What are the best weight loss medications for seniors?

Posted by sailor1750 @sailor1750, Apr 20, 2025

Information for best weight loss medication for seniors....

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Profile picture for jc76 @jc76

@sailor1750
You don't mention your age. From personal experience as we age our metabolism slows down and the number of calories we used to need to gain or lose weight changes.

I have been an avid exerciser all my life. My weight problem does not come from inactivity. I exercise 6 days a week for 1-2 hours.

What I have found, and this is just what I have found for me, is to concentrate on the types of food you eat. Eating protein really helps fill you up and last a long time. Easily digested food like snacks are quickly absorbed and if you are not exercising will go to fat storage. This comes from a Mayo dietician.

What works for me is what Ginger mentioned mindful eating. Know what you are eating. Why you are eating. And do not eat when distracted, like watching T.V., etc.

You are going to have to find a calorie in and calorie out for you specifically to lose weight. Statistics and weight charts are just statistics and do not address you specifically and your metabolism.

Last year I developed COVID for the first time even though I took all 8 shots. It knocked me down and I could not exercise and ate every comfort food I could find. Then the COVID moved to a sinus infection then to a bronchial infection. I was down for 3 months and then 3 months to get back to my routine. So, I gained 30 lbs. during that period.

Now my body does not to part with all that snacking weight and fights me like Mike Tyson. So back to mindful eating and yes is working but very slowly.
Good luck.

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Mindful eating helped me lose 50 lbs.

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Profile picture for Ginger, Volunteer Mentor @gingerw

@sailor1750 Our bodies are miracle machines, truly. What works for one person may not be as successful for someone else.

The basic premise has been more calories burned [going out] than coming in. Beyond that is knowing what is best for you as an individual. In my situation, being on dialysis everyday for kidney problems, my protein intake is higher than someone else, but it needs to be good quality. My body also enjoys fruit and fresh vegetables. Few carbs. As much fluid intake as allowed for my situation, about 60 oz a day. Water, a cup of coffee, no dark colored sodas, very little fruit juice. My exercise is broken down into chunks of time.
Ginger

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@gingerw
Agree!
Humans are very different it the way medications work, metabolisms, how much they can eat and not gain weight, and so many factors that affect weight.

It does some down to specifically your body in what goes in (food) and what goes out in terms of exercise and movement. But that ratio is different for every single person. So wathing a person eat this or that and thinking you can do the same is not correct.

You really have to find that balance of how much you can eat based on your lifestyle activity that creates a calorie deficit and you lose weight.

I found a simple technique mentioned many times of drinking a cold glass of water prior to eating helps reduce how much you eat due to stomach content of the water. The second one is to eat slowly and I meant chewing and chewing until completely chewed to slow down your eating. Putting down you spoon or fork between bites and eating to last at least 20 minutes to get to that time frame that your brain will say okay not hungry now.

Then on the other side. Find an exercise you like doing (check with doctor first). I love water aerobics as you use weights in the water for resistance and lots of aerobic activity. But that does not mean you will like it. Walking, biking, swimming, walking dog, gardening, hobbies, anything that burns calories and you like doing it.

Everything helps so doing a lot of different things helps for success versus drastic things like just diet or thinking exercise alone will do it.

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Profile picture for jc76 @jc76

@gingerw
Agree!
Humans are very different it the way medications work, metabolisms, how much they can eat and not gain weight, and so many factors that affect weight.

It does some down to specifically your body in what goes in (food) and what goes out in terms of exercise and movement. But that ratio is different for every single person. So wathing a person eat this or that and thinking you can do the same is not correct.

You really have to find that balance of how much you can eat based on your lifestyle activity that creates a calorie deficit and you lose weight.

I found a simple technique mentioned many times of drinking a cold glass of water prior to eating helps reduce how much you eat due to stomach content of the water. The second one is to eat slowly and I meant chewing and chewing until completely chewed to slow down your eating. Putting down you spoon or fork between bites and eating to last at least 20 minutes to get to that time frame that your brain will say okay not hungry now.

Then on the other side. Find an exercise you like doing (check with doctor first). I love water aerobics as you use weights in the water for resistance and lots of aerobic activity. But that does not mean you will like it. Walking, biking, swimming, walking dog, gardening, hobbies, anything that burns calories and you like doing it.

Everything helps so doing a lot of different things helps for success versus drastic things like just diet or thinking exercise alone will do it.

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@jc76 So much of what you said is what I follow. For me, each morning starts with a glass of ice and water. Not only does it refresh and rehydrate me, it gives my system something to focus on while draining dialysis fluids.

Everything is a balancing act, everyday, as we go through life. What was beneficial last year, may no longer be. Be open to making adjustments.
Ginger

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Sometimes some need to be careful with muscle loss using injectable’s.

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Profile picture for projfan @projfan

"Best" depends on what we are looking for, right?

There is a reason that the new GLP-1 RA medications have made such a splash -- they reliably work for most (although not all) people, and do so pretty rapidly. Most other weight loss drugs either work poorly (if at all) or are actively dangerous. If you want to go with other drugs (especially over-the-counter, including herbals and supplements), check out the clinical trials first, and look at any FDA evidence of problems.

I started taking tirzepatide (zepbound) at age 72, and have posted about it before on these blogs. I knew from a lifetime's worth of experience that I would regain the weight I lost plus more doing anything resembling a combination of diet and exercise. Only two solutions have genuinely worked for me in the past, and even they eventually failed: (1) a medically-supervised fast (which really meant living off an extremely low calorie prescription beverage regime), which demonstrated that if I could entirely give up food, I had no difficulties, and (2) bariatric surgery, after which the weight came back very, very slowly.

If I were you, I would do none of those things if this is your first experience with weight loss -- learning new eating habits makes more sense than drugs as a first solution. Plus, learning to eat more healthily and mindfully will stand you in good stead if you do try any of the more serious options. If this is not your first rodeo...

From what I can tell, medically-supervised fasts are no longer available.

Bariatric surgery is a great alternative at pretty much any age, if you qualify and are ready for it. It was coupled with the best behavioral re-training experience I've ever had, which has helped me greatly in my latest use of the GLP-1 RAs. Some people do experience side effects, as I did, but any solution that reliably works risks those. The big advantage of surgery over the GLP-1s (or any drug) is that it's one-and-done. You really, really want to take the prep and follow-up seriously -- I've got a friend who essentially lied her way through the process, and it didn't end well.

Most recently, I lost all the weight I had regained since the surgery, using first tirzepatide (zepbound) and now semaglutide (ozempic). I've had a variety of side effects (as with the surgery, most people do not experience side effects, but some, like me, definitely do), and that was the primary reason that led me to switch drugs within the GLP-1 RA family. The big advantage of these drugs is that in most cases, the side effects go away if and when you stop the drugs -- you can't stop surgery (although the surgeries can be reversed if necessary). The big disadvantage is that no one has figured out a great way to get off of them -- usually, if you don't stick with the drugs, the weight comes right back. (And unlike the surgery, there's no systematic prep and follow-up, which means they just give you the drug with no wrap-around services to address our underlying issues.) Therefore, you may be on the drugs for life.

But age is not a problem with any of these.

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@projfan Can these weight loss drugs be taken at any age as I’m a female age 83? Just need to lose 10/15lbs. I’m in reasonably good health.

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Profile picture for surechamp @surechamp

@projfan Can these weight loss drugs be taken at any age as I’m a female age 83? Just need to lose 10/15lbs. I’m in reasonably good health.

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@surechamp Yes, they can. I'm currently 74, and expect to be on it for the rest of my life. Medicare won't cover for weight loss, though, so you'll have to private pay, unless you've got some other issue for which Medicare will cover the drug -- typically diabetes or sleep apnea.

The advantage of paying yourself is that you have full control over which drugs you take, at what dosages, and for how long. My GP is fine leaving those choices in my hands, probably because we've built mutual trust and I am prepared to explain my rationale in detail. This means you can also experiment and learn from your personal experience, which is good.

Although GLP-1 receptor agonists don't have a lot of drug interactions, they do have some -- you can ask your GP or pharmacist whether anything you are taking now would be an issue. And if you have issues with your pancreas, you should be cautious.

There are more options now than there were when I started, including, I believe, at least one version in pill form. (I prefer to minimize the drugs that pass through my gastro system and have no problem with needles, so I'm sticking with an injectable.) For this level of weight loss, you might also consider some of the older, pre-ozempic formulations, which may be less expensive.

I would personally avoid the compounded drugs or anything from a source that isn't fully quality checked, or that might have gotten warm during the shipment and storage process. It's really important that these liquid forms (injectables) be kept refrigerated from manufacture through use. This is why I personally buy through my usual pharmacy and purchase branded, FDA-approved products. But there are people who don't, and do fine, or so I hear.

If you only want to lose 10-15 lbs, you might want to consider just sticking with the starting dose to see if that will work on its own, and if not, ramp up really slowly, and ramp back down to the starting dose once you hit your preferred weight. You will probably never come close to the max dosage. This can also be less expensive, especially if you are willing to purchase zepbound (tirzepatide) in vials rather than an injectable pen. If you go with the vials, you need more skill for self-injection than with the pens -- may want a nurse to coach you through it.

Side effects are not uncommon, but for most people they go away or become tolerable when you reduce dosage or stop the drug, so you can just give it a try to see what happens. If you select a product that comes in a multipen, you can take partial doses -- I do that all the time. This lets you ramp up and down more gradually and even stabilize at exactly the dose that works for you in the end. (The manufacturers have kittens when they hear about this because they say that the multipen does not reliably measure those in-between doses. However, the limited research I've seem on the subject says that it does. Nonetheless, this is something to try at your own risk.)

I'm currently using an ozempic multi-pen at a low enough dose that the 30-day pen lasts for 60+days.

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Thanks so much for your detailed information. I don’t have a problem with needles but thinking pill form maybe easier for me. Your primary doctor didn’t have any hesitation in prescribing this drug for you? I’m type 2 diabetic & was on rebelsous but became in control my last blood work so doctor took me off it plus insurance wouldn’t pay if in control but kept my weight in check when I was taking that drug. Thanks so much again for your information & reply.

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Profile picture for surechamp @surechamp

Thanks so much for your detailed information. I don’t have a problem with needles but thinking pill form maybe easier for me. Your primary doctor didn’t have any hesitation in prescribing this drug for you? I’m type 2 diabetic & was on rebelsous but became in control my last blood work so doctor took me off it plus insurance wouldn’t pay if in control but kept my weight in check when I was taking that drug. Thanks so much again for your information & reply.

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@surechamp
I am on the foundayo pill. Unlike some of the other options that require being taken on an empty stomach before anything else, foundayo can be taken any time of day.

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I haven’t heard of that pill, but I thank you for the information you gave. Sounds good that you can take it on either a empty stomach or a full stomach.

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