1. < Hypertrophic Cardiomyopathy (HCM)
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Myqorzo: has anyone tried this new alternative to Camzyos?

Posted by jmr091805 @jmr091805, Feb 12 9:58pm

Myqorzo: has anyone tried this new alternative to Camzyos? What do we know about it so far? I have been taking Camzyos since my HOCM became obstructive in January 2025. It's not perfect, but the stories I've heard about the various surgical and chemical-surgical options make me worried about those procedures for me, especially because I have other major health problems.

Interested in more discussions like this? Go to the Hypertrophic Cardiomyopathy (HCM) Support Group.

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priscillaj | @priscillaj | Jun 3 10:44am
In reply to @karukgirl "https://www.myqorzo.com/ https://www.mayoclinic.org/drugs-supplements/aficamten-oral-route/description/drg-80008584 https://www.ajmc.com/view/fda-approves-aficamten-for-obstructive-hypertrophic-cardiomyopathy Hello @jmr091805 , I posted some links for you to read, one is..." + (show)
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https://www.myqorzo.com/
https://www.mayoclinic.org/drugs-supplements/aficamten-oral-route/description/drg-80008584
https://www.ajmc.com/view/fda-approves-aficamten-for-obstructive-hypertrophic-cardiomyopathy
Hello @jmr091805 , I posted some links for you to read, one is from the Mayo Clinic.
Aficamten is the newest drug recently approved for treating symptomatic HOCM.
Comparing Camzyos and Aficamten in my rudimentary search, revealed studies showing similar results with a slight advantage going to Aficamten for exercise capacity.

Deciding which treatment plan you embark on is up to you and your treating physician. Being educated about what you have and what your choices are can take away some of the fear surrounding HOCM.

We all know there is no "cure" for HCM/HOCM, but treatments available can reduce the worrisome symptoms and give us back a little more quality in our lives.

I had open heart surgery, and speaking for myself only...I would do it again if I had to. I was not a candidate for Camzyos as it was not available at the time. I'm so grateful for getting my life back.
We are all different, and none of us responds to medications the same way.
Have you discussed this newer drug with your doctor?

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@karukgirl I would choose open heart septal myectomy if they would let me. I am 72 and physically in shape to do this. It would be like a one and done it seems, for me.

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Linda, Volunteer Mentor | @walkinggirl | Jun 4 4:28pm
In reply to @priscillaj "@karukgirl I would choose open heart septal myectomy if they would let me. I am 72..." + (show)
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@karukgirl I would choose open heart septal myectomy if they would let me. I am 72 and physically in shape to do this. It would be like a one and done it seems, for me.

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@priscillaj I was 3 weeks shy of my 76th birthday in 2022 when I had a septal myectomy at Mayo, age was not a factor. I was fit, never smoked - I was referred to Mayo by my home cardiologist. Please find out your doctor's professional opinion about surgery and it may be a good idea to seek a second opinion. I highly recommend a COE (Center of Excellence) where many are performed each year.

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carolinca | @carolinca | Jun 6 11:01am

I have been taking Aficamten (Myquorzo) 5 mg for three weeks. I have more energy and less shortness of breath. My recent echo showed improvement with my ejection fraction going from 100 to 30! I’ll start taking 10 mg as soon as it arrives. No side effects.

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bitsysmom24 | @bitsysmom24 | Jun 6 12:58pm
In reply to @priscillaj "@karukgirl Once I find out more after my cardiac MRI and have my first good talk..." + (show)
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@karukgirl Once I find out more after my cardiac MRI and have my first good talk about things with my cardiologist I hope I can make a sound decision of how to proceed. I feel like meds are just putting a bandaid on the problem and at best I will be 'hoping' for doing better at bringing groceries in from the car! I have higher goals than that since I have a garden and that takes a little bit of physical effort. Right now my thoughts are to cut right to the chase and ask about the septal myectomy surgery, which might be open heart. If I just bit the bullet (if I qualify) and get it done, then maybe 6-8 months or so, I am hopefully recovered. If there are no complications. I already have a pacemaker from the last cardiology group, who turned out to be somewhat incompetent. I think they just flipped a coin between pacemaker and mitral valve repair. I did specifically express to the dr I had shortness of breath ON exertion. First clue I'd say for this condition we all share. I think I dodged a bullet at that place. The dr came in and said 'we think a pacemaker will benefit you'. WE THINK? I am still new to all this and adjusting to it.

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@priscillaj
I also had an incompetent cardiologist. Last year he offered to set me up with the Camzyos, but never followed through. Then 6 months later after my TTE he told me I needed my mitral valve replaced asap. And my PCP refused to refer me for a second opinion! I fired both and now have an excellent cardiologist and I will shortly be starting on Camzyos. The new cardiologist told me that Camzyos is exactly what I need to try with my condition. If this medication doesn't work, the next step will be the Alcohol Septal Ablation. Best wishes!! Cecile

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linda421 | @linda421 | Jun 9 11:39am

Hi,
I've been on Myquorzo (Afacamtan) 5mg for 2.5 weeks. I also take 5 mg Jardiance and
12.5 Spironolactone and have never felt better. I don't want to jinx things but
I don't have shortness of breath, have increased my daily walks and extend them every day.
I have my followup echo July 18th and hope it shows the good results.
Linda

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