Vit D-3 and K-2

I take Vit D3. I just heard my SIL say that she also takes K2 with it. She was told to do this by a Nutritional/Health food store owner she’s been working with. I intend to explore it myself.

D3 and K2 work together. As far as I know, no adverse effects.

K2 helps the blood to clot. It should be avoided if on warfarin and should be taken under the guidance of your cardiologist, especially if you are at risk for stroke. Supplements can be inconsistent so try to find one that is 3rd party tested. Most of us get enough K2 by eating leafy green vegetables. Supplements can be dangerous at high doses.

According to AI - "Most supporting data comes from small or observational studies. Large randomized controlled trials—the gold standard in medicine—lack definitive proof that D3 and K2 reduce vascular calcification or heart disease"

I take D3 and K2 for bone health, not for heart health.

Eat like it is 1926 and avoid the hype of supplements. Use them sparingly.

@fred1
Large controlled trials require large funding and most supplements are not large money makers like new prescription drugs. Established prescription drugs that are being used off label are also not usually the subject of large clinical trials. The bottom line is, if you're being monitored by a doctor for any condition/concern then it's best to follow their advice or find a new doctor that you trust. I take D3 on the advice/request of my cardiologist based on my semiannual blood work that he orders. I don't take K2 because he doesn't recommend it. I'm taking eliquis due to my stroke risk with AFib and I eat enough healthy greens. On a side note, AI is not 100% accurate. You can debate an AI app and win.

@mikebiker my research indicates that D3 and K2 work well together for bones…be careful of how much supplemental calcium you use-it’s very individual, according to other conditions you may have. There are a few better quality organic combos that have been better tested by outside testers.

@kjoed53 Of course we should take the advice of our own MD - AND...if I'm not mistaken, that is basically what the AI article is recommending.
"Large randomized controlled trials—the gold standard in medicine—lack definitive proof that D3 and K2 reduce vascular calcification or heart disease"
Or, am I misreading that statement?

@fred1
To me it sounds like you're discounting anything not supported by large scale studies. If I'm wrong then I misinterpreted your comment. If I'm right then it would be tossing aside many of the options available to us, which is anyone's prerogative. I'm on 3mg LDN which is helping me transition from prednisone to kevzara. It is an off label use that is not supported by large scale studies. LDN is more widely studied and prescribed for fibromyalgia than for PMR, MS, chronic pain or fatigue but even those studies are small in comparison to the studies required for new drugs. Kevzara is approved for PMR but actemra is not, even though both are very similar. Actemra did not have the results from a large scale study to support FDA approval for PMR treatment, but it is sometimes still prescribed and works.