I was intolerant to statins and then I tried Repatha, which gave me extreme muscle, back and joint pain (and it stayed a LONG time after quitting until I thought it might be permanent). However, I read that Terzepitide had been shown to reduce LPa. I have been on it for 6 months at the lowest dose. I lost about 10 pounds and have maintained that loss, but, the good news is that it DID lower my LPa AND ZERO side effects!!! There are many other clinics that do the same. Some better than others. My LPa has gone from 224.4 (5/9/23) to 120.9 (2/17/26). Still high, but coming down. A lot.