Anyone taking Mirtazapine? Is it working for you? Any side effects?

Hello, I’ve been on mirtazapine since March 2025. I was on 15mg, but as of last night I am on 7.5mg. I want to completely taper off. How long should I stay on 7.5mg by experience before stopping completely? Like I mentioned, I haven’t been on it long. Thanks!

Ive been on mitrazapine for 4 months 5 days. 3 months on 15 mg and 1 month 5 days on 7.5. Can anyone please tell me if theyve been on it and weaned off? And if they have how did they succeed on getting off it please respond thank you very much

@visionsofelvis - I don't believe I've yet met you on Mayo Clinic Connect, so welcome. I wanted you to know I moved your message here where others were discussing a similar theme about wanting to be off of mitrazapine:

- Tapering off mirtazapine https://connect.mayoclinic.org/discussion/tapering-off-mirtazapine/

Does your prescribing physician have a tapering schedule you might follow to safely taper off this medication with a minimum of side effects? Are you going to be moving to another medication instead of this one?

@drucilla222, congrats on getting off Lorazepam, that’s not an easy thing to do, I see that you’re on the verge of quitting Mirtazapine or otherwise increasing your dose. I was taking Mirtazapine for a short time, about two months, I had a bad experience with this medication, it claimed to help with anxiety and sleep problems but I had the opposite effect, I couldn’t sleep well and when I did, lots of nightmares and anxiety came back, I wanted to stop them after a few weeks but the doctor told me to continue and the symptoms will eventually go away, he was wrong and I wanted to stop them asap, I took 7 mg. daily and then I went on every other day for a week and then every two days until I stopped taking them, happily I had no problems after that, the only thing that Mirtazapine helped me with was my appetite but absolutely nothing else.

@frouke are you still on mitrazapine? Did you wean off it?

@visionsofelvis I did stop talking Mirtazapine quite a while back, I had a bad time with this medication but it was easy to stop, I don’t do very well with most antidepressants so I’m not taking anything else for the time being, I only take Lorazepam.

I have the same symptoms as you have. What dosage are you on? I was on 30mg and have started to reduce it to 22.5mg.

@frouke how long were you on it and at what dose did you stop? Did you wean?

@visionsofelvis I was only on it for a short time, perhaps a couple of months, it started out bad with insomnia and when I did sleep a little I had frightening nightmares, it really amazed me how many people were praising this drug but then we all react differently. I also recall having RLS from it, the only benefit I had was a hearty appetite which I needed, I weaned off of it for a few weeks, I skipped an extra day and it went well with no issues.

@frouke what was your dose? And you didn’t have no rebound anxiety or anything?