Has anyone ever been on Duloxetine (Cymbalta) for nerve pain?

Posted by dougs72 @dougs72, Jun 22, 2024

Has anyone ever been on Duloxetine (Cymbalta) for nerve pain? I've had 2 doctors push this on me. I know that the side effects can be terrible and getting off of it difficult as it requires titration. One time I remember taking one pill, and not liking the way it made me feel, so not taking any more, and still feeling the "weirdness" from it 2-3 days later. and that was only 30 mg Please pass along any experience or advice from this medication?

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cdammen | @cdammen | 3 days ago

I, too, have reacted negatively or not at all to many meds. Recently I discovered I had 0.0 activity of CYP2D6. In particular codeine has no effect and my body does not tolerate duloxetine and Metroprolol. I expect pharmacogenomics to be the future of medication—where we truly learn why meds work or do not work with the bodies we have.

ams | @ams | 3 days ago

In reply to @ohiogirl48 "I take Duloxetine for my fibromyalgia. The problem is, it's not going to be available much..." + (show)

@ohiogirl48 Why is duloxetine going away?

ohiogirl48 | @ohiogirl48 | 2 days ago

Express Scripts told me a few months ago it would be unavailable until further notice, but from reading all these posts, that isn't the case with everyone. I spoke with a pharmacist at Express Scripts today, and they told me that they haven't had it in stock since February. That seems silly since I've been receiving it since then, and I currently have half of a 90-day supply and a full 90-day supply left. Apparently, the supplier Express Scipts uses can no longer get it from the manufacturer. The pharmacist couldn't tell me why. They also told me I could get 90-day supplies from a retail pharmacy, so the retail pharmacy's supplier isn't having any trouble getting it. So, it looks like this is an Express Scripts issue only. Sorry for the confusion.

susanfrei | @susanfrei | 1 day ago

In reply to @cdammen "I, too, have reacted negatively or not at all to many meds. Recently I discovered I..." + (show)

@cdammen did nothing. I love my gabapentin

jsb932l | @jsb932l | 1 day ago

For me, nothing. Depression and nerve pain, no help. Weaning off now.

cman55 | @cman55 | 5 hours ago

My Girl Friend takes Duloxetine for Depression, and she say's it works for that, but doesn't feel she is getting much help for nerve pain. She was prescribed Journavx, and thought that she was getting help from that. However, it is a new pain reliver that is a non opioid, but can only be prescribed for 10 days. It hasn't been fully studied. Maybe you can ask for it just to see if it will help, but you have to be prepared to be frustrated that you can only have it for a short time if it does help.
She is often in pain, has the SCS, but times of relief are limited to hours, not days.