Has anyone experienced depression after taking praluent?

Posted by Dkrepid @dlkreps, Mar 27 7:41pm

Has anyone experienced depression after taking praluent? I recently started this PCSK9 after being on rosuvastatin for 3 weeks and experiencing such crippling fatigue and muscle soreness. I’m a very active 62 year old male and am trying to manage my new life after having had a stent placed in LAD.

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@jlharsh

Hi @poppy55 I so, so dislike that your quality of life has dropped this much, I think because I absolutely do feel your pain. Once we quit exercising and not staying strong we begin to weaken. Hang in there! I agree with @dlkreps that it seems like it just shows up one day. The mental part is real.

I have genetically high cholesterol and have been treating since my 20’s. It has never really been under control until the past year or so, and I am grateful to my cardiologist at Mayo Clinic for that. I believe at one point my LDL was almost 300 and now it is 61. It has been an extreme roller coaster, one that I wish I knew then what I know now as to how to attack it. The right docs know how to figure out just what is happening in our bodies and match that to appropriate treatment. I am even currently on the statin I had discontinued when my physical symptoms all began. I am on other drugs for a second time I said I’d never take again. Like any problem, figuring out exactly what you’re trying to treat has the best chance of successfully treating it. The treatment shouldn’t feel worse than what we are trying to treat. Soapbox ended.

Poppy55, do you know what your doc thinks your LDL should be?
Dkrepid, Why did your cardiologist think you should pursue a lipid doc? It sounds like a wonderful idea. When do you see them?

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@jlharsh I’m not sure why the lipid specialist but I presume they might have a better idea on a medication plan. They haven’t called me yet to schedule an appt.

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@dlkreps

@jlharsh I’m not sure why the lipid specialist but I presume they might have a better idea on a medication plan. They haven’t called me yet to schedule an appt.

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It will be interesting to see their perspective of what is going with you. Looking forward to hearing what you learn. Are you feeling any better?

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@jlharsh

It will be interesting to see their perspective of what is going with you. Looking forward to hearing what you learn. Are you feeling any better?

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Thanks @jlharsh I have my good days and bad. I think I’m getting used to the new normal but hope to receive help from the lipid specialist! Thanks again for your insight and sensitivity to everyone on here.

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@kallettla

I was taking stains and ezetimibe. I would take breaks from the statin, then go back on and be symptom free. It ended up that I couldn’t take statins because of my body pain and I haven't figured out if ezetimibe gives me slight leg cramps. I go off and on that one. I did start on Praluent. I didn’t feel well for about 5 days, then it lifted. I had brain fog, diarrhea, and very low energy. I am going to take my second dose today or tomorrow. I am going to try to hydrate a lot before the injection like I did with the COVID vaccine. Then, hope for the best.

I am so sorry people are having such awful symptoms. My Dr said it is usually well tolerated. Is anyone taking it and having NO symptoms?

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I reacted poorly to statins after two years. Statins gave me leg cramps and then a diagnosis of necrotizing myositis. They switched me to praluent and ezetimibe. I’m kind of low energy and lightheaded but on so many meds I doubt it is the praluent exclusively.

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@roslansky

I reacted poorly to statins after two years. Statins gave me leg cramps and then a diagnosis of necrotizing myositis. They switched me to praluent and ezetimibe. I’m kind of low energy and lightheaded but on so many meds I doubt it is the praluent exclusively.

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I am sorry you don't feel well. A friend of mine told me Praluent dropped her LDL 100 points! I hope hpu have such a good outcome.

Last night, I gave myself my second injection and had tingly lips and tongue, so unfortunately, I won't be taking it again.

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@roslansky

I reacted poorly to statins after two years. Statins gave me leg cramps and then a diagnosis of necrotizing myositis. They switched me to praluent and ezetimibe. I’m kind of low energy and lightheaded but on so many meds I doubt it is the praluent exclusively.

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@roslansky I certainly wish you well in your journey! It sounds so cut and dried that if we take these magical medications that we will experience an extended lifespan. Unfortunately many more of us are affected by them than big Pharma wants us to know. It’s much more difficult to zero in on which med is causing the problem when we are taking multiple meds.
@kallettla I was so hopeful with the praluent and then rapatha would work well with my chemistry but no luck. I hope you can find a path and answer to your particular situation.

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Yes, medication has strange side effects sometimes. Praluent, I was told, most people tolerate well. I was very hopeful it was going to be the answer. I see you are in the same boat. My Dad had reactions to medications, too, not that he took many. I have Mast Cell Activation Syndrome usually triggered by artificial fragrance. This was the first medication that I frlg like I was headed toward anaphylaxis. I took 4 Zyrtec, which my allergist told me I could take in an emergency. After 2 hours, the symptoms lessened. I do have an epi pen just in case.

At any rate, I did send off an online report to the FDA explaining my reaction. I hope it helps in some way.

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@roslansky

I reacted poorly to statins after two years. Statins gave me leg cramps and then a diagnosis of necrotizing myositis. They switched me to praluent and ezetimibe. I’m kind of low energy and lightheaded but on so many meds I doubt it is the praluent exclusively.

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What is necrotizing myositis like @roslansky ?

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@kallettla

I am sorry you don't feel well. A friend of mine told me Praluent dropped her LDL 100 points! I hope hpu have such a good outcome.

Last night, I gave myself my second injection and had tingly lips and tongue, so unfortunately, I won't be taking it again.

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Did your mouth weirdness go away yet @kallettla ?

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@jlharsh

Did your mouth weirdness go away yet @kallettla ?

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Yes, thank you for asking. It went away in 2 to three hours. I did not feel well all day, but tonight, I am feeling much better!

I called the pharmacist and he couldn't tell me what would be the most likely allergen...polysorbate, histadine, or the actual medication.

He also told me there is a statin out now that recently became generic. It is very powerful and has fewer side effects: pitavastin. I will first try the generic Crestor once a week and see what happens. He said people don't always take it daily.

Maybe this will help people. I will put it in a post tomorrow.

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