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Elevated Lp(a) levels - does Repatha help?

Posted by klaudiaarnold @klaudiaarnold, Jul 16, 2025

Hi everyone,
After reading up on it myself, I found out there are hardly any medications available to lower highly elevated Lp(a)= levels. However, I came across Repatha and read that it might also help reduce Lp(a) levels. Is there any chance in significantly lowering an elevated Lp(a) level (above 50mg/dl) with Repatha?

• Has anyone had personal experience with Repatha to lower Lp(a)?
• And does anyone know a doctor who prescribes Repatha for lowering Lp(a)?

Thanks in advance for sharing your knowledge or experiences!

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wgr123 | @wgr123 | Mar 9 5:19pm
In reply to @tamig "@tamig My Dr said last week, there was a clinical trial I would have qualified for,..." + (show)
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@tamig
My Dr said last week, there was a clinical trial I would have qualified for, but it closed. He said he would let me know when another opened up.

Do you know how to find when Clinical Trials are open or coming or anything at all regarding them? Haha!

Thank you so much for responding back to me!

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@tamig I don't know anything about the clinical trials work, unfortunately. Dr. Kopecky at Mayo told me about those two promising drugs that they are expecting to be FDA-approved soon. And my cardiologist said the same. But they didn't mention, and I didn't ask, how people get into the trials.

I have a friend who has a form of muscular dystrophy, and a couple of years ago her doctor (I think a neurologist) tried to get her into a clinical trial for an experimental medication. She was going to have to go to Austin, TX, periodically. Ultimately, she couldn't do it. That is my only experience with anyone participating in a trial.

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hsminc | @hsminc | Mar 10 11:20am
In reply to @tamig "@tamig My Dr said last week, there was a clinical trial I would have qualified for,..." + (show)
Profile picture for Tami G @tamig

@tamig
My Dr said last week, there was a clinical trial I would have qualified for, but it closed. He said he would let me know when another opened up.

Do you know how to find when Clinical Trials are open or coming or anything at all regarding them? Haha!

Thank you so much for responding back to me!

Jump to this post

@tamig

Here is a link that may be helpful:
https://clinicaltrials.gov/find-studies/how-to-search

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backhand | @backhand | Mar 11 7:32am
In reply to @wgr123 "@jlharsh @tamig As mentioned above, I went to the Mayo Statin Intolerance Clinic in February. Labs..." + (show)
Profile picture for wgr123 @wgr123

@jlharsh @tamig As mentioned above, I went to the Mayo Statin Intolerance Clinic in February. Labs showed my lipo(a) number was 150, twice the normal number of 75.

I had eight Repatha injections starting last August and eventually (not straight away, about three months into it) had terrible side effects; I had been off it roughly three months when I went to Mayo.

The lipo(a) info was new to me; I don't think I had ever been tested for it before. I don't want to say anything that I might have misunderstood that could be wrong. I went back and read Dr. Kopecky's notes before posting here; we didn't talk about Repatha in relation to lipo(a), only the side effects I had. I had a lipid panel at my physical in September, at which point I'd been on Repatha about seven weeks, and my LDL was down but not by much. Dr. Kopecky did say lipo(a) is genetic and not affected by lifestyle, such as diet and exercise; I thought I understood him to say that there was currently no treatment for elevated lipo(a); I would feel terrible if I'm saying something that's wrong, though.

He said that there are two drugs in clinical trials that are expected to be approved by the FDA to lower lipo(a), possibly as soon as May: Pelacarsen and Opalsiran. He pulled up a spreadsheet on his computer and said he was adding me to his list of people to notify, that I was number 328.

I met with my new cardiologist in the city where I live last week and she said the same thing, that they had actually anticipated that those drugs would have been approved already.

I was...alarmed that my lipo(a) number was so elevated, though heart disease runs on both sides of my family, so I guess it's not surprising.

Wishing the best for you.

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@wgr123 very interesting summary. I went to the Statin Intolerance clinic recently in Rochester and was given a different provider. Although I have an lp(a) more than twice as high as yours no list for the drugs that will be coming of clinical trials was mentioned. I think like everything else, we are our own best advocates. I went there due to intolerance of statins and Repatha. Thanks for reporting back.

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HomeAgainLA | @llynch17056 | Mar 11 9:52am

I was intolerant to statins and then I tried Repatha, which gave me extreme muscle, back and joint pain (and it stayed a LONG time after quitting until I thought it might be permanent). However, I read that Terzepitide had been shown to reduce LPa. I have been on it for 6 months at the lowest dose. I lost about 10 pounds and have maintained that loss, but, the good news is that it DID lower my LPa AND ZERO side effects!!! There are many other clinics that do the same. Some better than others. My LPa has gone from 224.4 (5/9/23) to 120.9 (2/17/26). Still high, but coming down. A lot.

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Mentor
Janell, Volunteer Mentor | @jlharsh | Mar 11 12:51pm
In reply to @llynch17056 "I was intolerant to statins and then I tried Repatha, which gave me extreme muscle, back..." + (show)
Profile picture for HomeAgainLA @llynch17056

I was intolerant to statins and then I tried Repatha, which gave me extreme muscle, back and joint pain (and it stayed a LONG time after quitting until I thought it might be permanent). However, I read that Terzepitide had been shown to reduce LPa. I have been on it for 6 months at the lowest dose. I lost about 10 pounds and have maintained that loss, but, the good news is that it DID lower my LPa AND ZERO side effects!!! There are many other clinics that do the same. Some better than others. My LPa has gone from 224.4 (5/9/23) to 120.9 (2/17/26). Still high, but coming down. A lot.

Jump to this post

@llynch17056 Great LP(a) reduction. Congrats!

Here is some information about Tezepitide:
- Mayo Clinic New Study https://newsnetwork.mayoclinic.org/discussion/new-study-links-combination-of-hormone-therapy-and-tirzepatide-to-greater-weight-loss-after-menopause/
- A Dual-acting GLP-1/GIP Agonist For Blood Sugar. https://www.mayoclinic.org/diseases-conditions/type-2-diabetes/expert-answers/byetta/faq-20057955

Do you know, HomeAgainLA does the product you take have any “stamps of approval”, or safety certifications? Have you had a chance to discuss results with your doctor yet?

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1 reply
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HomeAgainLA | @llynch17056 | Mar 11 1:32pm
In reply to @jlharsh "@llynch17056 Great LP(a) reduction. Congrats! Here is some information about Tezepitide: - Mayo Clinic New Study..." + (show)
Profile picture for Janell, Volunteer Mentor @jlharsh

@llynch17056 Great LP(a) reduction. Congrats!

Here is some information about Tezepitide:
- Mayo Clinic New Study https://newsnetwork.mayoclinic.org/discussion/new-study-links-combination-of-hormone-therapy-and-tirzepatide-to-greater-weight-loss-after-menopause/
- A Dual-acting GLP-1/GIP Agonist For Blood Sugar. https://www.mayoclinic.org/diseases-conditions/type-2-diabetes/expert-answers/byetta/faq-20057955

Do you know, HomeAgainLA does the product you take have any “stamps of approval”, or safety certifications? Have you had a chance to discuss results with your doctor yet?

Jump to this post

@jlharsh I am not diabetic nor even have elevated blood sugar. I’m also not obese. I was about 10 pounds overweight when I started Tirzepitide. So, I was happy about losing the 10 pounds which puts me at the higher end of normal (I was at the lower end of “overweight”). I started the Tirzepitide to see if I could lower my LPa. I am statin and Repatha intolerant. The 10 pound loss and keeping the loss was a side benefit. I never increased my dose from the lowest dose and don’t plan to. It didn’t lower my cholesterol number after 6 months at all, at least not yet.

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19281928 | @19281928 | Mar 13 5:15pm

Repatha lowered my score just a little however, the decided to give me a statin as well and it increased my LP(a) back to where it was , I was very angry at them for giving that drug .

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posty | @posty | 1 day ago

I have a Lipoprotein result of 3,130.8. Is this even possible? Should I start the Repatha injections? I will not take statins. They will only make it worse.

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