@lwidstrand How many infusions have you had? When I was on Fosamax, I was stunned at how fast it came on. But it came off equally fast. Reclast is a whole other animal! I have one more infusion to go next year, but then it will be a year after that until it's out of my system, I think. Not looking forward to basically two more years of watching the scale. And it's not the only osteoporosis med that I've heard causes weight gain. There must be something about what's in these meds that causes this problem. Hang in there, and I will do the same. I do know that the dexamethasone that I was on in May totally upsets your metabolism. I have read that it can take 6-12 months for your metabolism to regulate. What?!!!