1. < Digestive Health
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Has Anyone Tried the New drug Ibsrela for IBS-C ?

Posted by phxbarb @phxbarb, Dec 19, 2025

I saw that it was approved for adults with IBS - Constipation. I am always looking for new and improved drugs for this condition that I have had all my life. Painful hard rock -like stool with cramps and long-term occurence. So tired of it. Today the usual cocktail of laxatives did not work for me. So miserable and hoping for relief.

Interested in more discussions like this? Go to the Digestive Health Support Group.

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standinginfaith | @standinginfaith | Jul 23 5:51pm
In reply to @zephyr2309 "@standinginfaith I’m reluctant to start another medication. My gastro suggested MiraLax but every day is too..." + (show)
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@standinginfaith
I’m reluctant to start another medication. My gastro suggested MiraLax but every day is too much. Maybe I’ll focus on “microdosing” that instead.

Thanks for responding. Be well.

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@zephyr2309 you're so welcome!! And I don't Miralax every day.. maybe once in a while....continued prayers for you!!

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sara65 | @sara65 | Aug 9 12:07pm
In reply to @phxbarb "I have been on this for 6 days, no BM. How long did you go without..." + (show)
Profile picture for phxbarb @phxbarb

I have been on this for 6 days, no BM. How long did you go without supplimenting with other laxatives, before Ibsrela started working?
So the website says it can take up to 12 weeks to work, but usually starts within the first 2. Has anyone given up on this drug after 2 weeks and what did you do about having a BM while waiting? I thought this would work immediately, especially since they warn about diarrhea. I just have nothing. No cramps, no movement, no feeling about running to the bathroom. Nothing.

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This drug help me out alot.@phxbarb

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sara65 | @sara65 | Aug 9 12:08pm

I just started and it really worked alittle too good

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sara65 | @sara65 | Aug 9 12:09pm
In reply to @jlharsh "Hi @phxbarb, I am hopeful Ibsrela will help your IBS-C. You have to be encouraged to..." + (show)
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Hi @phxbarb, I am hopeful Ibsrela will help your IBS-C. You have to be encouraged to find a new possibility for relief.

I am tagging some that have commented about Ibsrela to find out more about their experiences: @jp9 , @mrsflutterby , @mothermary1 , @standinginfaith , @bunnycuddlez , and @peppatty12

What does your usual cocktail of laxatives consist of?

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Well i did breakfast abd lunch and I should of done lunch and supper cause I hardly gad any breakfast@jlharsh

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sara65 | @sara65 | Aug 9 12:11pm
In reply to @standinginfaith "@zephyr2309 you're so welcome!! And I don't Miralax every day.. maybe once in a while....continued prayers..." + (show)
Profile picture for standinginfaith @standinginfaith

@zephyr2309 you're so welcome!! And I don't Miralax every day.. maybe once in a while....continued prayers for you!!

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Ibdid do Mirlax for awhile but then i ended up not be able to burp. It was horrible@standinginfaith

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sara65 | @sara65 | Aug 9 12:12pm
In reply to @mariannedomino "IBS-C and did Linzess and did nothing.Ibsrela worked good for a week and then nothing.Also MiraLAX..." + (show)
Profile picture for mariannedomino @mariannedomino

IBS-C and did Linzess and did nothing.Ibsrela worked good for a week and then nothing.Also MiraLAX and Metamucil and nothing.
What’s next??

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Lots linzessvus one trulance is another one which I did both. Linzess did work then it stop trulance did not do anything at all@mariannedomino

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tekbek | @tekbek | 6 days ago

I started using Ibsrela about 3 months ago. It does not seem to work at all for me.

Now I am back to Linzess 290 mcg + 1 mg. Prucalopride + 2 (5 mg) tablets of Biscodyle

This weird combination works about 70% of the time, but I have to be near a bathroom about 6-8 hours afterwords.

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bb03 | @bb03 | 5 days ago
In reply to @tekbek "I started using Ibsrela about 3 months ago. It does not seem to work at all..." + (show)
Profile picture for tekbek @tekbek

I started using Ibsrela about 3 months ago. It does not seem to work at all for me.

Now I am back to Linzess 290 mcg + 1 mg. Prucalopride + 2 (5 mg) tablets of Biscodyle

This weird combination works about 70% of the time, but I have to be near a bathroom about 6-8 hours afterwords.

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Look into the vibrant capsule.

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tekbek | @tekbek | 5 days ago
In reply to @bb03 "Look into the vibrant capsule." + (show)
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Look into the vibrant capsule.

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@bb03 what is the vibrant capsule?

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bb03 | @bb03 | 5 days ago

It looks like a white bullet. It’s metal and inside is a battery. You swallow it after it is turned on in a pod. You take it 5 out of 7 days. It turns on when it gets to your large intestine and it starts vibrating which stimulates peristalsis which is the natural muscle lime movement in your intestines. I have greatly decreased peristalsis. Taking this has greatly improved my constipation. I do pay for it out of pocket. It can cost over 200 per month. I pay 189 a month. I’m on Medicare and they do t cover it of course. It contains no medication just a battery hence you can not have an MRI . If MRI needed you need to take lots of laxatives and lots of water to pass the pills, may take a few days and then and the take an x ray to see if no capsules are left in your intestines then you can have your MRI. I wear a medical bracelet that says NO MRI!

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