Anyone have nausea with Trintellix?

Posted by nansmith @nansmith, Nov 1, 2017

Anyone have nausea with Trintellix 5mg? How long did it last? Been taking for almost 6 weeks and still have some nausea…will it get worse if I titrate to 10mg? Thanks.

@heidi1346

Thank you. Did you get cdiff from trintellix

Jump to this post

Hello No I got C.Diff from four sulphur antibiotics in 4 months for UTIs and then 2 more from urologist (very nice doctor)..even that antibiotic had a warning about it possibly causing C.Diff and I can send a photo….. but already had IBSD. It wasnt the diarrhea as one might get from a bad meal or such, but was very bad and as I mentioned, the Imodium I took before to semi control it could not be taken while on antibiotic – even when I had to take over 140 Vancomyin antibiotics for the C.Diff… long story short… it was life changing and I can describe it another time: I certainly dont want to discourage any taking medication because diarrhea is a side effect: but right on the information about the drug you are asking about it says to advise your Dr. if you get diarrhea… then you and your Doctor can decide. It's just that I find there is diarrhea and then there is DIARRHEA…. and unless you have been through it as people have, or suffer from it with IBS-D and other bowel issues, it can be a life changer and has stopped me from travelling or even visiting people etc (pre covid). Hopefully you can find a solution and I wish you the very best, as I too suffer from depression and anxiety, J.S.

REPLY
@heidi1346

I took two duculox the night before so maybe that is why the diarrhea is so bad. 5 mg

Jump to this post

@heidi1346 Heidi… did you take DucolAx ? Yes that's a laxative .. I have taken it before having Colonoscopy! If you only had diarrhea after taking this, then question might be, do you get diarrhea after taking Trintelix not just when taking Ducolax????? Just curious, J.

REPLY
@colleenyoung

Hi @heidi1346 and welcome to Mayo Clinic Connect. It sounds like Trintellix (vortioxetine) is causing several digestive related issues for you, including nausea, upset stomach and severe diarrhea. Nausea is the most common side effect of this drug. I'd like to bring @rossjt @marjou @trip17 @elwooodsdad @petangelkat1 @jeanmnyc @marazion @alamogal635 and @kelster69 into this discussion so they can share their experiences with you.

While we wait for others to join in the discussion, you may also wish to see this discussion thread:
– Switching to Trintellix or Low Dose Naltrexone (LDN) https://connect.mayoclinic.org/discussion/trintillix/

Heidi, have you discussed the side effects you're experiencing with your doctor? How long have you been taking Trintellix? What dosage?

Jump to this post

I will be discussing with doctor tomorrow. 5mg for 4 days and like I said I took duculox the night before. Hope do i know when a discussion is in progress

REPLY
@lacy2

@heidi1346 Heidi… did you take DucolAx ? Yes that's a laxative .. I have taken it before having Colonoscopy! If you only had diarrhea after taking this, then question might be, do you get diarrhea after taking Trintelix not just when taking Ducolax????? Just curious, J.

Jump to this post

Yes I got severe dishreah after the duculox. Maybe the diarrhea would not have been so bad if I didn't take the duculox

REPLY

Has anyone gained weight on Trintellix

REPLY
@colleenyoung

Hi @heidi1346 and welcome to Mayo Clinic Connect. It sounds like Trintellix (vortioxetine) is causing several digestive related issues for you, including nausea, upset stomach and severe diarrhea. Nausea is the most common side effect of this drug. I'd like to bring @rossjt @marjou @trip17 @elwooodsdad @petangelkat1 @jeanmnyc @marazion @alamogal635 and @kelster69 into this discussion so they can share their experiences with you.

While we wait for others to join in the discussion, you may also wish to see this discussion thread:
– Switching to Trintellix or Low Dose Naltrexone (LDN) https://connect.mayoclinic.org/discussion/trintillix/

Heidi, have you discussed the side effects you're experiencing with your doctor? How long have you been taking Trintellix? What dosage?

Jump to this post

I talk to my doctor tomorrow. I have been on 5 mg for four days. Maybe if I did not take the Ducolox, the diahreah would not have been so bad. Is weight gain a side effect. Hearing different things

REPLY
@kelster69

@heidi1346 , I was on Trintillex for about 6 weeks last summer. I did have nausea when I started taking it, and my doctor prescribed an anti-nausea I could take with it. That said, I started to tolerate the drug better after a couple of weeks. No diarrhea, but if the Trintillex works for your depression, maybe you could talk to your doctor about taking something to stop your diarrhea. I've learned that if you find something that helps you, it's worth putting up with the side effects (to a reasonable extent). Depression is hell and anything that you can arm yourself with to fight it is worth trying. All the best to you.

Jump to this post

Thank you

REPLY
@heidi1346

I am extremely nauscious from trintellix and have an upset stomach. I believe the Nausia goes away but does the upset stomach go away

Jump to this post

I have the nausea and upset stomach at 2.5 mg.

REPLY

I had to stop the Trintellix. The constipation was worse than the nausea. Anyone have severe constipation

REPLY

I have a friend who has had amazing results with Trintellix for her depression. I have been on Celexa for many years. I can only take 10 mg because I have restless leg syndrome which I control by taking Gabapentin at night. Does anyone know how Trintellix affects restless leg syndrome.

REPLY
@sls87113

I have a friend who has had amazing results with Trintellix for her depression. I have been on Celexa for many years. I can only take 10 mg because I have restless leg syndrome which I control by taking Gabapentin at night. Does anyone know how Trintellix affects restless leg syndrome.

Jump to this post

@sls87113 Welcome to Mayo Clinic Connect, a place to give support. You have support and information to share with peers.

You have a friend that has had amazing results from Trintellix for her depression.

You have taken Cenexa for some time. Is this to treat depression? You also take Gabapentin for restless leg syndrome. You are wondering if Trintellix affects restless leg syndrome.

May I ask how Celexa has been working for you?

REPLY
@erikas

@sls87113 Welcome to Mayo Clinic Connect, a place to give support. You have support and information to share with peers.

You have a friend that has had amazing results from Trintellix for her depression.

You have taken Cenexa for some time. Is this to treat depression? You also take Gabapentin for restless leg syndrome. You are wondering if Trintellix affects restless leg syndrome.

May I ask how Celexa has been working for you?

Jump to this post

Hi Erika, I have been taking 10 mg of Celexa plus 1 mg of Clonazepam to help with anxiety since 2010. I could never take more than 10 mg because it exacerbated my restless leg syndrome which is very severe. I suffered from spinal stenosis also causing me great pain in my neck area and was given Gabapentin 900 mg per day. I had an ablation procedure finally which eliminated my pain but I continue to take the Gabapentin once I realized it worked for restless leg syndrome and my severe symptoms return if I stop it. This pandemic has caused my chronic depression to ramp up. I tried to go up to 20 mg of Celexa but my legs flared up. So I cut back to 15 mg which I can tolerate and has helped but I battle keeping the sadness at bay. That is why my friend with chronic depression recommended I try Trintellix also. I am very reluctant to tamper with my Celexa because I have suffered so much my whole life with restless legs. My doctor is willing to work with me on the antidepressant but will not increase my Gabapentin which I don’t want to do either. So that prompted my question regarding Trintellix and restless legs. Thanks so much for your inquiry.

REPLY
Please sign in or register to post a reply.
  Request Appointment