Anyone else out there with extremely high lipoprotein (a)?

I added Rapatha and my LPa went down to 435 and LDL 65 HDL85. I am going to switch to crestor from Lipitor. Rapatha brings LPa down a little not much.

Rapatha brought my LPa down a little. same here my family lives to be in their 90's my mother is 87 LPa 455. No stroke No heath problems. I think the stress is the worst part.

I'm in the same boat. Mine is 438. I thought I was doing ok until I had my last Echo and ECG. Not only showed narrowed arteries and calcification, but I had a surprise silent heart attack. I've done a lot of research since I found out I have high Lpa. My primary had no clue what to do a bout it, or if it even needed to be treated. I haven't been able to find much about what to do about it. The consensus it is bad and it raises our chances of heart attacks and complications a lot. Unfortunately I have no clue of how to get treated or with what. I am looking into joining some studies. I know I didn't help much, but at least you know you're not alone.

Shortly after discovering I had blockages that were ultimately corrected via 3 stents (July of 2022), it was determined that I had elevated LP(a) levels (221). As others have noted, statins and lifestyle changes won't lower LP(a) levels. I found one study that suggested whey protein (approx 60 gms (2 scoops)) was effective in lowering LDL.
In Sept of 2023, I started taking whey protein.
In July of 2024, I applied for a clinical study of Lepodisiran (phase one trial had shown a 90% reduction).
Much to my surprise, my LP(a) had dropped to 117 (still too high, but a nice improvement).
I stopped the whey protein in thehopes of being retested and accepted into the trial.
One month later, my LP(a) was back up to 160, not quite high enough to be accpeted into the study.
I resumed my daily whey protein intake, and in Dec 2024, it was down to 88.

Lysine, an amino acid, has shown potential in reducing Lp(a) levels when combined with vitamin C. A study in postmenopausal women found a significant decrease in Lp(a) levels after 6 months of taking 3 grams of ascorbic acid and L-lysine monohydrochloride daily, with a 48% reduction in one individual. This regimen is based on the theory that lysine can inhibit Lp(a) binding, while ascorbic acid aids in collagen repair and acts as an antioxidant.
Elaboration:

Lysine's Role:
Lysine is an essential amino acid that plays a role in protein synthesis. In the context of Lp(a), it's believed that it can interfere with the binding of Lp(a) to other molecules, potentially reducing its ability to contribute to plaque formation.

Vitamin C's Role:
Ascorbic acid (vitamin C) is a potent antioxidant that can help repair collagen damage in blood vessels, potentially reducing the overall impact of Lp(a) on the cardiovascular system.
Combined Approach:
The combination of lysine and vitamin C has shown promising results in reducing Lp(a) levels, particularly in individuals with elevated levels and a family history of heart disease.

What brand of whey protein did you use?

The LPA medication is still in the research pipeline. They don't know if it will decrease the number of cardiac events or deaths yet. (from my Mayo cardiologist in March 2025)

There is no approved treatment for high Lp(a), but five drugs are in development, and last fall, two of them – Muvalaplin and Zerlasiran – moved a step closer to consideration by the FDA. Muvalaplin performed so well in a phase II trial (lowering levels by 86%) that its lead researcher expressed surprise. Jan 21, 2025.
In the meantime, an Epidemiological study determined that Vitamin C and Lysine kept LP (a) from making LDL more sticky. My LP a was not overly out of range, but after 5 years on the above 2 supplements it has greatly improved.

did you use whey protein as the source of lysine or did you take a tablets or capsules? Also have you had a calcium score and if so how was it?

Thank for your question and thanks for your awareness of supplements for this important issue.

The quick answer to your question is that I mostly get Lysine from 3 sources and I alternate between them. Most days I eat canned sardines or tuna "in water", not oil, as studies show water is a healthier choice. Tuna in water has about the same profile as sardines which equates to approximately 2-2,500 mgs per 3 oz can. Sometimes I eat a can of each at the same time with two boiled eggs and some mayonnaise. That would put a value close to 5,000 mgs on those days. Other days I use a scoop of vanilla flavored whey protein mixed with powdered milk and I eliminate one or the other of tuna/sardines. A scoop of whey protein equates to approximately +/- 2,300 mgs.

But Lysine is NOT the total answer. So what does Lysine do? Ask any Pharmacist (doctors may not know) Lysine is a wound healer. It's best known for cold sores around the mouth. taking lysine on a regular basis helps prevent outbreaks of cold sores and genital herpes.

Lipoprotein (a) is also a wound healer that operates in the endothelium (inside the cellular structure of the coronary arteries) of the heart. It's a natural response to the plaque build up in there. It's duty is to "patch up" the inside of the artery wall due to a Vitamin C deficiency. Vitamin C enchances this process. A minimal of 750 mgs of Vitamin C daily has been demonstrated for the process to work along with Lysine. I personally take upwards of 2,000 mgs per day...not all at once. (500 mgs 4 times through out the day). If a person is sensitive to ascorbic acid, (stomach issues), there are other forms, like "neutral" C.

Lp(a) is similar to LDL cholesterol, but it is even more “sticky” than typical LDL cholesterol, making it even better at sticking to artery walls and potentially causing harmful blockages.

If you go to your favorite search engine and type in ("name the lipoproteins"), the first paragraph below is basically what you will find.

"The main classes of lipoproteins, which are classified based on density, are chylomicrons, very low-density lipoproteins (VLDL), intermediate-density Lipoproteins (IDL), low-density Lipoproteins (LDL), and high-density Lipoproteins (HDL)."

Why is lipoprotein (a) never listed...as if it doesn't exist?

If cholesterol is the problem, why don't we see venouscelrosis? Plaque build up in your ear lobe, toes, nose etc? The same blood travels everywhere in the body.

Please study the Gulo gene.

The GULO gene encodes the enzyme L-gulonolactone oxidase, which is crucial for vitamin C biosynthesis in many animals, but is non-functional in humans and other primates due to mutations, resulting in the inability to synthesize vitamin C.

One more thing. MAGNESIUM. Studies show that the majority of people in the United States are deficient in Magnesium. In most of our trials, Magnesium in most cases will help (or sometime eliminate) irregular heartbeat beat. Please study.

Final thoughts. Doctors say (especially Cardiologist) say supplements create expensive urine. You get all the nutrients in your diet. Please let me know if you find all the vitamins and minerals in the foods most people eat today and I'll change my mind. Farmers only put N-P-K fertilizer in the soil. What about the other 60+ minerals that need to be there? The price to add these would cause a farmer to go broke. Plants need all minerals to give humans the daily nutrients. They can't if the minerals are not in the soil. If you know of a commercial farm that provides all nutrients back to the soil, please let me know.

Cardiologist and doctors die from cardiovascular disease just like the rest of us.

Why don't animals have heart attacks and strokes? Look it up.