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Tapering off mirtazapine

Depression & Anxiety | Last Active: 2 days ago | Replies (42)

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Hello, I was on 45mg Mitrazapine for around 8 months, I went down to 30mg, held for 6 weeks, was fine, then down to 15mg, it’s been 6 weeks and still very anxious and groggy the next day. Could 15mg be causing grogginess and anxiety? My psych said to hold 15mg for 3 weeks then go to zero.

I’m also on 50mg sertraline, I was on 100mg but tapered down to 50mg before I started the mitrazapine taper. I’m also on 6mg of Diazepam, tapered very slowly from 10mg.

I’m curious if the 15mg mitrazapine is causing me to be more anxious than?

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Replies to "Hello, I was on 45mg Mitrazapine for around 8 months, I went down to 30mg, held..."

@sl2485
I am on 15 mgs. of Mirtazapine and 100 mgs. of Clomipramine for OCD, anxiety and depression. The Mirtazapine was added to help me sleep. The way Mirtazapine works is the higher the dose the more it stimulates Norepinephrine. At 7 mgs. and 15 mgs. it produces more sedation. Sometimes when you are on different medications it’s hard to tell what drug is causing the increase in anxiety. And the change doesn’t happen overnight. Changing medication demands a lot of time and patience. Hang in there and hopefully something clicks .