@cmarts Good day. I take 45 mg of Mirtazapine at night and usually have a headache the next day around 0500 pm or so which I take 2 extra strength Tylenol to combat this with. It’s not a severe headache, about a five or 6 on the pain meter but it will linger if I do not take the the Tylenol 500 mg X 2. Occasionally I have to take 4 over the course of the day if the headaches start earlier in the day. Just wondering if anyone else has these adverse affects on the drug. Should I decrease the dosage to 30? I’m a little reluctant to do so as I am still having anxiety with 45 and don’t know if lowering the dosage might help or make matters worse.