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Anyone in this clinical trial for low-dose Tamoxifen (LoTam)?

Posted by whitehairwisdom @whitehairwisdom, Jan 13 12:24pm

https://www.clinicaltrials.gov/study/NCT06671912

Is anyone part of this clinical trial which began in Feb 2025? Curious to know if you've had any side effects and what are they?

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carolsue1234 | @carolsue1234 | May 7 6:18pm

I have asked for the CYP2D6 test also. I am just going to keep trying. If I get the denied I will appeal. Usually when I get denied I just give up in frustration. This time I will keep trying!

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jmab | @jmab | May 8 11:30am
In reply to @jardinera25 "@carolsue1234 My oncologist gave me a surprised look when I asked her about "Baby Tam, 5mg"..." + (show)
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@carolsue1234 My oncologist gave me a surprised look when I asked her about "Baby Tam, 5mg" that I'd heard about on the mayoclinic.org support group. She just said that's not approved, it won't work.....later she added they're doing a current trial in the US.
I'm needing to switch oncologists at the Cancer center.....I don't feel I can really discuss things with her that I'm finding out via IA & research articles.

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@jardinera25 My oncologist agreed to prescribe a half-dose (10 mg) of Tamoxifen for me (I'm 72) because he said that the large clinical trials currently being conducted indicate that lower doses of Tam are in the future.

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@mimi09 | @mimi09 | May 9 8:41am

I too would like info on this lower dosage trial. Two years ago at 78 y o, my surgeon recommended a mastectomy and reconstruction. I refused
In 12 days, I’ll turn 80, have a new surgeon, and an appointment with a new med onc.
This is on my agenda for certain!! Same thing happened with fractions of radiation— they’ve been vastly reduced in the standard number prescribed. Some of us remember those days, and some are living with the results of too much radiation. Live & learn…

I wish you the very best and please know you’ll be in my prayers.

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jmab | @jmab | May 9 11:46am
In reply to @mimi09 "I too would like info on this lower dosage trial. Two years ago at 78 y..." + (show)
Profile picture for @mimi09 @mimi09

I too would like info on this lower dosage trial. Two years ago at 78 y o, my surgeon recommended a mastectomy and reconstruction. I refused
In 12 days, I’ll turn 80, have a new surgeon, and an appointment with a new med onc.
This is on my agenda for certain!! Same thing happened with fractions of radiation— they’ve been vastly reduced in the standard number prescribed. Some of us remember those days, and some are living with the results of too much radiation. Live & learn…

I wish you the very best and please know you’ll be in my prayers.

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@mimi09 yes, I am 72 & was diagnosed in August with stage 1 ILC. Had lumpectomy & 5-day radiation & now take half-dose (10 mg) of Tamoxifen. It's all been pretty easy & no real side effects. I agree, treatments are getting better!

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irenegoody52 | @irenegoody52 | May 10 9:29am

On my own I have taken 5 mg of Tamoxifan a day, but stopped because I was having aching in my joints.

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blueroan10 | @blueroan10 | May 11 5:00pm

Due to the success of the trials, my doctor changed my rx from 20mg for 5 years to 10mg for 3 years. I was diagnosed with DCIS at 44 and had lumpectomy and radiation.

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