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Repatha side effects not believed

Posted by dinardoefd @dinardoefd, Jul 26, 2025

Repatha for 16 months and results are amazing however, leg pain, calf pain, started 3-4 ago.
Sore, stiffness in thighs and calves.
I won't mind so much but my doctor insists it is NOT related to medication.
I have statin intolerance, my blood work with geno test shows this.
Why does my doctor not believe me when I say I'm having leg pain suddenly after no other apparent reason?
Am I crazy, am I wrong? 60yr old male with CAD, CAC score over 2k but no blockage all less then 70%, no chest pain.
We believe my 1 of 4 parathyroids, remove in 2001, caused calcium to enter blood was having very high serum calcium levels before being removed. Still have 3 parathyroids with not ill effects but damage has been done.
Can these side effect appear months later as mine have or I can it be something else?

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carolman210 | @carolman210 | Apr 5 12:40pm
In reply to @rnbabs1 "I'm six months in now on 140mg repatha which i take every 3 weeks due to..." + (show)
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I'm six months in now on 140mg repatha which i take every 3 weeks due to my weight being only 95 lb and having side effects from every other med i've tried. I've hit a point where i woke up at 0300 w a horrible headache that under medication is still there after a week. calf pain muscle spasms dizziness abdominal and lower back pain and a restart of some tendinitis. so much for this being the gold standard. my lipid numbers are great but Im a mess!

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@rnbabs1 I used all the mentioned treatments for high cholesterol too and I could not take any of them. I am now taking rosavstatin 2 x per week along with a daily dose of Zetia. My cholesterol is good and no more muscle pain!

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Janell, Volunteer Mentor | @jlharsh | Apr 6 6:35pm
In reply to @rnbabs1 "@jlharsh yes i've tried all the statins (joint pain) nexletol (hip tendonitis) four months to recover...." + (show)
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@jlharsh yes i've tried all the statins (joint pain) nexletol (hip tendonitis) four months to recover. primary has ordered an mri of head just in case and we've stopped the med but im told 4-6 weeks for symptoms to resolve possibly longer. cardio doc said we'll try leqvia when im feeling g better

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@rnbabs1 You have really struggled with trying to find medication to treat your cholesterol. I imagine you were hoping Repatha would be an answer for you after having so many problems with statins and Nexletol.

You mention your doctor ordering an mri as a precaution and that is really good news. Others here have discussed experiences struggling with a burden of needing to find someone to walk through side effects then find effective treatment. It sounds like you have a helpful, attentive doctor.

I now take Leqvio (Inclisiran) and finally have control of my cholesterol. I hope you feel encouraged!

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rnbabs1 | @rnbabs1 | Apr 8 9:32am
In reply to @jlharsh "@rnbabs1 You have really struggled with trying to find medication to treat your cholesterol. I imagine..." + (show)
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@rnbabs1 You have really struggled with trying to find medication to treat your cholesterol. I imagine you were hoping Repatha would be an answer for you after having so many problems with statins and Nexletol.

You mention your doctor ordering an mri as a precaution and that is really good news. Others here have discussed experiences struggling with a burden of needing to find someone to walk through side effects then find effective treatment. It sounds like you have a helpful, attentive doctor.

I now take Leqvio (Inclisiran) and finally have control of my cholesterol. I hope you feel encouraged!

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@jlharsh tx. after side effects wear off i'm willing to try the leqvia. since im an RN im hoping i can self administer info i read said its a good med but doesnt prevent events as well as repatha but if my quality of life is at risk im just going to avoid repatha abs try the leqvia.

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mrsbrown68 | @mrsbrown68 | May 27 3:47pm

I’m so glad to see this comment. I’m on my third injection of Repath and I’m having terrible muscle pain in my legs. I also have dizziness.

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Sue, Volunteer Mentor | @sueinmn | May 27 6:00pm
In reply to @mrsbrown68 "I’m so glad to see this comment. I’m on my third injection of Repath and I’m..." + (show)
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I’m so glad to see this comment. I’m on my third injection of Repath and I’m having terrible muscle pain in my legs. I also have dizziness.

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@mrsbrown68 Are you taking Repatha alone or with a statin? My muscle pain was from the statin, and subsided when I was only on Repatha.

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Janell, Volunteer Mentor | @jlharsh | May 27 6:58pm
In reply to @rnbabs1 "@jlharsh tx. after side effects wear off i'm willing to try the leqvia. since im an..." + (show)
Profile picture for rnbabs1 @rnbabs1

@jlharsh tx. after side effects wear off i'm willing to try the leqvia. since im an RN im hoping i can self administer info i read said its a good med but doesnt prevent events as well as repatha but if my quality of life is at risk im just going to avoid repatha abs try the leqvia.

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@rnbabs1 how are you doing now that more time has passed?

You mention effectiveness of injectables, particularly related to preventing events. This is interesting and valuable to understand. Would you post links to the information you found for Repatha and Leqvio (Inclisiran)?

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seevans | @seevans | May 29 1:27pm

The last statin I tried caused leg cramps and elevated CK. Have not been able to tolerate any statins. Started Repatha end of October 2025 did well until December as cramps started up again and low back ache, doctor reduced to monthly injection from bi-weekly, cramps and low back ache gone but started having hips and legs pain since May 5 and although improved with reduced activity, still not gone. Do have hip arthiritis which may be cause although I've never had this much discomfort before. Not sure if repatha related or not. Have been charting symptoms daily and dates repatha given just to see if correlation or not. Waiting for scheduled appt

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