I started using Ibsrela about 3 months ago. It does not seem to work at all for me.

Now I am back to Linzess 290 mcg + 1 mg. Prucalopride + 2 (5 mg) tablets of Biscodyle

This weird combination works about 70% of the time, but I have to be near a bathroom about 6-8 hours afterwords.