Reclast infusion side effects?

Posted by ladybugnc @ladybugnc, May 26, 2025

I had the Reclast infusion 5 months ago in my left arm. I have started having pain in that arm now, with loss of strength. Has this happened to anyone else?

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Profile picture for harborside24 @harborside24

@lwidstrand I have had two Reclast infusions (2025 and 2026) and noticed weight gain with this second one in early August. I was on a steroid back in May for severe lower back pain, so I guess it's possible it could actually be from that...or perhaps a combination of the two. I did gain a few pounds on Fosamax when I was on it years ago, but eventually it leveled off a bit. As soon as I stopped Fosamax, the weight came right off. It's mostly in my abdominal area, which is where it was while on Fosamax. I cannot get the scale to move no matter what I do. My endo had never heard of that, but he said if patients don't mention it to him, of course he wouldn't know. It's very frustrating, especially knowing that I have one more infusion to go in 2027.

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@harborside24 honestly, if your only “negative” symptoms from Reclast infusion is a few pounds weight gain, that is really not a bad thing. I do know weight to some people is very important and I am not attempting to make fun of a few pounds! The potential side effects from Reclast is far worse than weight gain and I know from experience. Hopefully your weight will level out in time or go back to your desired weight! My endocrinologist, neurologist and rheumatologist all says none of my symptoms are related to the infusion, yet I experienced none prior to the infusion!

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Profile picture for dannyandebbie @dannyandebbie

@harborside24 honestly, if your only “negative” symptoms from Reclast infusion is a few pounds weight gain, that is really not a bad thing. I do know weight to some people is very important and I am not attempting to make fun of a few pounds! The potential side effects from Reclast is far worse than weight gain and I know from experience. Hopefully your weight will level out in time or go back to your desired weight! My endocrinologist, neurologist and rheumatologist all says none of my symptoms are related to the infusion, yet I experienced none prior to the infusion!

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@dannyandebbie Yes I still have crippling back pain more than three months after my Reclast infusion.

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Profile picture for weissl @weissl

@dannyandebbie Yes I still have crippling back pain more than three months after my Reclast infusion.

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@weissl
How will the effectiveness of reclast be measured? Bone markers? Wait for a dexa?

What does "crippling" mean for you?

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Profile picture for ladybugnc @ladybugnc

I have also gained 10 lbs and I am trying to get back to my usual weight and it is not easy. I am now 145 lbs 5’5” and have been 135 for a very very long time. I am eating less, drinking more water and exercise and walking more.

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@ladybugnc I didn’t even think about that as my reason, but it totally lines up. I’ve def put on weight
🙁

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Profile picture for ladybugnc @ladybugnc

I have also gained 10 lbs and I am trying to get back to my usual weight and it is not easy. I am now 145 lbs 5’5” and have been 135 for a very very long time. I am eating less, drinking more water and exercise and walking more.

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@ladybugnc Exact same I’ve maintained 135ish for years and now 143-145
The stiff neck and headaches are frustrating. I hope it all fades with time, it’s been 5 months.

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My first Reclast infusion was a piece of cake. My recent one this year (2nd one) caused 6 weeks of left hip pain as well as lower back pain. Very stiff as well. FINALLY 2 days ago the pain subsided. I don't think I'll go for #3 next year.

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Profile picture for jar124 @jar124

My first Reclast infusion was a piece of cake. My recent one this year (2nd one) caused 6 weeks of left hip pain as well as lower back pain. Very stiff as well. FINALLY 2 days ago the pain subsided. I don't think I'll go for #3 next year.

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@jar124

Will you be taking a drug holiday? I forget what drugs or at least the last bone med before reclast.

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Profile picture for ilm12345 @ilm12345

@ladybugnc Exact same I’ve maintained 135ish for years and now 143-145
The stiff neck and headaches are frustrating. I hope it all fades with time, it’s been 5 months.

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@ilm12345

My same exact weight. Lol.
Do you live in Wilmington NC? I see the ilm.

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Profile picture for jar124 @jar124

My first Reclast infusion was a piece of cake. My recent one this year (2nd one) caused 6 weeks of left hip pain as well as lower back pain. Very stiff as well. FINALLY 2 days ago the pain subsided. I don't think I'll go for #3 next year.

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@jar124, the doctor that ran the clinical trials almost never gives the 2nd year Reclast injection because the first is often enough for two years. But he runs bone markers to be certain. Do you think the relief was gradual or rather sudden. Sorry you've suffered.

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Profile picture for harborside24 @harborside24

@lwidstrand I have had two Reclast infusions (2025 and 2026) and noticed weight gain with this second one in early August. I was on a steroid back in May for severe lower back pain, so I guess it's possible it could actually be from that...or perhaps a combination of the two. I did gain a few pounds on Fosamax when I was on it years ago, but eventually it leveled off a bit. As soon as I stopped Fosamax, the weight came right off. It's mostly in my abdominal area, which is where it was while on Fosamax. I cannot get the scale to move no matter what I do. My endo had never heard of that, but he said if patients don't mention it to him, of course he wouldn't know. It's very frustrating, especially knowing that I have one more infusion to go in 2027.

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@harborside24 I am in my 18th month after having Reclast. My weight is still high. 15 pounds overweight. Nothing has changed. I have fat everywhere. Places on my body that have never been fat. I thought by now I would see some improvement.

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