Leqembi: Anyone else taking this infusion to slow dementia?

@japlok I appreciate this post I just pulled up the alzheimer's article too and it's good to know as a caregiver.

@japlok Thank you for the article. It is very helpful. May I ask how old was your wife when diagnosed? How were her symptoms at that time? Was it very early Alzheimer's? Thanks.

@llthomson My wife was 59 when she was diagnosed with AD. Looking back I can say she probably had it years ago and it has been slow in progressing and her main symptoms at the time were lack of short-term memory, difficulty with finding words for a sentence, difficulty with simple tasks. Those symptoms have not improved with the Leqembi infusions. I still say she is in the early stages of the disease taking over.

At this time my goal is to help guide her in eating healthier, exercise, socialize, challenge the brain, and to overall stay active. That is the only thing I can possibly control in slowing the progression. I will let the Leqembi work on the cleaning of the plaque and tangles.

Ken

My husband was on the leqiembi for several months, but he had a fall which showed a brain bleed, so it was discontinued. After several months, the rain bleed cleared up and he was approved for Kisunla, which is the newdrug. He was on it for Six months, but he experienced some bad symptoms after treatment four and six so we discontinued it. However, he did have a PET scan to determine that his plaque which was quite high when he began was totally gone! I would say it has slowed things down, but dementia is not gone. He still has a lot of trouble with speech and he goes for speech therapy. But I would definitely recommend it.

I'm considering the Leqembi treatment and would like latest patient reviews.

My husband has been on Leqembi since December 2023. He completed the initial 18-month protocol of every two weeks, and then started on the "maintenance" program of every 4 weeks. We're very thankful that he has tolerated the treatment well, even though he has one of the APOE gene combinations that carries a slightly higher risk for brain bleeds. While we can't "prove" empirically that his disease progress has slowed, I am very pleased that we made this choice. Hope that's helpful.

@dlynng Welcome to MayoClinicConnect!I’m so glad you found this discussion group. The members are so helpful and wonderful . And now you can count yourself as one of them.
If I may ask, how did you find MayoClinicConnect?

I came across the group when I was searching for support for people who are taking Leqembi.

@dlynng Thank you for this. My husband is on the 11th infusion, and he carries the APOE gene combo too. But to date, no brain bleeds or swelling I appreciate the feedback. I'll share with my husband.

I may have answered this, but I'll do it again, since this whole thread is about lequembe. My husband was diagnosed with MCI in August, 2025. He went lequembe right away. To date, he's had four MRI's, is going into his 11th infusion next week. No brain bleeding or swelling. He was a little tired at first, but he's tolerated the infusions well. I believe when he gets to the 15th infusion, he has another MRI, then he goes to 18 infusions, MRI and Pet Scans to see the hopeful progress, then on maintenance in June, 2026. We adopted a bit of a better whole foods approach, I'm trying to get him to eat a bit more fruit and a vegetable every night. I read ice cream/sugar wasn't good for MCI, so we don't do as much of that like he used to. He's still forgetful, has trouble solutioning things, but he's still independent, still driving, etc. I've been trying to take over the bills, and that's been a bit of a hurdle, since I'm worried he may click on the wrong thing on his computer, like what happened last year, when we were hacked into. What a mess trying to straighten that out for months.......