Hyperhomocysteinemia with MTHFR C677T mutations. Does anyone have this

The doctor is attempting to find more information and is reluctant to recommend the vaccine without more information. It appears there is limited information. The teaching university where records were sent has yet to respond after several phone calls. It appears there is limited and confusing research on this gene.
Other types of vaccinations have not caused major problems. Sensitivity to metals, medications, and foods have been issues.

I'm very glad that he is being cautious. Keep being very protective of your own safety and health

Has anyone with the double mthfr variant received the COVID 19 vaccine?

My wife has experienced neuropathic pain in her legs and feet for years. Our primary care md at UAB’s Kirklin Clinic in Birmingham tested her vitamin B6 level and it’s extremely high at 174. She takes no supplements and as a pharmacist I started researching this and found that the C677T & A12980 mutations of the MTHFR gene could be the source of this elevated B6 as these mutations of these genes prevent the conversion of the synthetic b6 to p-5-p form of b6 that is used by our cells. In fact I find literature indicating that she could literally be low in the needed b6form used by her cells and could need supplements of p-5-p form of B6. In summary these mutations and B6 issues could be source of her peripheral neurophy pain in her lowe legs and feet. We cannot find Any md’s at UAB that know how to treat this condition and I’m reaching out to see if anyone else has dealt with this issue and if help is available at Mayo ofr John’s Hopkins to help us deal with this problem with clinical treatment.

Yes, I have. For me personally there were no issues with it at all, except for the fact that I had a bit of a tender arm the first couple of days with the first dose. Didn’t notice anything with the second dose. However that’s just my own experience and I am not a doctor, pharmacist or geneticist, and can’t give advice

I will start out with the fact that I am not a doctor or a pharmacist or a geneticist and am not offering advice. I am a person with almost identical methylation SNPs, each of which reduce the body‘s ability to utilize folic acid. Mine were shown to be in the yellow zone on testing, not red. The data I provide comes from a paper written by PureGenomics in Ontario Canada. My diagnosis eventually came through a most knowledgable ND, just 4 years ago. At the same time, I am all for doctors and have been a patient of Mayo for 60 years. I wonder if Mayo has NDs on staff who could guide you moving forward, I’m sure there are geneticists available to answer your questions? Wishing the best to you and your wife!

Thank you Allen. Any chance you would feel comfortable sharing your email with me, or your wife’s email perhaps, so we can discuss offsite? I feel this is getting more personal than some others would require, if you wouldn’t mind? Thank you, Dianne

Thank you so much for your reply. Which vaccine did you receive?