ARINA-1 Clinical Trial with nebulized solution-NO ANTIBIOTICS

Posted by becleartoday @becleartoday, Aug 17, 2023

GOOD NEWS!!!

We have been asking for bronchiectasis treatments that are not antibiotics, and we have been heard!

Dr. Charles Daley is a well-respected expert from National Jewish Health in Denver. He was a keynote speaker at the World Bronchiectasis Conference and gave the closing remarks.

Dr. Daley is also the principal investigator of a study evaluating ARINA-1, a nebulized solution manufactured by Renovion that has been shown to prevent mucus from clogging our airways. Clogged airways cause inflammation and infection, a cycle we try to break with daily airway clearance and, often, antibiotics.

ARINA-1 is a sterile formulation that is manufactured under strict guidelines. The solution includes glutathione, ascorbic acid, and a buffer to modify the pH.

The trial will measure ARINA-1’s impact on quality of life, mucus viscosity, and inflammation.

Researchers are looking for 25 more participants for the 28-day study. Participants need to be diagnosed with non-CF bronchiectasis and have mucus. In addition to National Jewish in Denver, trial sites are located in Baltimore; Philadelphia; Seattle; Birmingham, AL; New Orleans; Tyler, TX; Winston-Salem, NC; Portland, OR; and Charleston, SC. If you live in or around one of these areas and are interested in the trial, let me know.

Click on the following link to clinicaltrials.gov for more information on the ARINA-1 trial.

https://tinyurl.com/tsh6fjnr

I am working with Renovion and researchers to share this opportunity, and I can help answer basic questions regarding:

-Participating doctors
-Laboratory studies of ARINA-1
-How nebulizing this solution differs from nebulizing glutathione alone or orally administered NAC
-The importance of the combination of glutathione and ascorbic acid

If you have other questions about the trial, the drug or how to enroll, let me know and I can help you get an answer from the Chief Scientific Officer at Renovion who is a great resource.

Most importantly, discuss this trial with your doctor.

Dr. Daley implored us to get involved in bronchiectasis and NTM research. Let’s show him and the researchers working on our behalf that we are willing to participate whenever possible.

Interested in more discussions like this? Go to the MAC & Bronchiectasis Support Group.

bradzepfan | @bradzepfan | Sep 17, 2023

I am interested and can make it to the NC or AL region.

becleartoday | @becleartoday | Sep 17, 2023

Fantastic! Email Carolyn at Carolyn @renovion.com. She can help you make arrangements and there are travel stipends at some of the test sites.
Let us know how it goes,
Linda Esposito

aerogirl | @aerogirl | May 9 12:21pm

I'm "late to the party" on your post, but am certainly interested! Guessing they no longer need participants, but if you know of another study opportunity, please share. I'll check out your tiny url to see if I can get an update on this trial. This is very hopeful! Thanks, Shelly

lilianna | @lilianna | May 10 6:37am

Ichgcp.net I found this from April 1 2024 about Arina1 phase 2a study. They were looking for participants in the study.

becleartoday | @becleartoday | May 10 7:03am

Phase 2 is complete. I will let everyone know when phase 3 begins.

narelled23 | @narelled23 | May 10 9:23am

In reply to @becleartoday "Phase 2 is complete. I will let everyone know when phase 3 begins." + (show)

Do you know if anything happening in Australia?

becleartoday | @becleartoday | May 10 9:27am

No, not yet. But I understand how excited you are to be involved!

busybeans | @busybeans | May 10 1:58pm

This is such exciting news! I've been a patient of Dr Daley's at NJH since 2011 - and never been able to tolerate the Big 3. This could literally be life-changing. Thank you for this information and please let us know if/how/when more patients are needed for trials. My hand is waving in the air like a third-grader's!