Wegovy (semaglutide) and Nausea. Any ideas?

Posted by srwolfe @srwolfe, Sep 23, 2024

I have lost 47 lbs since starting wegovy. Started with the lowest dose of 0.25 and have gone up each month. I am now at the highest dose of 2.4 mg. Had a little nausea first week but have tolerated the medication real well. Unfortunately that’s not the case with the 2.4 mg dose. Nausea is real bad for days. The constipation is a big issue for first time since starting wegovy. Any ideas please let me know

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Profile picture for daniellet @daniellet

@roch I have been taking the shot for eight weeks and have yet to lose 1 pound and I am eating mindfully. When I was on Zepbound , pounds were coming off. Any suggestions?

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@daniellet
If the shots are not working, I would recommend contacting your provider to discuss your concerns.

I am tagging @lisalucier if she has suggestions,

Is it Wegovy that you're currently on? Is there a reason you stopped Zepbound?

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Profile picture for daniellet @daniellet

@roch I have been taking the shot for eight weeks and have yet to lose 1 pound and I am eating mindfully. When I was on Zepbound , pounds were coming off. Any suggestions?

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@daniellet - I had similar experiences, but just the opposite. I switched from semaglutide (Wegovy) shots to tirzepatide (Zepbound) shots due to bad GI side effects with the semaglutide.

I lost 53 pounds on the semaglutide, but had only lost 1 pound by the time my insurance coverage cut off right when I got to the top dose of tirzepatide. I then stopped that shot, as my personal costs without insurance coverage would have gotten really unwieldy.

Would the tirzepatide have worked for me if I'd have kept going? Quite possibly. But I don't know.

My husband lost no weight at all on semaglutide till he got to the very top dosage.

So, all I can say from my experience as a non health professional also watching some others we know do these shots is that it's variable by person.

Have you mentioned what you talked about here with your semaglutide weight loss to your provider? If so, what did they say?

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Profile picture for Laurie, Volunteer Mentor @roch

@srwolfe

Impressive weight loss. You're not alone with side effect of nausea, Abby McWaters, Registered Dietitian at Mayo just posted in Weight Management Blog on Mayo Connect with suggestions to prevent or at least reduce nausea.

Managing common side effects from weight-loss drugs:
https://diet.mayoclinic.org/us/blog/2024/managing-common-side-effects-from-weight-loss-drugs
Have you tried any of the suggestions in article?

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@roch This link does not take me to a specific article. Is it an old post perhaps? It goes to the home page of Nutrition and Fitness.

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Profile picture for cindykk2 @cindykk2

@roch This link does not take me to a specific article. Is it an old post perhaps? It goes to the home page of Nutrition and Fitness.

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@cindykk2
Thanks for reporting it. Looks like websites were rearranged. Not sure where the original article ended up, but this newer article addresses the same issues.
https://diet.mayoclinic.org/us/blog/2024/managing-common-side-effects-from-weight-loss-drugs/
I will follow up with the Mayo team on updating the comment.

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I have had the same nausea issues since being on 2.4ml. I was great all the way up to this dose and for the last month had nausea. Reading on Internet it states that this is common for people on this dose with 44% suffering. Unsure whether to reduce back to 1.7ml next week.

I have had constant severe chronic constipation all the way through since start. I increased water comsuption massively, increased fibre, eated bran by the boxful with no joy and tried laxatives, which did nothing (though they only cause the muscles to work on the colon to promote movement supposedly).

The only thing that actually worked for me was Strigol Oral Powders (contains Macrogol) Orange Sugar Free and taste fine. They are different to laxatives as they encourage water to be absorbed into the bowel. The effect after some initial days getting through the backlog (pardon the pun) was wonderful. Had two movements in one day which was unheard of and since then been good, but have to make sure to have one about every other day as I do not want to return to "the old days".

My weight loss if very slow even though I eat very little and wonder if i would still lose the same if I stopped injection and just did Keto diet as I did previously, but think a lot of it is that I cannot exercise due to severe arthritis. Will carry on so far and at least it is coming down. I read of so many people losing massive amounts and sad for me I do not fit that category. Still determined to reduce weight one way or another.

Well done to everyone who has lost weight slow or fast.

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