to discuss alternate choices or go back to Celexa when I see my doctor in New Year

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Hi Tink,
Like you, several members have experienced nausea with Trintellix. I'm tagging @frankiep @heidi1346 @kelster69 @marjou @sls87113 @sunshinestacy @rightgirl so they can share their experiences and solutions with you.

Tink, I'm glad you have an appointment with your doctor in the new year to discuss options. May I ask why you and your provider chose to switch meds from Celexa to Trintellix?

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tink1 | @tink1 | Jan 4, 2022
In reply to @depressionsurvivor "I struggled with intermittent nausea for quite some time with Trintellix (15 mg). I would recommend..." + (show)
Profile picture for depressionsurvivor @depressionsurvivor

I struggled with intermittent nausea for quite some time with Trintellix (15 mg). I would recommend "playing around" with the dosing (i.e. dosing 1/2 in the morning, 1/2 at night) with your doctor's approval to try to find an acceptable dosage regimen without the nausea interplay. This medication (Trintellix) has REALLY worked wonders for me, so I am thankful for taking the time to "work through" this side effect. It does also seem to get better/less frequent with time.

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I tried this over the holidays and it really helped. Half after breakfast and half after dinner

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tink1 | @tink1 | Jan 4, 2022
In reply to @heidi1346 "I had to stop the Trintellix. The constipation was worse than the nausea. Anyone have severe..." + (show)
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I had to stop the Trintellix. The constipation was worse than the nausea. Anyone have severe constipation

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I have been on just over a month and yes constipation is an issue. Have been trying fibre powder in my drinks.

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marjou | @marjou | Jan 4, 2022
In reply to @tink1 "I have been on just over a month and yes constipation is an issue. Have been..." + (show)
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I have been on just over a month and yes constipation is an issue. Have been trying fibre powder in my drinks.

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Yes nausea and stomach issues which is common side effect on this medication.

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rightgirl | @rightgirl | Jan 6, 2022
In reply to @colleenyoung "Hi Tink, Like you, several members have experienced nausea with Trintellix. I'm tagging @frankiep @heidi1346 @kelster69..." + (show)
Profile picture for Colleen Young, Connect Director @colleenyoung

Hi Tink,
Like you, several members have experienced nausea with Trintellix. I'm tagging @frankiep @heidi1346 @kelster69 @marjou @sls87113 @sunshinestacy @rightgirl so they can share their experiences and solutions with you.

Tink, I'm glad you have an appointment with your doctor in the new year to discuss options. May I ask why you and your provider chose to switch meds from Celexa to Trintellix?

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My nausea while on Trintellix became unbearable. I switched back to Lexepro and it disappeared immediately. Lexepro works well for me. Give it a try.

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