Problems with Trimix?

Regular needles

Alprostadil, one of the ingredients in Trimix, causes a painful reaction in 20% of men who use it. Increasing the dose only makes it worse. After experiencing the same painful reaction as you have, I am now using a low-alprostadil version of Trimix. The discomfort, though still present, is at a much lower intensity and more tolerable. Another option is Bimix which contains no alprostadil. https://menmd.com/injection-therapy-guide-for-erectile-dysfunction/

I’m trying to determine the correct dose. No swelling or injection issues but rather a dull ache during the erection. Definitely kills sexual interest.

I agree, as much as I want someday to have normal sex , my fear of disappointment makes me only try injections maybe once a week with no satisfaction at all. My prescription was just changed to remove the ingredient that causes the stinging , we will see if it’s any better but if I can’t feel anything or have an orgasm I’m close to sadly give up
. I tried Bimix no stinging but was at 70 units and not a great erection and felt nothing, good luck

Check out this discussion about how to use Trimix
https://connect.mayoclinic.org/discussion/my-trimix-experience/

Thanks, Jeff! I’m doing the suggestions presently, just haven’t found a satisfactory dosing yet.

Although I had good results with Trimix for several years, I was constantly dismayed by the number of times I was left with bruise marks on my penis, even with the auto inject device. For whatever reason, once I started using the VA-prescribed EDEX, I have no more bruising. I don't use the auto-inject anymore, and the fact that it doesn't need to be refrigerated is a big plus. There are two different strengths and it arrives in medicated syringes that one prepares prior to injection. Injecting is still my go-to method of obtaining a good erection.

I had my prostate removed a year ago and I am still dealing with some urinary incontinence and ED.
I am 69 and I have tried with no success to get an erection suitable for intercourse since the operation. Viagra and Cialis do not work. I recently moved up to Trimix Double strength (30-2-20) and have still been unable to get a proper erection. I tried 30 ml, then 60, then 100ml. without success. I am thinking of trying a low daily dose of Cialis to help, and my pharmacy is mixing up Trimix at the (30-2-50) strength and I will try that. If anyone has any insight into this I’d appreciate advice. It’s been very frustrating.

@byng94
This was covered at one of the Mayo Clinic’s monthly meetings. The problem is that in some cases the lining around the penis gets damaged and leaks, as a result It’s impossible to get an erection that will stay for any amount of time..

In that case, the real solution is getting an implant. While, it sounds sort of unconventional they turn out to be very popular, almost 90% of the people that get them really like them.. They can just pump up to a full erection and work just like a normal one. It is covered by insurance to have one put in. Other people in this forum have used them and have been very pleased.

I will include some slides from the talk so you can get an idea what’s going on.

The same company that creates the AUS (Artificial urinary sphincter) That stops Incontinence they have an implant that works very well. Here is a link to the device.
https://www.bostonscientific.com/us/en/healthcare-professionals/products/penile-prosthesis/ams-700-inflatable-penile-prosthesis/fp00000138.html

@byng94 I have similar experiences with Trimix working to a point where it is good for oral sex, but not penetration. My solution has been to inject Trimix, then use a vacuum erection device (ved) after a few minutes. The ved adds a little extra firmness and using a constriction ring prevents blood from leaking out of the penis thus maintaining an erection for up to 30 minutes.