Anyone taking Mirtazapine? Is it working for you? Any side effects?

Posted by cmarts @cmarts, Mar 4, 2025

Has anyone been taking Mirtazapine? Like to know if they have taken themselves off and how did you do it?

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Profile picture for visionsofelvis @visionsofelvis

@lisalucier hi Lisa just had telemed call with my physician assistant and she advised me to just stop the 7.5 mg of mitrazapine I said and how will I get to sleep and I said I was in stabilizing period which I’m getting lot of anxiety . What would you do? Also I’ve been on 7.5 for 6 weeks

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@visionsofelvis - just wanted to circle back and see what you decided to do. Sounds like you had some doubts about the advice you were given.

Did you do what the physician assistant advised or choose another route?

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Profile picture for Lisa Lucier, Moderator @lisalucier

@visionsofelvis - just wanted to circle back and see what you decided to do. Sounds like you had some doubts about the advice you were given.

Did you do what the physician assistant advised or choose another route?

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@lisalucier physician assistant advised to just stop I said no! I’m seeing a psychiatrist Wednesday hopefully he’ll start me at 3.75 etc

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Profile picture for visionsofelvis @visionsofelvis

@lisalucier physician assistant advised to just stop I said no! I’m seeing a psychiatrist Wednesday hopefully he’ll start me at 3.75 etc

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@visionsofelvis That sounds like a good decision to get some expert advice.

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Profile picture for lynnann50 @lynnann50

Doc prescribed 3.25mg, yes, 1/2 of a 7.5mg teeny tablet.
It makes me so groggy in the morning I’m quitting it.
I take diltiazem 120 extra for heart and so there really is no good sleep aid I can take. (Cardiologist recommended 5mg of trazodone?)
I suffer from “epic dreaming”?? So I never feel rested.
I’m doing my own research, can’t live like this.

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@lynnann50 I feel like you do! I never feel rested and the epic dreaming is ridiculous! I need to get some peaceful sleep.

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Profile picture for bern7475 @bern7475

@lynnann50 I feel like you do! I never feel rested and the epic dreaming is ridiculous! I need to get some peaceful sleep.

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@bern7475 oh gosh! I’m so glad to hear it’s not just me but sorry for you.
What are we doing in Dreamtime??
Trying to fix the world?
Let me know if you find some relief.
I’m a 76yo female and have read that 100mg of progesterone might help. Gotta convince my GP to go for it.

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I have begun to use Magnesium cream/lotion on the soles of my feet at bedtime. It seems to help and I feel relaxed for most of the night. I slept 7 hours last night and was able to go back to sleep!🙌 I’m keeping my fingers crossed that it continues to work.

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Profile picture for ladydi82 @ladydi82

Hello, I’ve been on mirtazapine since March 2025. I was on 15mg, but as of last night I am on 7.5mg. I want to completely taper off. How long should I stay on 7.5mg by experience before stopping completely? Like I mentioned, I haven’t been on it long. Thanks!

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Hello, I was on 45mg Mitrazapine for around 8 months, I went down to 30mg, held for 6 weeks, was fine, then down to 15mg, it’s been 6 weeks and still very anxious and groggy the next day. Could 15mg be causing grogginess and anxiety? My psych said to hold 15mg for 3 weeks then go to zero.

I’m also on 50mg sertraline, I was on 100mg but tapered down to 50mg before I started the mitrazapine taper. I’m also on 6mg of Diazepam, tapered very slowly from 10mg.

I’m curious if the 15mg mitrazapine is causing me to be more anxious than?

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Profile picture for sl2485 @sl2485

Hello, I was on 45mg Mitrazapine for around 8 months, I went down to 30mg, held for 6 weeks, was fine, then down to 15mg, it’s been 6 weeks and still very anxious and groggy the next day. Could 15mg be causing grogginess and anxiety? My psych said to hold 15mg for 3 weeks then go to zero.

I’m also on 50mg sertraline, I was on 100mg but tapered down to 50mg before I started the mitrazapine taper. I’m also on 6mg of Diazepam, tapered very slowly from 10mg.

I’m curious if the 15mg mitrazapine is causing me to be more anxious than?

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@sl2485
I am on 15 mgs. of Mirtazapine and 100 mgs. of Clomipramine for OCD, anxiety and depression. The Mirtazapine was added to help me sleep. The way Mirtazapine works is the higher the dose the more it stimulates Norepinephrine. At 7 mgs. and 15 mgs. it produces more sedation. Sometimes when you are on different medications it’s hard to tell what drug is causing the increase in anxiety. And the change doesn’t happen overnight. Changing medication demands a lot of time and patience. Hang in there and hopefully something clicks .

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Profile picture for mitch4444 @mitch4444

@sl2485
I am on 15 mgs. of Mirtazapine and 100 mgs. of Clomipramine for OCD, anxiety and depression. The Mirtazapine was added to help me sleep. The way Mirtazapine works is the higher the dose the more it stimulates Norepinephrine. At 7 mgs. and 15 mgs. it produces more sedation. Sometimes when you are on different medications it’s hard to tell what drug is causing the increase in anxiety. And the change doesn’t happen overnight. Changing medication demands a lot of time and patience. Hang in there and hopefully something clicks .

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@mitch4444 so essentially at 15mg it’s pretty much just a sleep aid? I was at 30mg until 18th April and doing OK, I then dropped to 15mg and was good at first but last couple of weeks have been hell with anxiety and fatigue. I dropped to 50mg of sertraline back in February so I’m pretty sure it’s not that.

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Profile picture for sl2485 @sl2485

@mitch4444 so essentially at 15mg it’s pretty much just a sleep aid? I was at 30mg until 18th April and doing OK, I then dropped to 15mg and was good at first but last couple of weeks have been hell with anxiety and fatigue. I dropped to 50mg of sertraline back in February so I’m pretty sure it’s not that.

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@sl2485
Yes, it is used for sleep and I’m not sure if it has a small antidepressant effect as well. Your anxiety may be from the change of the medication (s). Sometimes you need to give it more time to settle. Don’t forget all the receptors that are being affected. Mental health medication is never easy. I was on Clomipramine for 30 years and I thought I would try Cipralex. That was a nightmare. The SSRI worked at first then extreme anxiety crept in. I’m back on Clomipramine but is was not easy to get back on after 3 months. Be careful with changes

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